Objective To develop a continuous temperature monitoring device for the infant,with the function of high temperature alarm.Methods The comparator and counter of MSP430F435 SCM and some peripheral circuits was applied to high-precision temperature measurement,and then the data were stored in the flash of MSP430F435 SCM.Results The device could display realtime temperature and alarm in case of abnormal temperature,which made continuous monitoring of 30 days realized.Conclusion The device,being low-cost,low-power-consumption and low-volume,is worth popularizing for dynamic monitoring of infant temperature.

Objective To evaluate the efficacy and safety of olopatadine hydrochloride for the treatment of chronic idiopathic urticaria (CIU). Methods A multicentre, double-blind, randomized, parallel-group, controlled clinical trial was conducted. A total of 144 patients with CIU from 3 research centers were enrolled into this study, and randomly and equally divided into a test group and a control group. The test group administrated olopatadine hydrochloride 5 mg twice a day for 28 consecutive days, while the control group administrated levocetirizine hydrochloride 5 mg in the forenoon and a placebo tablet of olopatadine hydrochloride 5 mg in the afternoon for 28 consecutive days. The symptom score reducing index(SSRI)served as the primary outcome, and global assessment score for efficacy and total response rates as the secondary outcome. Results Totally, 137 patients completed the trial, including 70 in the test group and 67 in the control group. As intention-to-treat analysis showed, there were no significant differences in the total response rate between the test group and control group on day 7 (64.29% (45/70)vs. 56.72%(38/67), P > 0.05), 14(82.86%(58/70)vs. 74.63%(50/67), P > 0.05), or 28(87.14%(61/70)vs. 77.61%(52/67), P >0.05)after start of treatment. The SSRI was significantly higher in the test group than in the control group after 4 weeks of treatment(82.67% ± 22.70% vs. 70.51% ± 32.07%, P < 0.05). In addition, no significant difference was observed in the incidence of adverse reactions between the test group and control group(33.80%(24/71)vs. 27.94%(19/68), P > 0.05), and adverse reactions mainly included lethargy, dry mouth, fatigue, etc. Conclusion Olopatadine hydrochloride is effective and safe for the treatment of CIU.

Objective: To research lung infection related factors in proximal femoral fractures inpatient according to thehome page of its medical cases. Methods: The medical home pages of entire proximal femoral fracture cases from January1, 2003 to December 31 was extracted from the database of Chinese Academy of Traditional Chinese Medicine WangjingHospital. s medical information system. The information is verified and cleaned to build an Excel database with allavailable information. Logistic multivariate binary analysis was used to identify the related risk factors of pulmonaryinfection. The age of patients, the admission duration, chronic respiratory disease and using of traditional Chinese herbsare all closely related to pulmonary infection. Results: Logistic multivariate binary review found that the factors affectinglung infection were age, length of hospitalization days, chronic respiratory diseases, and whether to use of Chinese herbalmedicine. Conclusion: Under the premise conditions, patients with proximal femoral fractures should be allow to shortenthe length of time or early surgery. For elderly patients, and patients with chronic respiratory diseases, measures shouldbe taken as early as possible to prevent the onset of lung infection. The use of Chinese herbal medicine for prevention andtreatment of pulmonary infection is recommended, namely the combination of Traditional Chinese Medicine and westernmedicine in prevention and treatment of pulmonary infection.

Objective To explore the application effects of the quality control circle activities in improving the qualified rate of venous blood specimens.Methods We imported the concept of quality control circle (QCC),found the QCC group,designed the questionnaire of specimen inspection,analyzed the cause of the unqualified samples,formulated and implemented the improvement measures.Results The qualified rate of venous blood specimens was increased from 90.33％ to 97.16％.The process of the venous blood specimen collection was standardized.The ability of nurses on finding and solving the problems was enhanced.The nurses who joined the QCC group were investigated by the questionnaire with 6 questions,which scored from 1 to 6 points.The team spirit,working passion,responsibility and honor,QCC method,creativity and the ability of self-presentation were improved significantlyafter applying QCC.Conclusions The QCC activities have made significant effect in improving the qualified rate of venous blood specimen.The venous blood specimen collection process has further standardized,and the ability of nursesis also improved.

