1.Study on alcohol extraction process of Rhizoma Chuanxiong
Chinese Traditional Patent Medicine 1992;0(03):-
Objective: To ascertain the condition for extracting tetramethylpyrazine from Rhizoma Chuanxiong with alcohol. Methods: With the transferring rate of tetramethylpyrazine as index, the optimum extraction condition for the first time was selected by uniform test, and the times of extraction was studied. Results: Taking 80% alcohol as solvent, Rhizoma Chuanxiong was extracted two times with 8 and 6 times volume of alcohol for 2hr and 1.5hr, respectively. In this condition, tetramethylpyrazine could be effectively extracted. Conclusion: The experimental results provided the basis for the ascertainment of extraction process of Rhizoma Chuanxiong preparation.
2.Clinical and Laboratory Study on Low Birth Weight Infant Supplemented with Human Milk Protein
Wei ZHANG ; Shimin ZHAO ; Xinghua HUANG
Chinese Journal of Perinatal Medicine 1998;0(03):-
Objective To evaluate the effect of supplementation with human milk fortifier (HMF) produced by human milk protein in low birth weight infants.Methods Eighty seven low birth weight infants undergoing neonatal intensive care were divided into 4 groups randomly,human milk +HMF 9307(enriched protein 6 g/L)and human milk;formula +HMF 9308(enriched SIgA 500 mg/L)and formula.Results The weight gain was faster in human milk+HMF 9307 group than that of human milk group(13.8 g?kg~(-1)?d~(-1).vs.9.4 g?kg~(-1)?d~(-1),P
3.Meta-analysis on Randomized Controlled Clinical Trials of Acupuncture and Moxibustion for Rheumatoid Arthritis
Xinghua ZHANG ; Bowen ZHU ; Binyuan ZHAO ; Xiaoguang QIN ; Xiaozheng DU
Chinese Journal of Information on Traditional Chinese Medicine 2015;(2):42-46
Objective To systematically assess the effectiveness and safety of acupuncture and moxibustion for treatment of rheumatoid arthritis. Methods Articles were searched from databases, i.e., CNKI, VIP, WanFang Data, CBM, Embase, and PubMed. Articles about RCT on acupuncture and moxibustion for rheumatoid arthritis and traditional medicine therapy were under meta-analysis. Results Totally 24 articles involving 2006 patients were included. The results of meta-analysis indicated that the overall effective rate of treatment in the group receiving acupuncture and moxibustion was higher than that in the drug group, with statistical significance [OR=2.73, 95%CI (2.18, 3.41), Z=8.78, P<0.000 01]. Sub-group analysis showed that:acupuncture and moxibustion showed statistical significance in decreasing serum RF levels compared with drug therapy [MD=-2.92, 95%CI (-5.60, -0.25), P<0.05]. Acupuncture and moxibustion showed statistical significance in decreasing serum ESR levels compared with drug therapy [MD=-2.99, 95%CI (-4.78, -1.21), P<0.05]. Acupuncture and moxibustion showed statistical significance in decreasing serum CPR levels compared with drug therapy [MD=-1.44, 95%CI (-2.44, -0.44), P <0.05]. Conclusion The overall effective rates of acupuncture and moxibustion for rheumatoid arthritis and the decreasing levels of RF, ESR, CRP are superior to drug therapy, but it still needs larger samples, multi-center, and high quality RCT to verify.
4.Effects of trypsin inhibitors on Wnt signaling pathway and cellular apoptosis
Yarui ZHAO ; Zongwei LI ; Xinghua WANG ; Zhuoyu LI
Cancer Research and Clinic 2011;23(10):718-720
The trypsin inhibitor is a kind of substance that can inhibit trypsin activity.It shares extensive physiological roles.The trypsin inhibitor not only inhibits the activities of many enzymes,but also has significant anti-cancer effects by suppressing cell invasion and promoting cell apoptosis.Wnt signaling pathway involves in the regulation of cell growth,proliferation and apoptosis.It also plays an important role in tumor development.This review focuses on the impacts of trypsin inhibitors on Wnt signaling pathway and tumor cell apoptosis.
