Objective:To explore the experience and feelings of hip and knee replacement patients participating in the enhanced recovery after surgery (ERAS) model during hospitalization, so as to provide a reference for the improvement of ERAS perioperative and continuous nursing plans.Methods:From August to November 2019, purpose sampling was used to select 15 patients undergoing hip and knee replacement who were admitted to the Department of Joint Surgery of a ClassⅢ Grade A hospital in Guangdong Province for the semi-structured interview. Colaizzi's 7-step analysis method on phenomenology was used to analyze, summarize and refine the themes of the collected interview data.Results:The experience and feelings of joint replacement patients participating in the ERAS model during hospitalization can be summarized into 4 themes, namely uncertainty of information, being worried about the treatment effect, insecurity of early discharge, the contradiction between the desire to return and lack of confidence.Conclusions:Patients participating in ERAS had a short hospital stay after hip and knee replacement, and could not fully digest the information provided by the medical and nursing staff. Patients were also worried that they would not be able to cope after being discharged from the hospital. Clinical medical and nursing staff should fully evaluate the patient's readiness for discharge, provide personalized guidance, perfect out-of-hospital continuous nursing services and improve the patient's experience of early discharge.

Stroke is considered a leading cause of mortality and neurological disability, which puts a huge burden on individuals and the community. To date, effective therapy for stroke has been limited by its complex pathological mechanisms. Autophagy refers to an intracellular degrading process with the involvement of lysosomes. Autophagy plays a critical role in maintaining the homeostasis and survival of cells by eliminating damaged or non-essential cellular constituents. Increasing evidence support that autophagy protects neuronal cells from ischemic injury. However, under certain circumstances, autophagy activation induces cell death and aggravates ischemic brain injury. Diverse naturally derived compounds have been found to modulate autophagy and exert neuroprotection against stroke. In the present work, we have reviewed recent advances in naturally derived compounds that regulate autophagy and discussed their potential application in stroke treatment.