Objective The diffferences of the cardiovasular transverse between sea-level and high altitude residents was analysed, by measuring thoracic great vessels diameter with CT scanning .Methods 100 cases residents of high altitude and 100 cases sea-level residents were scaned by CT in lung, and the cardiovascular and pulmonary arterial diameter were measured .Results In high altitude groupe the average transverse diameter(ATD) of aortic arch was (2.59?0.30)cm but in control groupe, ATD was (2.73?0.40)cm. The ATD of right pulmonary veins in high altitude was (1.00?0.30)cm but that of control was(1.19?0.34)cm. The ATD of left subpulmonary arteries in high altitude groupe was (1.30?0.28)cm and that of control was (1.2?0.43)cm.Conclusion The transverse diameter(TD)of pulmonary arteries was larger than those of the control . The TD of great arteries of systemic circuit and pulmonary veins were larger in sea-level residents than those of residents of high altitude.

It is important that the oral hospital establish a guarantee system of medical graduation clinical practice quality. Having experienced clinical education for many years,the hospital has formed a system in order to achieve objective management and process management organic unification,which can gradually promote the clinical practice quality.

Objective: To observe the protective mechanism of morroniside (an active component in Cornus officinalis) on the diabetic nephropathy (DN) mice induced by streptozocin (STZ) and aggravated by advanced glycation end products (AGEs). Methods: The DN mice were fed with high-AGEs fodders, and ig administered with aminoguanidine (0.1 g/kg), metformin (0.2 g/kg), captopril (0.02 g/kg), low-dose morroniside (0.02 g/kg), and high-dose morroniside (0.10 g/kg) for 12 weeks. After that, the fasting glucose, insulin, serum creatinine, urea nitrogen, serum and renal AGEs, 24 h urine protein, etc were measured, the RT-PCR method was used to detect the levels of receptor for advanced glycation end products (RAGE) mRNA, the Western blotting technique was used to test the protein expression levels, and the pathologic changes of mice pancreas and kidney were observed. Results: Morroniside could significantly decrease the fasting blood glucose levels, alleviate the symptoms of polydipsia, polyphagia, polyuria, and weight loss, increase the insulin production, and reduce the levels of 24 h urine protein, serum urea nitrogen, creatinine, serum and renal AGEs. Furthermore, morroniside could also anesis the lesions of pancreas and kidney and reduce the levels of RAGE mRNA and protein expression in renal cortex. Conclusion: Morroniside has the protactive effects on DN mice and high-dose morroniside was much better. The mechanism may be related to the reduced levels of AGEs and RAGE mRNA and protein expression.

Objective To develop the ribavirin purity certified reference material( CRM ) which has measurement traceability and high accuracy,and establish an effective method of evaluation. Methods The homogeneity and the stability were checked by differential scanning calorimetry(DSC). High performance liquid chromatography(HPLC)and DSC methods were used for purity determination of ribavirin. Results Ribavirin showed satisfactory homogeneity and stability. The certified value of ribavirin was 99. 5%with an uncertainty of 0. 4%(k=2,P=0. 95). Conclusion Ribavirin purity CRM obtained in this paper has been proven to be a national primary CRM with high accuracy and traceability,which can be used to validate analytical methods,improve the accuracy of measurement data,establish meteorological traceability of analytical results as well as control the quality of ribavirin in the pharmaceutical industry.

At present, there is a relative shortage of multimedia classroom resources of medical schools. Yan'an Hospital of Kunming Medical College proposed the new model of teaching methods of portable multimedia classrooms composed of MP5. According to the teaching practice and the results from the questionnaire, it is approved by the teachers and students.

Archives ; Humans ; Occupational Health

Humans ; Occupational Diseases ; epidemiology ; prevention & control ; Occupational Health Services

To meet the need of cultivating the high-quality medical personnel,we have ad-justed and reformed the content of the "Clerkship" teaching in obstetrics and gynecology and conducted the survey and research among teaching philosophy,training mode and management mechanism,and have obtained more satisfactory teaching result.

Clinical practice was an important part in the medical education.To improve the clinical education quality of obstetrics and gynecology,several methods were chosen to settle the problems such as setting up and perfecting the management mechanism,strengthening the construction of teachers and the cultivation of students’overall quality.

Objective To analyze the prognostic factors in patients with cervical squamous cell carcinoma of stage Ⅰb and Ⅱa treated by surgery,and to investigate their guid roles in available post-operation adjuvant therapy. Methods The clinicopathologic records of 306 patients with cervical squamous cell carcinoma of stage Ⅰb and Ⅱa who underwent radical hysterectomy and pelvic lymphadenectomy were retrospectively analyzed, and the prognostic factors were explored by univariate and multivariate methods. Independent prognostic factors were identified by COX proportional hazards regression model. Results The overall 5-year survival rate of these 306 patients was 78.1%. In univariate survival analysis, the poor prognostic factors included poor differentiation, positive pelvic lymph nodes, deep stromal invasion, parametrial extension, tumor size≥4 cm, and lymph vascular space involvement (P