Objective To explore the clinical effects of treating acute radioactive stomatitis with Xiufu Decoction by mouth-washing and oral-taking. Methods All 108 cancer patients were recruited into a treatment group (n=56) and a control group (n=52). The treatment group was treated with Xiufu Decoction for 15 days, and the control group was treated with Nystatin tabletsfor 15 days, 3 times/day. Results There was significant difference between the two groups in odynolysis time, the control of mycotic stomatitis, life condition, and overall effects (P<0.01 or P<0.05). All patients in the treatment group completed the whole course of radiotherapy; while 5 patients in the control group suspended the radiotherapy due to serious mouth ulcer. Conclusion Xiufu Decoction has the functions of enhancing immunity, fixing wound surface, relieving pain, improving diet and sleep, raising life quality, and safeguarding the process of radiation therapy, besides the decoction is safe and without toxic effect.

Objective To investigate the effects of rapamycin eluting stent(Cypher~(TM)) and metal bare stent on the prognosis and C-reactive protein(CRP) in elderly patients with acute myocardial infarction(AMI).(Methods The) immediate angiographic and clinic follow-up outcomes of 45 elderly patients with AMI reciving Cypher~(TM) and bare stent were retrospectively analyzed.CRP levels in Cypher~(TM) and bare stent groups were determined before implantation,6 h,1 d,7 d and 30 d after implantation.Clinical follow-up and major coronary events analysis were developed after operation.Results 27 rapamycin eluting stents were implanted in patients of Cypher~(TM) group and(26 bare) stents were implanted in patients of bare stent group.The Cypher~(TM) stents were successfully implanted with 100%.In patients of Cypher~(TM) group,no serious complications were found in the term of operation and in hospital.There was no restenosis,revascularization and events.In patients of bare stent group,except for(1 patients) with sudden death,angina pectoris occurred in 2 patients,repeat angiography showed that there were new lesions in other coronary arteries of these patients.Restenosis attacked in 2 patients.The concentrations of CRP in Cypher~(TM) and bare stent groups 6 h and 7 d after operation were much higher than that of(pre-operation (P

Objective To study the effects of mild hypothermia on secondary cerebral vasospasm and levels of endothelin(ET),calcitonin gene-related peptide(CGRP)in CSF and plasma in patients with subarachnoid hemorrhage(SAH).Methods 56 patients with SAH were randomly divided into mild hypothermia group and control group.Based on the routine treating method,patients of mild hypothermia group were treated with local mild hypothermia.The levels of ET,CGRP in CSF and plasma were detected before and after treatment.And the incidence rates of secondary cerebral vasospasm cases were compared between the two groups.Results(1)At 7 d,14 d after treatment,ET levels in CSF and plasma in mild hypothermia group were significant lower than those in control group(P

Objective To establish the quality control standard for Shuxiong soft capsule. Method Radix et Rhizoma Notoginseng, Rhizoma Chuanxiong were identified by TLC, and the content of Ginsenoside Rg1 were detdrmined by HPLC. Result The TLC sports developed was fairly clear. The HPLC method showed good repeatability, and the average recovery of quercitrin was 97.21%, RSD=0.65%. Conclusion The method is simple, accurate and can effectively control the quality of Shuxiong soft capsule.

Objective To screen the target genes that contribute to cisplatin resistance in ovarian cancer treatment. Methods Gene expression and methylation profiles of ovarian cancer cells that were sensitive or resistant to cisplatin with accession number GSE15709 were downloaded from GEO database. Differential expressed and methylated genes were identi?fied through associating packages in R. DAVID database to screen the enriched GO terms and pathways of the different ex?pressed genes between A2780 and A2780/DDP. Gene Set Enrichment Analysis (GSEA) of different gene was performed against DAVID database. Genes that exhibited difference in both expression and methylation profiles between the two types of ovarian cancer cells as well as genes that present contradictory profile between expression and methylation were verified via qRT-PCR. Results We found 416 different expressed genes and 281 methylated genes between the two types of ovari?an cancer cells respectively. These differential genes were rich in pathways of cell cycle, DNA replication, nucleus division , p53 signaling , and negative regulation of protein modification process etc. Four genes demonstrated contradictory profile be?tween expression and methylation in the two types of ovarian cancer cells and were verified by qRT-PCR. Conclusion Combination of bioinformatics and molecular biology is useful in the identification of target genes that contribute to resis?tance of cisplatin in ovarian cancer treatment and further reveal molecular mechanism behind it.

