Objective: To explore the structure of coping styles in job-hunting of university students after first interview and study the relationship between coping styles and personality traits.Methods: 622 university graduates completed coping styles questionnaire and 238 of them completed QZPS-SF.Results: SPSS 10.0 was applied to analyze the structure of coping styles and the relationship between coping styles and personality traits.Conclusion: The study tends to support the bi-dimensional structure of coping styles and personality traits were the important determinants of two dimensions of coping styles.

Objective To determine MIF expression in normal colorectal mucosa,colorectal adenoma and colorectal carcinoma, and the relationship between MIF and the clinical pathologic features of colorectal carcinoma.MethodsMIF expression was determined by immunohistochemical staining ELISA was used to detect the level of MIF in serum samples. Results The percentage of MIF expressing epithelial cells and MIF positive expression intensity were progressively increased in normal colorectal mucosa, colorectal adenoma and colorectal carcinoma. There was significant difference among three groups (P

Purpose The study about the CT manifestations of primary colorectal signet-ring cell carcinoma is rarely reported by now, the purpose of this study is to explore the CT findings of primary colorectal signet-ring cell carcinoma, to improve the radiology acknowledge about it. Materials and Methods CT findings of 46 patients with primary colorectal signet-ring cell carcinoma and 46 patients with colorectal adenocarcinoma confirmed by surgery and pathology were retrospectively analyzed, the differences of age, gender, tumor location, length and thickness of the involved intestinal wall, the thickening pattern of the intestinal wall, the contrast-enhanced form, the peri-intestinal invasion, the occurrence of intestinal obstruction and metastasis of other organs were compared between the two groups. Results Compared with the colorectal adenocarcinoma group, patient age of colorectal signet-ring cell carcinoma group was younger (t=5.23, P<0.001), and involved intestinal wall was longer and thicker (t=4.78 and 5.76, P<0.001). There were statistically significant differences of focal thickening form, contrast-enhanced level, peri-intestinal invasion, with or without peritoneal metastasis difference between the two groups (χ2=54.29, 11.89, 30.17 and 16.51, P<0.01 and P<0.001), while in gender, lesion location, occurrence of intestinal obstruction, lymph node metastasis, or liver metastasis, there was no statistically significant difference (χ2=0.18, 8.33, 0.10, 0.18 and 0.50, P>0.05). Conclusion Signet-ring cell carcinomas are often found in younger patients, their CT manifestations including a long length of concentric bowel wall thickening and is characterized by the target ring sign in contrast-enhanced scan, which often involves the peri-intestinal space with peritoneal metastasis and peri-intestinal lymph node metastasis.

OBJECTIVETo compare the difference in CT manifestations between primary colorectal mucinous adenocarcinoma and signet ring cell carcinoma in order to improve radiologic diagnosis.

METHODSClinicopathological data and CT findings of 109 patients with colorectal mucinous adenocarcinoma and 46 patients with primary colorectal signet-ring cell carcinoma confirmed by surgery and pathology from March 2008 to February 2015 in the Tumor Hospital of Yunnan Province were retrospectively collected. Differences in age, gender, tumor location, length and thickness of the involved intestinal wall, thickening pattern of the intestinal wall, lesion density, calcification, contrast-enhanced form, peri-intestinal invasion, occurrence of intestinal obstruction and metastasis of other organs were compared between the two groups.

RESULTSAmong 109 patients with colorectal mucinous adenocarcinoma, 68 were men and 41 were women with a mean age of (56.8±15.4) years. Among 46 patients with primary colorectal signet-ring cell carcinoma, 26 were men and 20 were women with a mean age of (42.9±15.6) years. Compared with mucinous adenocarcinoma group, signet-ring cell carcinoma group showed more concentric bowel-wall thickening[93.5%(43/46) vs. 81.6%(89/109), χ=9.19, P=0.030], higher lesion density [(42.0±3.0) Hu vs. (28.5±1.5) Hu, t=37.30, P=0.000], more marked enhancement [54.3%(25/46) vs. 12.8%(14/109), χ=35.21, P=0.000], less vast-low-density region in enhanced CT imaging[2.2%(1/46) vs. 45.0%(49/109), χ=73.31, P=0.000] and more severe peri-intestinal invasion [41.3% (19/46) vs. 17.4%(19/109), χ=10.25, P=0.006]. Calcification was found in 18.3%(20/109) of mucinous adenocarcinoma cases, but was not found in signet-ring cell carcinoma cases (χ=9.69, P=0.002). Target ring sign in contrast-enhanced scan was observed in 15.2%(7/46) of signet-ring cell carcinoma cases, while in none of mucinous adenocarcinoma cases (χ=17.37, P=0.000). There were no statistically significant differences in lesion location, length and thickness of the involved intestinal wall, occurrence of intestinal obstruction, lymph node metastasis, liver or peritoneum metastasis between two groups(all P>0.05).