5.Neuroprotective effects of minocycline in ischemic stroke
Zhenguang LI ; Xinghua CUI ; Jinbiao ZHANG ; Pengfei WANG ; Junwu ZHAO
International Journal of Cerebrovascular Diseases 2017;25(6):550-554
Minocycline is the second generation semisynthetic tetracycline antibiotics.A variety of animal models and clinical trials have shown that it has neuroprotective effect.Its mechanism is associated with inhibiting apoptosis, alleviating inflammatory reaction, reducing infarct volume, and alleviating vascular injury.This article reviews the neuroprotective effect of minocycline in preclinical phase and early clinical trials of acute ischemic stroke.
6.Clinical effect ofJiedu-Huayu granule for the degnue fever
Luping LIN ; Lingdi LIU ; Jiao LIU ; Lingzhai ZHAO ; Fuchun ZHANG ; Xinghua TAN
International Journal of Traditional Chinese Medicine 2017;39(5):402-407
Objective To observe the clinical effect ofJiedu-Huayu granule for the Dengue Fever (DF).Methods The patients with DF were randomly divided into the treatment group and control group. Both groups received the conventional treatment, and the treatment group addedJiedu-Huayu granule. The clinical effects were detected.Results At the baseline, the ALT and AST in the treatment were significantly higher than those in the control group (t=2.830,P=0.014;t=2.109,P=0.044). But after treatment, there was no difference between groups. The ALT in the treatment group showed a gradual change and AST recovery time showed short. Compared with control group, the concentration of sVCAM-1 in the treatment group was higher at baseline and the third day (t=2.780,P=0.018;t=2.130,P=0.460), but the concentration of MCP-1 desceased significantly on the 6th day (t=-2.164,P=0.042).Conclusions Compared with the western medicine, the treatment of western medicine andJiedu-Huayu granule could alleviate liver injure, shorten the recovery time, and reduce the concentration of sVCAM-1 and MCP-1.
7.Clinical observation of the double-J stent indwelling time in the treatment of ureteral complicated calculi post-ureteroscope
Wuxue LI ; Xinghua ZHAO ; Changbao XU ; Youzhi WANG ; Yuan LV ; Junjie LU
The Journal of Practical Medicine 2017;33(2):256-258
Objective To systematically evaluate the optimal indwelling time of double?J stent in the treatment of ureteral complicated calculi post?ureteroscopy. Methods A total of 161 patients with complicated ureteral calculi were enrolled in this study from August 2012 to August 2015. All patients received the treatment of ureteroscopic holmium YAG Laser lithotripsy and were randomly divided into 3 groups according to varied double?J stent indwelling time: group A < 2 weeks (n = 43),group B from 2 ~ 6 weeks(n = 67),and group C>6 weeks (n = 51). Complications of three groups were compared and the hydronephrosis after removing double?J stent was recorded. Results The rate of complications of group C was significantly higher than that in group A and group B (P<0.017). However,group A(10/43)has a higher rate of ureterostenosis after removing double?J stent compared with group B(4/67)and group C(3/51),while no statistical significance was observed between group B and group C. Conclusion The incidence of complications after lithotripsy increased with the indwelling time of double?J stent,but the short indwelling time would led to ureterostenosis. Therefore,the optimal indwelling time of double?J stent after flexible ureteroscopy was 2 to 6 weeks,and the indwelling time for patients with injury ureteral mucosa could be appropriately prolonged.
