Objective To investigate the effect of cyclosporine blood level at first year after kidney transplantation on patients with a survival time over 10 years. Methods 380 patients with functional allograft, a survival time over 10 years and long-term administration of cyclosporine A (CsA) were studied, and received CsA-based treatments. According to the blood CsA level at the first year after kidney transplantation, patients were divided into five groups: group 1, blood CsA level was above 0. 208 μmol/L (1 μmol/L = 1201.9 μg/L), group 2, blood CsA level between 0. 166-0. 208μmol/L; group 3, blood CsA blood level between 0. 125-0. 166 μmol/L; group 4, blood CsA blood level between 0. 083-0. 125 μmol/L; group 5, blood CsA level less than 0. 083 μmol/L. Systolic blood pressure (SBP), diastolic blood pressure (DBP), serum creatinine(SCr), uric acid (UA), cholesterol (CH), triglyceride (TG), alanine aminotransferase (ALT), direct bilirubin (DBil) and total bilibubin (TBil), albumin (Alb), hemoglobin (Hb), count of white blood cells and positive rate of proteinuria in 5 groups at the 1st, 5th and 10th year after kidney transplantation were analyzed. Results At the 5th year SBP in groups 1 and 2 was higher than in groups 3, 4 and 5. UA level in group 5 was lower than other groups, and Alb level in group 5 was higher than other 4 groups. Proteinuria positive rate in groups 4 and group was lower than other groups. At the 10th year after kidney transplantation,indexes among 5 groups had no statistically significant difference, except for SBP, DBP, DBil and CH in some groups. There was also no significant difference in SCr level among 5 groups at the 5th or 10th year after transplantation. Conclusion Blood CsA levels at the first year after kidney transplantation has no significant effect on long-term allograft function. But higher level of CsA (＞0. 166μmol/L) at the first year maybe predict high rate of hypertension, high blood UA and proteinuria at the 5th and 10th year after transplantation.

Objective To compare the glomerular filtration rate (GFR) measured by Gates method based on renal dynamic imaging before and after ultrasonic depth correction in patients with different degrees of hydronephrosis.Methods Renal dynamic images of 113 patients (65 males,48 females;average age:(45.7± 10.3) years) with hydronephrosis from October 2015 to October 2016 were retrospectively analyzed.The GFR was also determined with cystatinC (CysC) method within 1 week.According to the degree of hydronephrosis,patients were divided into mild,moderate,severe hydronephrosis groups.The GFR (total GFR,GFR of the impaired kidney,GFR of the normal kidney) was determined by Gates method,and was measured again after the kidney depth being corrected by ultrasound.One-way analysis of variance analysis,the least significant difference t test,and paired t test were used.Results In severe hydronephrosis group (n=55),GFRs (ml · min-1 · 1.73 m-2) of the impaired kidney before and after the depth correction were significant different (14.9±6.2 vs 9.6±5.8;t=4.63,P＜0.05),and total GFR (ml · main-1 · 1.73 m-2) before depth correction and GFR (ml · min-1 · 1.73 m-2) determined by CysC method were also significantly different (32.1 ± 12.2 vs 26.2±10.2;F=1.58,t=2.75,P＜0.05).There was no significant difference between GFR before and after depth correction,between total GFR and GFR measured by CysC method in mild (n =43) and moderate hydronephrosis groups (n =15),and between total GFR after being corrected and GFR measured by CysC method in severe group (F values:1.72-2.39,t values:0.31-0.91,all P＞0.05).Conclusion Ultrasonic depth correction may have greater clinical significance in GFR measurement by renal dynamic imaging for patients with severe hydronephrosis.

The incidence of colorectal polyp shows an upward trend, and some types of colorectal polyps, may evolve into colorectal cancer. Dyslipidemia is not only related to the occurrence of cardiovascular diseases, but also related to the occurrence and development of colorectal polyps. Hyperlipidemia can directly or indirectly stimulate the proliferation of colorectal mucosal cells and lead to tumorigenesis. Exploring the factors affecting the occurrence and recurrence of colorectal polyps may be conducive to prevent and manage the disease. General practitioners should pay attention to the high-risk group of colorectal polyps, and timely health education and colonoscopy screening are important measures to prevent its occurrence and further cancer development.

【Objective】 To explore the causes of hypothermia in patients undergoing transurethral thulium laser prostatectomy. 【Methods】 A total of 170 patients who underwent transurethral thulium laser prostatectomy in our hospital during Sep.2020 and May 2021 were prospectively enrolled in the study. The patients were divided into normal body temperature group (n=143) and hypothermia group (n=27), based on whether perioperative hypothermia happened. The clinical data were analyzed to evaluate the risk factors of hypothermia. 【Results】 Univariate analysis showed that there were statistical differences in anesthesia time, operation time, prostate size and total amount of perfusion fluid between the two groups (P<0.05). Logistic analysis showed that the size of prostate was the independent risk factor of perioperative hypothermia (P<0.05). Patients were further divided according to prostate size. For patients with prostate < 80 g, the size of prostate was the independent risk factor of perioperative hypothermia (P<0.05), while for patients with prostate ≥ 80 g, the amount of perfusion fluid was the independent risk factor (P<0.05). 【Conclusion】 Perioperative hypothermia in patients undergoing transurethral thulium laser prostatectomy is related to the anesthesia time, operation time, prostate size and total amount of perfusion fluid. It is necessary to evaluate the risk factors before operation and take effective thermal insulation measures.