CONCLUSIONSSignet-ring cell carcinoma is often found in younger patients, whose CT manifestation is characterized by the target ring sign in contrast-enhanced scan, while primary colorectal mucinous adenocarcinoma is often in older patients, whose CT manifestation is characterized by calcification in unenhanced scan and low density region in enhanced CT show.

Adenocarcinoma, Mucinous ; diagnostic imaging ; pathology ; Adult ; Age Factors ; Aged ; Calcinosis ; diagnostic imaging ; pathology ; Carcinoma, Signet Ring Cell ; diagnostic imaging ; pathology ; China ; Colorectal Neoplasms ; diagnostic imaging ; pathology ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Tomography, X-Ray Computed ; methods

Objective To establish a prognostic model for lung adenocarcinoma(LUAD)based on genes associated with the disulfidptosis(DS)pathway,and to elucidate its potential biological mechanisms.Methods LUAD-related gene sequencing and clinical information were sourced from public databases.The correlation between results of gene set variation analysis(GSVA)and mRNA expression in The Cancer Genome Atlas(TCGA)dataset was used to screen genes that were signifi-cantly active in the disulfur death(DS)pathway.The Least Absolute Shrinkage and Selection Opera-tor(LASSO)analysis and Random Forest(RF)algorithm were employed to screen out DS pathway prognosis-related genes(DPRGs)and multivariate Cox regression analysis was used to construct risk score(RS)model,which was validated using external GEO datasets.The samples were divided into high and low-risk groups based on the median score of RS.A protein-protein interaction(PPI)net-work corresponding to 7 DPRGs was established,with LDHA identified as the protein with the most interactions,thereby further investigating its function and expression patterns.Results In this study,7 DPRGs were screened,including SLC2A1,LDHA,SNAI2 and ACO2,FGF12,ANP32B and ST13.The prognostic model constructed based on these genes exhibited high validation efficiency.Kaplan-Meier survival analysis revealed significant differences in overall survival of patients between high-risk group and low-risk group in four datasets.Differential expression gene enrichment analysis be-tween the high-risk and low-risk groups showed that these genes were enriched in pathways such as the p53 signaling pathway and cell cycle.Results of real-time quantitative polymerase chain reaction(qRT-PCR)and immunohistochemistry indicated that LDHA expression levels were elevated in LUAD tissue compared to normal tissues.Conclusion The LUAD model established based on DPRGs can effectively predict patients'prognosis,potentially offering insights into the treatment and prognosis of LUAD patients.

Objective To establish a prognostic model for lung adenocarcinoma(LUAD)based on genes associated with the disulfidptosis(DS)pathway,and to elucidate its potential biological mechanisms.Methods LUAD-related gene sequencing and clinical information were sourced from public databases.The correlation between results of gene set variation analysis(GSVA)and mRNA expression in The Cancer Genome Atlas(TCGA)dataset was used to screen genes that were signifi-cantly active in the disulfur death(DS)pathway.The Least Absolute Shrinkage and Selection Opera-tor(LASSO)analysis and Random Forest(RF)algorithm were employed to screen out DS pathway prognosis-related genes(DPRGs)and multivariate Cox regression analysis was used to construct risk score(RS)model,which was validated using external GEO datasets.The samples were divided into high and low-risk groups based on the median score of RS.A protein-protein interaction(PPI)net-work corresponding to 7 DPRGs was established,with LDHA identified as the protein with the most interactions,thereby further investigating its function and expression patterns.Results In this study,7 DPRGs were screened,including SLC2A1,LDHA,SNAI2 and ACO2,FGF12,ANP32B and ST13.The prognostic model constructed based on these genes exhibited high validation efficiency.Kaplan-Meier survival analysis revealed significant differences in overall survival of patients between high-risk group and low-risk group in four datasets.Differential expression gene enrichment analysis be-tween the high-risk and low-risk groups showed that these genes were enriched in pathways such as the p53 signaling pathway and cell cycle.Results of real-time quantitative polymerase chain reaction(qRT-PCR)and immunohistochemistry indicated that LDHA expression levels were elevated in LUAD tissue compared to normal tissues.Conclusion The LUAD model established based on DPRGs can effectively predict patients'prognosis,potentially offering insights into the treatment and prognosis of LUAD patients.