1.Extracorporeal shock wave therapy for nonunion or delayed osseous union: Animal experiment and clinical follow-up
Chinese Journal of Tissue Engineering Research 2010;14(9):1625-1628
BACKGROUND:Extracorporeal shock wave (ESW) therapy is using principles of liquid-electric conversion and transfer to produce energy gradient difference and torsional tension in tissues with varied density.It is a matured technique in treating urinary and digestive system calculosis.However,the applications of ESW in treating nonunion or delayed osseous union are few.OBJECTIVE:To explore the therapeutic effects of ESW in treating nonunion or delayed osseous union by animal experiment and clinical verification.METHODS:The effect of ESW on periosteal metabolism was explored by focusing extracorporeal wave on bone tissues,and the autoradiography of H~(3-)TdR labeling rate was observed by animal experiment.ESW was used to treat nonunion patients (n=16) or delayed osseous union patients (n=16),and the follow-uP results were evaluated.RESULTS AND CONCLUSION:By autoradiography,the H~(3-)TdR labeling rate was greater in the experimental sides than that of the control sides at 1 and 2 weeks after operation (P<0.05-0.01),which confirmed that the mitotic activity of periosteal osteoblasts was increased,namely,endosteal osteogenesis was enhanced.Clinical verification results demonstrated that,at 16 weeks after operation,16 patients with delayed union were all cured,13 were cured among the 16 cases of nonunion,and the remained 3 cases had notably callus formation.No adverse events occurred in all cases.The results suggested that it is reliable to treat nonunion or delayed osseous union using ESW therapy.
2.Clinical Study on Xiaoxuan Kangfu Capsule in the Treatment of Psoriasis Vulgaris
International Journal of Traditional Chinese Medicine 2008;30(5):361-362
Objective To investigate the therapeutic effect of Xiaoxuan Kangfu capsule in treating psoriasis vulgaris. Methods All patients were divided into two groups randomly (60 patients in a control group and 60 patients in a treatment group). In the control group complex Qingdai capsule was given to the patients, with 4 pills for each time and 3 times daily. While in treatment group Xiaoxuan Kangfu capsule was given to the patients with 6 pills for each time and twice daily. 30 days consisted one treatment period for both groups. The patients undertook one to three treatment period according to the patients' pathogenetic condition. The rates of recovery and improvement and were compared. Results In the treatment group, 34 patients were cured (42.5%), and the total effective rate was 87.5%; while in the control group 14 patients were cured (7.5%), and the total effective rate was 72.5%. There was statistic difference between the two groups (P<0.05). The average heal time of the treatment group was shorter than that of the control group, showing statistic difference (P<0.05).Conclusion Xiaoxuan Kangfu capsule showed higher recovery rate, shorter healing time and lower recurrence rate in treating psoriasis vulgaris than complex Qingdai capsule. The treatment is deserving clinical spread.
3.Analysis and identification of IR on different parts ofCynanchumchinese R.Br
International Journal of Traditional Chinese Medicine 2015;(3):255-257
ObjectiveTo identify the chemical composition of stem, leaf and peel ofCynanchumchinese R.Br..MethodsFourier IR spectra, the second derivative spectrum and two-dimensional correlation spectroscopy were adopted to identify IR of different parts ofCynanchumchinese R.Br..ResultsIt was found that the IR spectra of the leaf was similar to that of the peel but was different from the stem. What’s more, in the second derivative spectra of the leaf, it showed that the absorption peak was strong at the position of 1 543 cm-1, 1 515 cm-1, 1 499 cm-1 and 1 467 cm-1, respectively and there existed carbonyl absorption peak at 1 738 cm-1 and 1 659 cm-1 in addition. Therefore, it was inferred that flavonoids were the major components while less in the stem and peel.ConclusionsThe differences of the three parts aboutCynanchumchinese R.Br. were studied through IR spectrum macroscopically, which provided reference for exploring the constituents and clinical medication.
5.The development tendency of modern implantology.
Chinese Journal of Stomatology 2003;38(4):241-243
9.The evaluation in hemotology analyzer detecting reticulocyte parameters
China Medical Equipment 2016;13(3):88-90
Objective:To investigate clinical value of the blood analyzer reticulocyte parameter in the diagnosis of anemia.Methods: 271 cases of anemia patients were divided into iron deficiency anemia(126 cases) and hemorrhagic anemia group(145 cases), namely the observation group; and other 50 healthy physical examinees were selected as the control group. SysmexXE-5000 automatic blood analyzer were used to detect the reticulocyte parameters, including reticulocytes(RET) ratio, high fluorescence reticulocytes(HFR) ratio of middle fluorescence reticulocytes(MFR) ratio and the immature reticulocytes(IRF) ratio.Results: Compared with the control group, the RET, HFR, MFR and IRF were significantly higher in the observation group. The sensitivity of iron deficiency anemia and blood loss anemia was 96.2% and 63.5%; the specificity of anemia was 96.0%.Conclusion: Detection of reticulocyte parameters can reflect the marrow hyperplasia patients with anemia. It has a high sensitivity and specificity in the diagnosis of various types of anemia, which has a high practical value in clinic.
10.Curative Effect of Phosphocreatine Adjuvant Treatment on Neonatal Hypoxic-Ischemic Myocardial Lesion
China Pharmacist 2016;19(6):1123-1125
Objective:To discuss the curative effect of phosphocreatine adjuvant treatment on neonatal hypoxic -ischemic myocardi-al lesion and its influence on serum IL-6 and myocardial enzyme .Methods:Totally 80 cases of newborns with hypoxic-ischemic myo-cardial lesion were divided into the observation group and the control group at random .The two groups were given the routine medical treatment, including maintenance of ventilation , warmth, water-electrolyte and acid-base balance, heart rate, blood pressure, nutrition support and etc, while the newborns in the control group were additionally given 250 mg· kg-1 1,6 diphosphate (FDP), ivgtt bid, for 10 days, while those in the observation group , were additionally given 1.0g phosphocreatine dissolved in 100 ml 0.9% normal saline (NS) on the basis of the treatment of the control group , ivgtt qd, for 10 days.The clinical curative effect and security were observed and the changes of serum IL-6 and myocardial enzyme in the two groups were compared .Results: The levels of LDH, CK, CK-MB and serum IL-6 in the two groups were obviously declined when compared with those before the treatment (P<0.05 or P<0.01), and the declining rate of the observation group was higher than that of the control group (P<0.05).The total clinical efficiency of the ob-servation group was higher than that in the control group after the medical treatment (P<0.05), and no serious untoward effect ap-peared in the two groups during the medical treatment .Conclusion: Phosphocreatine has significant curative effect on neonatal hy-poxic-ischemic myocardial lesion , which can effectively improve myocardial function of newborns and reduce myocardial enzyme and se -rum IL-6 levels.