[Objective]To summarize the academic experience of the first"National Medical Master"Professor HE Ren in the treatment of esophageal cancer choking.[Methods]By studying Professor HE Ren's academic works,distilling his academic experience in treating esophageal cancer with dysphagia,and conducting a frequency analysis of the prescriptions of 221 initial esophageal cancer patients to summarize the dosage regimen and frequently used drug pairs of Professor HE's treatment for esophageal cancer with dysphagia,with case histories provided for verification.[Results]The top herbs used in single prescriptions were milkvetch root,tangshen and spreading hedyotis herb,etc.The most frequently used herb pairs were tangshen+milkvetch root and root of valvate actinidia+spreading hedyotis herb,etc.Professor HE Ren treated patients according to three types of diagnosis:syndrome of intermingled phlegm and Qi,phlegm-stasis blocking and deficiency of both Qi and Yin,and gave the basic prescriptions of light-raising and diaphragm-inducing,pungent-perfuming and subduing and pungent-smoothing and nourishing,respectively.The common basic prescription herbs of syndrome of intermingled phlegm and Qi were ginger processed pinellia,radix bupleuri,cremastrae pseudobulbus,acquilaria leaven,combined spicebush root and nutgrass galingale rhizome.The common basic prescription herbs of phlegm-stasis blocking were cremastrae pseudobulbus,magnoliae officmalis cortex,ginger processed pinellia,sparganii rhizoma,curcumae rhizoma and Danshen root.The common basic prescription herbs of deficiency of both Qi and Yin were tangshen,milkvetch root,polyporus,Indian buead,lycii fructus and glossy privet fruit.The attached test case was the pain of choking diaphragm,phlegm and blood stasis,with the treatment of incense and blood collaterals,and it achieved a better effect.[Conclusion]The discussion of the three diseases of choking and diaphragm enriched HE Ren's diagnosis and treatment of choking and diaphragm in esophageal cancer,and the proposed treatments of light promotion and diaphragm benefitting,pungent aroma and descending,and pungent slippery moistening and nourishing provided useful references for the diagnosis and treatment of patients with various stages of esophageal cancer.

AIM: To evaluate the prophylactic effect of aminophylline on the pulmonary hypertension rebound reaction to exposure to NO in the hypoxic pigs. METHODS: The 10 pigs undergone Swan-Ganz catheter, the mPAP was measured with a Physio-recording instrument and PaO 2 was measured with a blood gas analyzer, when breathing NO for 30 minutes and suddenly stopping breathing NO, administing aminophylline 0.25 g, followed by 30 minutes with room air. The respiratory rate and heart rate were also monitorried with a Hewlett-Packard portable monitor. RESULTS: The mPAP of the acute hypoxic pig was induced significantly after breathing 10 -5 NO. When suddenly stopping breathing NO, the induced mPAP became more and more high, the level of the mPAP in 5 minutes was similar to the values before absorbing NO, the mPAP in 10 minutes was higher than values before absorbing NO, while the level of PaO 2 was lower than the values before absorbing NO; but suddenly stopping breathing NO, administing aminophylline, although the induced mPAP became high, the speed was slower than the controls, the level of the mPAP in 30 minutes still was lower than the values before absorbing NO. CONCLUSION: Aminophylline has preventive effects on the pulmonary hypertension rebound reaction to exposure to NO in the hypoxic pigs.

Objective:To investigate the efficacy of fixation through dual minimally invasive incisions and dual osseous channels with a loop titanium plate combined with a Dog-Bone titanium plate for acute Rockwood Ⅲ acromioclavicular dislocation in comparison with open reduction and fixation with a clavicular hook plate.Methods:A retrospective study was conducted to analyze the data of the 60 patients with acute type Ⅲ acromioclavicular dislocation who had been treated at Department of Orthopedics, Liaocheng People's Hospital from February 2019 to May 2022. There were 35 males and 25 females with an age of (43.2±8.0) years, and 34 left sides and 26 right sides affected. According to different surgical methods, they were divided into a double titanium plates group of 32 cases who had been treated by fixation through dual minimally invasive incisions and dual osseous channels with a loop titanium plate combined with a Dog Bone titanium plate and a hook plate group of 28 cases who had been treated by open reduction and internal fixation with a clavicle hook plate. The time from injury to operation was (2.1±1.3) d. The 2 groups were compared in terms of incision length, operation time, intraoperative bleeding, and visual analogue scale (VAS) pain score, Constant-Murley shoulder function score and the coracoclavicular distance on the affected side which were recorded preoperatively and at the last follow-up. Complications such as infection, loosening of internal fixation or secondary fracture were observed.Results:There was no statistically significant difference in the preoperative general data between the 2 groups, indicating comparability ( P > 0.05). All patients were followed up for (11.2±2.1) months. The incision length in the double titanium plates group [(3.5±0.3) cm] was significantly shorter than that in the hook plate group [(6.2±0.7) cm], and the intraoperative bleeding [(45.3±7.5) mL] in the former was significantly less than that in the latter [(64.1±6.2) mL] ( P < 0.05). However, there was no statistically significant difference in the operation time between the 2 groups ( P > 0.05). The VAS score [0.5 (0, 1.0) points] and Constant-Murley shoulder function score [(95.1±2.1) points] in the double titanium plates group were significantly better than those in the hook plate group [0.8 (0, 1.0) points, (86.0±4.4) points] at the last follow-up ( P < 0.05). However, there was no statistically significant difference between the 2 groups in the coracoclavicular distance on the affected side ( P > 0.05). Good acromioclavicular joint repositioning and fixation were achieved in all patients. There were no surgery-related complications except for sinus tract formation in one patient in the double titanium plates group. Conclusion:In the treatment of acute Rockwood Ⅲ acromioclavicular dislocation, fixation through dual minimally invasive incisions and dual osseous channels with a loop titanium plate combined with a Dog-Bone titanium plate is superior to open reduction and internal fixation with a clavicular hook plate, showing advantages of minimal invasion, better safety, less intraoperative bleeding, and faster joint function recovery.