Objective:To preliminarily discuss the mechanism of Salvia miltiorrhiza and Rrhizoma alismatis in the prevention and treatment of lipid metabolism through regulating the imbalance of fibrinolytic system in rats with non-alcoholic fatty liver. Methods:The model of non-alcoholic fatty liver in rats was duplicated by high-fat diet feeding. Totally 60 adult Wistar rats were randomly divided into 6 groups (n=10 per group), namely the control group, the model group, Salvia miltiorrhiza group, Rrhizoma alismatis group, Salvia miltiorrhiza and Rrhizoma alismatis group,and Dongbaogantai group. The control group and the model group were given distilled water,and the other group was given Salvia miltiorrhiza,Rrhizoma alismatis,Salvia miltiorrhiza combined with Rrhizoma alismatis and Dongbaogantai,respectively. Rhizoma Alismatis decoction at high dose and low dose as well as Dongbaogantai was respectively adminis-trated in the designed groups,and the corresponding indices were detected 4 weeks later. Results:In the model control group,the con-tents of TC、TG、FFA in serum and the expression of PAI-1 were significantly elevated(P<0.05 or P<0.01),while the expression of t-PA was significantly reduced(P<0.01).After treatment,the contents of TC、TG、FFA in serum and the expression of PAI-1 in every treatment groups were reduced(P<0.01),while the expression of t-PA was elevated(P<0.01).Conclusion: Increasing the expres-sion of t-PA and reducing the expression of PAI-1 might be viewed as the mechanisms of Salvia miltiorrhiza and Rrhizoma alismatis in the prevention and treatment of non-alcoholic fatty liver disease.

Objective　The study was conducted to investigate single nucleotide polymorphism(SNP) in beta2-adrenoceptor(β2-AR) gene and the distribution of these identified SNPs in Chinese Han ethnic group.Methods　β2-AR gene was sequenced to detect SNPs by fluorescent labeling automatic sequencing method in 80 unrelated samples from territory of Dabie Mountain in Anhui province.Results A total of 8 SNPs were identified in length of 3.8 kb, including 5 SNPs in code region, 3 SNPs in regulatory region. Although the variations, -468C to G, -367T to C, -47C to T,-20T to C,+79C to G,+100G to A,+491C to T,+1098T to C have been identified in other ethnic groups, they have not been found in our study. The allele distribution of SNPs is in good unity with the Hardy-Weinberg equilibrium.Conclusion　The distribution of SNPs in β2-AR gene is not equable and the SNPs in different ethnic groups differ greatly. The allele distribution of SNPs conforms well to the Hardy-Weinberg equilibrium.

Objective To discuss value of color Doppler ultrasonography on antidiastole of thyroid adenoma and nodu-lar goiter. Methods A total of 80 cases of patients, who were given the medical treatment and pathologically diagnosed to have thyroid disease after operation in our hospital from June 2012 to June 2014 were selected, and were divided into antidiastole of thyroid adenoma group and nodular goiter group in accordance with pathologic results, with 40 cases of patients in each group. The patients in two groups were given color Doppler ultrasonography examination before medical treatment, and the size, shape, echo, relation with surrounding tissue and blood signal of thyroid diseases of pa-tients in two groups were observed, and the relation between index and disease were compared. Results The lesion of patients in antidiastole of thyroid adenoma group was mainly solitary, multiple occasionally, whose internal echo was mainly parenchymal, lesion edge and surrounding tissue had clear demarcation, and the envelope and acoustic halo was frequently seen, as well as the rich blood flow signals in surrounding and inner lesions. The lesion of patients in nodu-lar goiter group was mainly multiple, whose internal echo was mainly mixed, lesion edge and surrounding tissue had blurring demarcation, generally without envelope and acoustic halo. After comparing the lesion amount, internal echo, edge, envelope, acoustic halo and etc of patients in two groups, statistical differences appeared (χ2=8.72, 4.07,5.70,14.46,33.88,P<0.05 or P<0.01﹚. The patients in antidiastole of thyroid adenoma group [29 cases (72.5%﹚and 24 cases(60.0%﹚] had more rich cases of blood flow signals in surrounding and inner lesions than those in nodular goiter group[12 cases (30.0%﹚and 13 cases (32.5%﹚] (χ2=14.46、6.08,P<0.05 or P<0.01﹚. Conclusion Color Doppler ultrasonography plays an important value on the antidiastole of thyroid adenoma and nodular goiter, which provides sig-nificant basis for clinical diagnosis and treatment.