8.Clinical application of physical vibration lithecbole in upper urinary calculi after extracorporeal shock-wave lithotripsy
Changbao XU ; Youzhi WANG ; Xiaohan CHU ; Bin HAO ; Xinghua ZHAO ; Xiaofu WANG
Chinese Journal of Urology 2013;34(8):599-602
Objective To observe the curative effect of external physical vibration lithecbole (EPVL) therapy after extracorporeal shock-wave lithotripsy (ESWL) in upper urinary calculi.Methods A total of 133 patients of upper urinary calculi with randomly divided into 2 groups after ESWL therapy during the period of 2012 October to 2013 February.The EPVL group (66 cases) used the physical vibration lithecbole treatment,and the natural lithecbole group (67 cases) used the method by drinking water,adding exercise and other natural lithecbole method.Of the EPVL group,6 of the stones were located in the upper or middle calyx,13 in renal pelvis,16 in lower renal calyx and 31 in ureter,the stone diameter was 10-15 mm.Of the natural lithecbole group,8 of the stones were located in the upper or middle calyx,17 in renal pelvis,15 in lower renal calyx and 27 in ureter,the stone diameter was 10-15 mm.The clinical data of the curative effect,side-effect,and complications were collected and analyzed systematically.Results In the EPVL group,the average times of lithagogue treatment was 2.6 times,51 patients (77%) expelled stones on the day of lithecbole,and the stone free rate in a week was 79% (52/66).Especially,81% (13/16) of the lower renal calyx expelled stones on the day of lithecbole,and the stone free rate in a week was 88% (14/16).Whereas,30 patients (45%) in the natural lithecbole group expelled stones on the day of ESWL,and the stone free rate in a week was 49% (33/67) ; the lower renal calyx stone expulsion rate on the day of ESWL was 33% (5/15),and the stone free rate in a week was 40% (6/15).The curative effects were significantly different between the 2 groups (P< 0.05).There were no serious complications in both groups.Conclusions EPVL machine can significantly promote the stone expulsion after ESWL.Compared with traditional methods,EPVL therapy has a better curative effect,especially on lower renal calyx stones.EPVL is a safe and noninvasive treatment.
9.Skinfold thickness of Han adults in Jiangsu province
Xinghua ZHANG ; Lianbin ZHENG ; Keli YU ; Dapeng ZHAO ; Zhibo WANG ; Yang WANG ; Wenguo RONG ; Xiaorui ZHANG
Acta Anatomica Sinica 2014;(4):578-581
Objective To study the characteristics of skinfold thickness of Han adults in Jiangsu province . Methods The skinfold thicknesses of facial , subscapular , suprailiac , biceps , triceps and calf on 311 urban adults ( 157 males and 154 females) and 421 rural adults ( 213 males and 208 females ) of Han were investigated in Huaian city of Jiangsu province .Results The thickness of skinfold of urban females were thicker than that of urban males .Rural adults were the same .Han adults of Jiangsu showed the most significant differences between urban areas and rural areas .The values of six skinfold thicknesses of Jiangsu urban adults have positive correlation with age .Conclusion Han adults of Jiangsu show the most significant differences between genders .
10.Determination of the composition of kidney stones and prediction of the efficacy of extracorporeal shock-wave lithotripsy by X-rays
Changbao XU ; Bin HAO ; Youzhi WANG ; Xinghua ZHAO ; Liang YAN ; Xiaohan CHU ; Yuan LV
Chinese Journal of Urology 2012;33(1):13-15
Objective To evaluate the clinical value of determination of composition of kidney stones by shap and density and of prediction of the efficacy of extracorporeal shock-wave lithotripsy (ESWL) by X-rays. Methods The data of 358 patients were analyzed,with 204 male and 154 female and with 276 cases of solitary stones and 82 cases of multiple stones.Determine the composition of kidney stones by shap and density,predict the efficacy of ESWL by X-rays,and choose the appropriate method of treatment.Analyze stone chemical property by Infrared stone composition automatic analyzer to checkout the prediction results before surgeries. Results 339 cases were successful to remove stones after treatment.The prediction results of 308 cases (86.0%) were consistent in stone chemical property,and the preperative prediction results of 339 cases (94.7%) were consistent in ESWL efficacy. Conclusions Determination of composition of kidney stones and prediction of the efficacy of ESWL by X-rays were feasible.