Objective To observe the influence of the insulation blanket applied in general anesthesia on the incidence of postoperative delirium.Methods 60 patients with elective laparoscopic cholecystectomy under generalanesthesia with ASA of grade Ⅰ-Ⅱ were selected.According to the random number table,the patients were divided into group A(without insulation blanket)and group B (with insulation blanket),each group in 30cases.The dosage and drug batch number of anesthetic drugs were same.Evaluated each patient using the confusion assessment method-chinese revised (CAM-CR).Recorded the number of cases of delirium for each group when 24 hours,48 hours, 72 hours after operation.Results The incidence of postoperative delirium in group A was 6.7%,which in group B was 0.0%.The incidence of postoperative delirium of group B was lower than group A (P <0.05 ).Conclusion Using insulation blanket to protect body temperature in perioperative operation can reduce the incidence of postopera-tive delirium in perioperative operation.

Cardiomyopathy, Dilated ; genetics ; Humans ; NAV1.5 Voltage-Gated Sodium Channel ; Sodium Channels ; genetics

[Objective] To investigate the clinical efficacy of nasal endoscopic assisted by-mouth low-temperature plasma radiofrequency ablation for treating the children with adenoid hypertrophy.[Methods] Seventy patients with adenoid hypertrophy were divided by random digits table method into treatment group and control group with 35 cases each.The patients in control group underwent traditional by-mouth adenoidectomy,while the patients in treatment group were treated with nasal endoscopic assisted by-mouth low-temperature plasma radiofrequency ablation.The operative time and intraoperative blood loss in two groups were calculated.The children were followed up for 6-12 months and the clinical efficacy of snoring,nasal obstruction and hearing and the postoperative complications were observed.[Results]The intrsoperative blood loss in treatment group was significantly lower than that in control group[(2.23±0.74)ml vs.(24.58±8.19)ml](t=19.733,P ＜ 0.01).The total efficiency of snoring,nasal obstruction and hearing in treatment group was 91.4％(32/35),82.9％(29/35)and 77.1％(27/35),respectively,and which was significantly higher than that in control group[68.6％(24/35),62.9％(22/35)and 57.1％(20/35)](x2 =5.354,5.293,5.421,P＜0.01).There,was no residual adenoid and adenoidal hypertrophy recurrence in treatment group,while the postoperative residual adenoid rate in control group was 91.4％(32/35),the adenoidal hypertrophy recurrence rate was 20.0％(7/35).There was significant difference in postoperative complication incidence between two groups(x2 =9.391,P ＜ 0.01).[Conclusions] Nasal endoscopic assisted by-mouth low-temperature plasma radiofrequency ablation for treating the children with adenoid hypertrophy has better clinical efficacy,less intraoperative blood loss,no postoperative residual and other complications.It is an ideal method for treating the children with adenoid hypertrophy and worthy of clinical application.

Objective To investigate the present situation and outcome of cardiopulmonary resuscitation (CPR) for pediatric in-hospital cardiopulmonary arrest and to analyze the prognostic risk factors.Methods Data were collected from October 2008 till October 2011 using Ustein style.Patients older than 28 days who received CPR were evaluated.Returning of spontaneous circulation(ROSC) more than 24 hours was the primary outcome.Neurological outcome was assessed by pediatric cerebral performance categories half year after discharge.Results Of the 36 patients,15 (41.7％) achieved sustained ROSC.Seven (19.4％) patients survived to discharge.Single factor analysis indicated that the beginning heart rhythm,defibrillation and original disease were significantly different between the two groups(P ＜0.05).The beginning heart rote of the patient in ROSC ＞ 24 h group was mostly sinus bradycardia.Patients who need defibrillation had bad prognosis.Patients with heart disease had a lower rate of ROSC ＞ 24 h.At half year follow-up study,4 patients had 1 or 2 score,1 patient had 4 and 1 had 5 score in the pediatric cerebral performance categories scales.Condusion The successful rate of CPR in our hospital was the same as that in developed country.The beginning heart rhythm,defibrillation and original disease were associated with the outcome.Most of the patients who survived to discharge had a good neurological outcome.

Humans ; Neck ; Solitary Fibrous Tumors