1.Towards Personalized Intervention for Alzheimer’s Disease
Peng XING ; Xing PEIQI ; Li XIUHUI ; Qian YING ; Song FUHAI ; Bai ZHOUXIAN ; Han GUANGCHUN ; Lei HONGXING
Genomics, Proteomics & Bioinformatics 2016;14(5):289-297
Alzheimer’s disease (AD) remains to be a grand challenge for the international commu-nity despite over a century of exploration. A key factor likely accounting for such a situation is the vast heterogeneity in the disease etiology, which involves very complex and divergent pathways. Therefore, intervention strategies shall be tailored for subgroups of AD patients. Both demographic and in-depth information is needed for patient stratification. The demographic information includes primarily APOE genotype, age, gender, education, environmental exposure, life style, and medical history, whereas in-depth information stems from genome sequencing, brain imaging, peripheral biomarkers, and even functional assays on neurons derived from patient-specific induced pluripo-tent cells (iPSCs). Comprehensive information collection, better understanding of the disease mech-anisms, and diversified strategies of drug development would help with more effective intervention in the foreseeable future.
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