Objective: To explore the effect of introducing multi-dimensional care strategy based on the concept of cognitive goal implementation in patients with femoral head necrosis replacement. Methods: From April 2016 to July 2018, 94 patients with femoral head necrosis were treated in Hainan Third People's Hospital. According to the digital table, the clinical subjects were named as study group and control group, 47 cases each. Among them, the control group carried out traditional intervention, while the research group carried out multi-dimensional care strategy based on the concept of cognitive goal implementation. The self-management ability, quality of life and satisfaction of the two groups were compared before and 4 weeks after the intervention. Results: After intervention, the scores of life behavior, rest and sleep, exercise, diet, medication compliance, self-monitoring, psychological counseling and regular reexamination in the study group were (2.0 ± 0.6), (1.9 ± 0.5), (1.8 ± 0.3), (2.0 ± 0.5), (2.4± 0.7), (2.0 ± 0.5), (2.1 ± 0.7) and (2.1 ± 0.6) respectively, which were higher than those in the control group (1.6 ± 0.4). There were significant differences in scores (t = 10.268-20.369, P<0.05). The scores of physiological function, physiological function, social function, mental health, emotional function, vitality, somatic pain and general health in the study group after intervention were (80.6 ± 6.5), (43.7 ± 4.2), (75.1 ± 6.1), (69.5 ± 5.1), (50.9 ±4.4), (66.5 ± 5.0), (79.3 ± 5.2) and (65.9 ± 6.0) respectively, which were higher than those in the control group (67.3 ± 4.2).) There were significant differences in scores (t = 11.803-18.277, P<0.05). The good rate of target implementation in the study group was 89.4% (42/47), which was higher than that in the control group (65.9% (31/47). The difference was statistically significant (χ² = 16.782, P<0.05). The nursing satisfaction of the study group was 97.9% (45/47), higher than that of the control group 85.1% (40/47). The difference was statistically significant (χ²=4.919, P<0.05). Conclusion Multidimensional care strategy based on the concept of cognitive goal execution can improve self-care ability and quality of life of patients with femoral head necrosis replacement, and improve patient satisfaction.