OBJECTIVE:To strengthen the pharmacovigilance in hospital and to minimum the risk of drug in medical practice. METHODS: Literature optimization method and case analysis were applied for statemental analysis. RESULTS: Pharmacovigilance capacity of medical staff and propaganda and information exchange of pharmacovigilance should be strengthened. So the safety of clinical drug use could be improved. CONCLUSION: The leading role of hospital in pharmacovigilance should be full played to guarantee the safety of drug use.