OBJECTIVETo study the effect of Daidzein on Antiarrhythmia.

METHODThe conventional antiarrhythmia methods were used.

RESULTDaidzein was remarkedly effective in preventing ventricular fibrillation induced by chloroform in mice and arrhythmia induced by aconitine in rats. The arrhythmia induced by adrenalin in rabbits was antagonized by Daidzein and it could obviously inhibit the action potential amplitude of isolated sciatic nerves in toads. And it could also prevent ventricular fibrillation induced by calcium chloride in rats, and obviously reduce the death rate of rats. Its anti-arrhythmic effect was dose-dependent.

CONCLUSIONDaidzein has obvious protective effect on drug-induced arrhythmia, which may be related to its inhibition of Na+ or Ca2+ influx and its blocking beta-adrenergic receptor.

Aconitine ; Animals ; Anti-Arrhythmia Agents ; therapeutic use ; Arrhythmias, Cardiac ; chemically induced ; prevention & control ; Bufo bufo ; Calcium Chloride ; Chloroform ; Epinephrine ; Female ; In Vitro Techniques ; Isoflavones ; isolation & purification ; therapeutic use ; Male ; Mice ; Phytotherapy ; Plants, Medicinal ; chemistry ; Pueraria ; chemistry ; Rabbits ; Rats ; Rats, Wistar ; Ventricular Fibrillation ; chemically induced ; prevention & control