Objective To analyze the effect of Ligustrazine combined with cephalosporin on the elderly patients with acute attack of chronic bronchitis. Methods From April 2015 to May 2017 selected 72 patients with chronic bronchitis acute attack were divided into group A and groupB according to the different treatment options, 36 cases in each group. Group B were received single cephalosporin antibiotics, while group A were given ligustrazine combined with cephalosporin antibiotics. The improvement of cough and other symptoms and the antipyretic time and other indexes were compared in the two groups. Results The time of disappearance of the positive signs of the lung, the antipyretic time and the time of cough disappearance in group A were significantly shorter than those in group B(P<0.05). The total effective rate in group A was 94.44％, which is significantly higher than the 72.22％ in group B(P<0.05). Conclusion Ligustrazine combined with cephalosporins on the treatment of the elderly patients with acute attack of chronic bronchitis can significantly improve the curative effect, which is worthy of clinical application.