Objective　To explore the correlation between the expression of TPO-Ab and FT3 and prognosis in patients with acute cerebral infarction and its mechanism.Methods　Research object selection in our hospital between January 2018 and January 2021,120 cases of acute cerebral infarction patients,all patients were divided into good prognosis group (60 cases) and poor prognosis group (60 cases),TPO-Ab,FT3 expression were observed and compared between the two groups of patients with platelet function,inflammation,related parameters of hemodynamics,blood vessel function.Results　The levels of TPO-Ab,CD62p,CD63,platelet aggregation rate,plasma viscosity,whole blood viscosity,hematocrit,serum inflammatory factors and ET-1 in the good prognosis group were lower than those in the poor prognosis group,and the levels of FT3 and NO were higher than those in the poor prognosis group (P<0.05).Abnormal levels of TPO-Ab and FT3 were independent risk factors for intracranial artery stenosis,and their levels were correlated with platelet function,inflammatory response,hemodynamics and vascular function (P<0.05).Conclusion　The prognosis of patients with acute cerebral infarction is correlated with the expression of TPO-Ab and FT3.The expression of TPO-Ab and FT3 can affect the prognosis of patients by affecting platelet function,inflammatory response and vascular function.