1.Dual Coding Genes in Eukaryote
Zhiyong SHEN ; Zhifeng LI ; Xingyi HANG ; Chenggang ZHANG
Progress in Biochemistry and Biophysics 2006;0(05):-
Dual coding is a phenomenon which refers to a mature mRNA that contains two open reading frames(ORFs) in the same direction to code two different proteins.This phenomenon is quite common in prokaryote,bacteriophages and viruses as an economical and effective way to present the genome information.However,recent reports suggest that the dual coding phenomenon does also occur in eukaryote.Dual coding will help us to further understand the complicated regulation of eukaryotic genes or even the law of molecular evolution.
2. Research Progress on Relationship Between Small Intestinal Bacterial Overgrowth and Nonalcoholic Fatty Liver Disease
Xingyi SHEN ; Xiaofeng YU ; Yili TONG ; Jiaxi ZHAO
Chinese Journal of Gastroenterology 2020;25(12):745-748
Nonalcoholic fatty liver disease (NAFLD) is a clinical syndrome characterized by hepatic steatosis and fat deposition in hepatocytes in the absence of significant alcohol use. A growing number of studies have shown significant dysregulation of intestinal microbiota in patients with chronic liver disease and cirrhosis. Small intestinal bacterial overgrowth (SIBO) is a clinical syndrome induced by excessive bacteria in small intestine. This article reviewed the correlation between SIBO and NAFLD, as well as the effect of probiotics on treatment of NAFLD.