Objective To investigate the safety and effectiveness of the spinous balloon application in coronary artery calcification.Methods A total of 80 patients with coronary artery calcification treated by per-cutaneous coronary intervention (PCI) were selected as the study subjects and divided into the control group and study group by adopting the random number table method,40 cases in each group.The control group a-dopted the routine balloon dilation and the study group adopted the spinous balloon dilation.The characteris-tics of stent implantation,intravascular ultrasound (IVUS) examination results and postoperative follow-up situation before and after coronary angiography and balloon dilation were compared between the two groups. Results The two groups all completed the PCI treatment.There were no statistically significant differences in the general data,coronary angiography and preoperative IVUS examination between the two groups (P>0.05).The number of balloon slippage in the study group was less than that in the control group[(2.72±1.23) times vs. (4.28±1.43) times,P<0.05],the operation time was shorter than that in the control group,and the difference was statistically significant[(64.34±8.73)min vs. (71.61±9.58) min,P<0.05]. There was no statistically significant difference in the anterior and posterior expansion balloon pressure of stent implantation,stent release pressure and stent length between the two groups (P>0.05).In the postop-erative IVUS examination,the immediate luminal obtaining area of the study group was larger than that of the control group[(3.76±0.87) mm2 vs. (3.33±0.67) mm2],and the minimum stent area was larger than that of the control group[(6.12±0.98) mm2 vs. (5.43±0.78)mm2],and the differences were statistically signif-icant (P<0.05),but there was no statistically difference in the poor rate of stent adhesion and loss of coro-nary dissection and blood vessel between the two groups (P>0.05).There were no statistically significant differences in the death cases,cases of stent restenosis,cases of non-fatal myocardial infarction and left ven-tricular ejection fraction during hospitalization and postoperative 6-month follow-up between the two groups (P>0.05).Conclusion The application of spinous balloon could increase the immediate lumen area and mini-mum stent implantation area,shorten the operation time and improve the stent implantation effect.