Objective To explore the demand of nursing students with different nationalities and different levels for the order-oriented nursing talent cultivation mode, so as to provide reference for the establishment of order-oriented nursing talent cultivation mode in Xinjiang. Methods From January to April 2017, a total of 801 nursing students from the School of Nursing in Xinjiang Medical University were selected by cluster sampling method and investigated with "the Demand for Order-oriented Nursing Talent Cultivation Mode Questionnaire". Results The two reasons for the nursing students in different nationalities and different levels were the good employment situation (83.77%) and the wishes of the family members (68.29%). There were statistical differences of the willingness of participating in the order-oriented nursing talent cultivation mode among the nursing students with different nationalities and educational background (P<0.01). There was no statistical difference in the choice of the order hospital between the Han nationality undergraduate students and the minority undergraduate students (P>0.05). The difference of the choice of the order hospital between Han nationality junior college students and minority junior college students was statistically significant (P<0.01). Conclusions It is urgent to establish a customized nursing talent cultivation mode based on students' employment orientation and training according to the needs of employers, so as to improve the level of medical care service in Xinjiang region.

Nucleotide excision repair was a complex biochemical process that involved in the repair of many kinds of DNA damage. Previous study suggested that xeroderma pigmentosum group C (XPC) gene played an important role in the process of DNA damage repair. This study aimed to explore the influence of XPC gene polymorphism on the prognosis of patients with colorectal cancer (CRC) who were treated with capecitabine-related adjuvant chemotherapy. METHODS: A total of 158 patients with CRC who received surgical resection and capecitabine-based adjuvant chemotherapy were included in this study consecutively. Baseline clinical characteristics of patients were collected and analyzed. Additionally, peripheral blood specimens of the patients were collected for polymorphism analysis of XPC gene and mRNA expression of XPC, respectively. The association analysis between XPC polymorphism and prognosis and mRNA expression was performed. Cox regression analysis was used for multivariate adjustment. RESULTS: Prognostic data in the 158 patients with CRC who received capecitabine-based adjuvant chemotherapy was collected retrospectively. The median follow-up duration of the patients was 5.0 years (range: 0.25-7.5 years). The median DFS and OS of the 158 patients with CRC was 4.5 years and 5.7 years, respectively. XPC polymorphism analysis suggested that rs2228001 was of clinical significance. The prevalence of rs2228001 polymorphism among CRC patients was: TT genotype 86 cases (54.4%), TG genotype 60 cases (38.0%) and GG genotype 12 cases (7.6%), resulting in a minor allele frequency of 0.27, which was in accordance with Hardy-Weinberg equilibrium (P=0.733). TG and GG genotypes were merged in the subsequent analysis. The prognostic results exhibited that the median DFS of patients with TT genotype and TG / GG genotype was 4.5 and 5.7 years, respectively (c