Objective:To investigate the role of concurrent chemoradiotherapy in the treatment of limited-stage small cell lung cancer (LS-SCLC) and the impact of the number of chemotherapy cycle during radiotherapy (RT) on clinical prognosis.Methods:Patients with LS-SCLC treated with definitive radiotherapy from May, 2008 to September, 2016 were included in the study. The primary endpoint was overall survival (OS), which was calculated from the start of treatment to the date of death or last follow-up. The effect of the number of concurrent chemotherapy cycle and other clinical factors on clinical efficacy was analyzed. Survival analysis was performed with Kaplan- Meier method, and multivariate analysis was performed with Cox regression model. Results:Three hundred and seventeen patients were eligible for the analysis. Among them, 129 patients received sequential chemoradiotherapy and 188 patients received concurrent chemoradiotherapy. Among patients receiving concurrent chemoradiotherapy, 86 patients received 1 cycle of concurrent chemotherapy and 102 cases of 2 cycles of concurrent chemotherapy. The median follow-up time was 22.47 months. Multivariate survival analysis showed that only clinical stage, timing of RT administration and prophylactic cranial irradiation (PCI) were the independent prognostic factor for OS. The median OS in patients who received 1 cycle and 2 cycles of concurrent chemotherapy during RT were 33.8 months and 30.4 months ( P=0.400). No matter in elder patients or in younger patients, in early RT group or in late RT group and application of PCI or not, the number of concurrent chemotherapy cycle exerted no significant impact on OS. The incidence of grade 3 or above adverse events was 20% in the 1-cycle concurrent chemotherapy group, and 13.7% in the 2-cycle concurrent chemotherapy group. Conclusions:Concurrent chemoradiotherapy is the standard treatment of LS-SCLC. Two cycles of concurrent chemotherapy during RT is not necessarily superior to 1 cycle of concurrent chemotherapy. The optimal number of concurrent chemotherapy cycle during RT need to be studied in a large prospective randomized clinical trial.

Objective To explore the effect of quality control circle activities in correctly rate of intravenous fluid storage .Methods Six nurses from cardiovascular surgery ICU volunteered to form a “circle”and established the activities theme of “improving correctly rate of intravenous fluid storage”.The reason of low correctly rate in intravenous fluid storage was found and analyzed , then, the rectification measures were formed and implemented.Results The correctly rate of intravenous fluid storage was 82.35%after the quality control circle activities and 17.65%before the intervention , which was increased 64.70%.The application of quality control circle, team spirit, professional knowledge , problem solving skills and nursing quality after the quality control circle activities were significantly improved compared than before ( t =11.612,2.561,2.719,7.694, 7.478, respectively;P<0.05).Conclusions The quality control circle activities can not only improve the correctly rate of intravenous fluid storage , but also can improve the team spirit and quality management .

Objective:To establish a TAL gel-clot bacterial endotoxin test for aluminum hydroxide adjuvant.Methods:According to the bacterial endotoxin test in general chapter 1143 of the Chinese Pharmacopoeia 2020,pre-interference test was performed using 3 types of buffer solutions and Ca-Mg additive by orthogonal design.The interference test and sample preparation validation were carried out using different batches of aluminum hydroxide adjuvant from 2 TAL manufacturers.Results:No interference was obtained through pre-interference test.Under the validated conditions,aluminum hydroxide adjuvant combined with phosphate buffered saline and Ca-Mg additive was employed to remove interference in bacteria endotoxin test.Conclusion:The established TAL gel-clot method is applicable to bacterial endotoxin test for aluminum hydroxide adjuvant.

This study was aimed to analyze the application of non-pharmacotherapy in treating cervical radiculopathy (CR) in real-world,and to provide clinical reference for CR non-pharmacotherapy.The clinical real-world data of CR was extracted by using information sharing system of traditional Chinese medicine (TCM) and clinical research.Six hundred and twenty-eight inpatients and outpatients with CR were enrolled from December 2012 to July 2014 in the information system database of Wangjing Hospital.Basic characteristics of the non-pharmacotherapy groups were analyzed by statistical description method.The node degree and mutual information value were recorded for non-pharmacotherapy application of all patients by using liquorice software.Complex network diagrams were generated.The results showed that 47％ of CR patients received non-pharmacotherapy (294/628),including 67 males and 227 females.The average age of patients was 49 years old,and the prevalence of the disease was the highest from 45 to 65 years old.In all patients,the usage of manipulation and cervical traction was higher,and the combination of manipulation and acupuncture was the most.Within outpatients,the proportion of cervical traction was higher,and the combination of manipulation and acupuncture was the most frequently.Within inpatients,the proportion of manipulation and cervical traction was higher,and the combination of comprehensive physical therapy and exercise therapy was the most frequently.It was concluded that non-pharmacotherapy has been commonly used in clinical treatment of CR.Cervical traction and manipulation was the widest applications.The combination treatment was in wide application.Future studies should increase the sample size of CR patients from different regions,and enhance gradually the level of evidence of clinical research for non-pharmacotherapy treating CR.

Objective: Analyze the clinical application rule of Chinese patent medicine in cervical radiculopathy (CR) .Method: The clinical real-world data of CR were extracted by using information sharing system of traditional Chinese medicine and clinical research. Six hundred and twenty-eight inpatients and out patients with CR were enrolled from December 2012 to July 2014 in the information system database of Wangjing Hospital. The correlation analyses and mutual information value were recorded for Chinese patent medicine therapy application of all patients by using liquorice software. Complex network diagrams were generated. Result: Yuxuebi capsule and Jingshu granule is the highest frequency in application of Chinese patent medicine. Jingshu granule and Cobamamide for injection were the highest frequency in combined application of Chinese patent medicine and western medicine. Association frequency was 822, mutual information value was 268.07. Biqi capsule and Daiwenjiu cream were the highest frequency in combined application of Chinese patent medicine and topical drugs. Association frequency was 384, mutual information value was1754.76. Conclusion: The basic treating principle for CR was promoting blood circulation and removing blood stasis. The efficacy and safety of combined Chinese patent medicine with other medicine need further research