Objective To investigate the influencing factors of early compensation pathway formation in patients with cerebral infarction of internal carotid artery system. Methods Eighty-eight consecutive patients with cerebral infarction in the internal carotid artery system admitted to the Department of Neurology,the First People's Hospital of Bijie, Guizhou Province from February 2016 to March 2018 were enrolled retrospectively. They were divided into low-open group (n =26) and high-open group (n= 62) according to the degree of collateral circulation opening. Hie differences of sex,age,smoking history,drinking history,hypertension, diabetes,hyperlipidemia,family history of cerebral infarction,degree of internal carotid artery stenosis, volume of cerebral infarction, Nalional Institutes of Health Stroke Scale (NIHSS) score in patients of the two groups were compared. Multivariate logistic regression analysis was used to screen the influencing factors of highly open collateral circulation. Outpatient follow-up was performed in the two groups of patients at 3 months after discharge. Their activities of daily living (ADL) scale scores were compared. Results (1) The proportion of hypertension, diabetes mellitus, and hyperlipidemia in the patients of the collateral circulation low-open group was higher than that in those of the collateral circulation high-open group,and the differences between groups were statistically significant (80.8% [21/26]vs. 58. 1% [36/ 62],57. 7% [15/26] vs. 14. 5% [9/62],96. 2% [25/26] vs. 53.2% [ 33/62 ], all P < 0. 05). There was no significant difference in the proportion of male,age ≥60,family history of cerebral infarction,smoking history,and drinking history between the groups (all P>0.05). (2) The NIHSS score and infarct volume of the collateral circulation low-open group were higher than those of the high-open group,and the proportion of severe stenosis of internal carotid artery was lower than that of the high-open group ([18 ±5] to. [10 ±3] ,89 [46, 145] mm3 vs. 35 [ 12,70] mm3,42. 3% (11/26) vs. 66. 1% (41/62) ;all P <0. 05 |. There was no significant difference in the time from onset to CTA (P > 0. 05). (3) With the collateral circulation high-open degree as the dependent variable,after variable screening,multivariate logistic regression analysis of hypertension .diabetes, and severe stenosis of internal carotid artery was performed. The results showed that diabetes was a risk factor for the collateral circulation high-open degree (OR, I. 361 ,95% CI 1. 277 - 2. 475 ,P = 0. 032) ,and severe internal carotid artery stenosis was a protective factor of collateral circulation low-open degree (OR, 0. 614,95% CI 0. 513 -0. 724, P - 0. 027). Hypertension was not associated with the degree of collateral circulation opening (P < 0.05). (4) The ADL scale score of the collateral circulation low-open group was lower than that of the high-open group, and the difference between the groups was statistically significant ( [ 51 ± 15 ] vs. [ 67 ± 18 ] , t = 3. 746, P < 0. 01 ) . Conclusion Cerebral infarction of internal carotid artery system patients with diabetes was not conducive to the establishment of early good collateral circulation, and with severe carotid stenosis was conducive to the establishment of good collateral circulation.

Objective To observe the effects of fennel essential oil and water extracts (distilled oil is not included) on gastrointestinal motility disorder caused by atropine in mice.Methods Kunming mice were randomly divided into blank control group, model group atropine, water extracts group, fennel essential oil group, mosapride group. Blank control group and model group atropine were orally administered with normal saline of 0.2 ml/10 g. Water extracts group was orally administered with Water extracts (75 mg/ml) of 0.2 ml/10 g. Fennel essential oil group was orally administered with Essential oil of 300 mg/kg. Mosapride group was orally administered with mosapride(15 mg/ml). Subjects were orally treated for 3 d. After fasting for 18 h, blank control group was intraperitoneally injected saline on the fourth day, and other groups were injected atropine sulfate injection to induce animal model of gastrointestinal motility disorder. Blue dextran(BD)2000 was used to observe the gastric emptying rate and rate of intestinal propulsion. Results Gastric emptying rates of fennel essential oil group, mosapride group, water extracts group and model group atropine were respectively(91.97±4.42)%, (90.26±5.81)%, (80.01±6.27)%,(72.88±9.13)%,and intestinal pushing rates were respectively(53.32±7.49)%,(53.02±9.13)%,(44.16±7.68)%,(37.52±6.19)%.Fennel essential oil, mosapride and water extracts enhanced the gastric emptying and intestinal propulsion in gastrointestinal motility disorder animal caused by atropine(P values were 0.004、0.001、0.004、0.003、0.025、0.015),where Fennel essential oil and mosapride were superior to the water,extracts(P values were 0.000、0.002、0.001、0.001).Conclusion Fennel extracts may promote gastrointestinal movement of atropine-induced gastrointestinal motility disorder in mice and fennel essential oil is the main active ingredient.

Objective To analyze the joint efficacy of butylphthalide(NBP)and limb ischemic postcondi-tioning(LIPost C)in the treatment of elderly patients with atherosclerotic cerebral infarction.Methods A total of 160 patients with large atherosclerotic cerebral infarction hospitalized in Bijie Hospital from October 2020 to October 2022 were divided into four groups:NBP,LIPost C,NBP + sham LIPost C,and NBP + LIPost C by the random number table method,with 40 cases in each group.Before and after one-month treatment,the four groups were compared in terms of collateral circulation evaluated by the leptomeningeal scoring(rLMC),neurological function evaluated by the National Institutes of Health Stroke Scale(NIHSS),limb function disability evaluated by the Modified Rankin Scale(MRS),cognitive function evaluated by the Mini Mental State Scale(MMSE),daily living ability evaluated by the Barthel Index,as well as the occurrence of bleeding adverse events.Results After one-month treatment,the four groups all showed an increase in the rLMC score,with the NBP + LIPost C group significantly higher than the other three groups(P＜0.05),and a decrease in the scores of NIHSS and MRS at each time point,with the NBP + LIPost C group significantly lower than the other three groups(P＜0.05).Additionally,the four groups demonstrated an increase in the MMSE score and Barthel index at each time point(P＜0.05),with the NBP + LIPost C group higher than the other three groups(P＜0.05).Moreover,all the four groups showed no statistically significant difference in the incidence of bleeding adverse events(P＞0.05).Conclusion NBP com-bined with LIPost C can effectively promote the establishment of collateral circulation and the recovery of neurological function in elderly patients with atherosclerotic cerebral infarction.Meanwhile,it can improve their motor function,daily living ability,and cognitive function.Moreover,it has high safety.