Objective To observe the effects of stone needle on chronic obstructive pulmonary disease in acute exacerbation period (AECOPD). Methods One hundred and forty five cases of AECOPD were randomly divided into three groups. Patients in combined treatment group (n =49) received that stone needle hot compresses the back and Chinese herbal medicine besides routine treatment. Patients in Chinese herbal medicine group (n =48) received Chinese herbal medicine besides routine treatment. Patients in placebo group (n =48) received routine treatment. Results The effective rate of combined treatment group was 89.80%,and that of Chinese herbal medicine group was 85.42%,which were all significantly higher than which in placebo group (72.92%,P

OBJECTIVE:To provide reference for the standardization of package insert of common drugs for elderly patients. METHODS:Outpatient prescriptions in our hospital from 2013 to 2014 were collected,and common drugs of elderly patients(≥60 years old)were ordered by consumption sum,and package inserts of top 100 drugs were statistically analyzed for absent items. RESULTS:The 100 common drugs for elderly patients included 28 Chinese traditional drugs and 72 chemical drugs. The Chinese traditional drug had more absent items,mostly were pharmacokinetics and drug overdose(92.9%),medication of elderly patients (85.7%),drug interactions(78.6%)and pharmacological actions(50.0%);the proportion of contraindications(16/28),adverse re-actions(15/28) and precaution(9/28) with uncertainty was relatively high. Items of chemicals package insert were better than Chi-nese traditional drug,absent items were pharmacokinetics and drug overdose(5.6%),medication of elderly patients and pharmaco-logical actions (2.8%) and drug interactions (1.4%);the proportion of medication of elderly patients (16/72),drug interaction and drug overdose(12/72)with uncertainty was relatively high. CONCLUSIONS:The common problem existing in the drug manu-al is characterized by absence of usage for elderly,drug descriptions is not clear,etc. Package inserts should be further improved to strengthen its standardization.

AIM: To study the impacts of the myocardial connexin 43 degradation on conduction velocity during acute myocardial ischemia. METHODS: Studies were carried out in 16 dogs which were randomly divided into control group( n= 4) and ischemia group( n= 12). The acute myocardial ischemia was induced by ligation of the left anterior descending coronary artery. The conduction velocity of ischemic myocardium was determined. The content of Cx43 of the ischemic myocardium was examined by laser confocal microscopy with a double-label immunohistochemistry technique. RESULTS: (1)The Cx43 degraded rapidly during acute myocardial ischemia, and the conduction velocity of ischemic myocardium declined greatly; (2)The conduction velocity correlated positively with the Cx43 pixel density in each small region of ischemic myocardium; (3) The Cx43 pixel density decreased over 50% in the region which occuring permanent conduction block. CONCLUSION: These data suggest the degradation of Cx43 decreases the conduction velocity greatly during acute short time myocardial ischemia, and severe degradation of Cx43 would lead to permanent conduction block.

This study was aimed to find the fragmentation pathways of Schisandrin B using the Discovery Studio by electrospray ionization mass spectrometry (ESI-MSn). The first and multi-stage mass spectrum diagrams were obtained. The results showed that mass spectrometry fragments of Schisandrin B was analyzed under the positive mode, the cracking rings are mainly occurred, and free radicals such as H2O, -CH3 and -OCH3 were lost. It was concluded that this study enriched the mass spectral decomposition, and provided basis for the study on chemical constituents of lignan compounds.

Objective To review the survival outcomes in patients with endometrial stromal sarcoma(ESS)in Cancer Hospital，Peking Union Medical College，Chinese Academy of Medical Sciences，and to discuss prognostic factors and the role of post-operative adjuvant radiotherapy and chemotherapy.Methods Hospital records and pathology reports for 97 patients with ESS were reviewed.Among 97 patients，69 had low-grade ESS(LGESS)，16 had high-grade ESS(HGESS)and 12 had unclear grade.The median age at diagnosis was 44.0 years.The median follow-up time was 62 months(5-277 months).Atypical vaginal bleeding(43％)and prolonged and increased menses(36％)were the main symptoms.Results Totally 2-year and 5-year cumulative survival rates were 93％and 84％，respectively.Cumulative survival curves were significantly different between LGESS and HGESS，and so did cumulative survival curves between stage Ⅰ-Ⅱ and stage Ⅲ-Ⅳ(P＜0.05).Totally，34 patients(37％)had local or distant recurrence.The median time-to-recurrence(TTR)was 27 months.The recurrence rates of the patients with or without preserve of ovary were 89％and 24％，respectively(P=0.000).The local-control-rates of the patients who received or did not receive post-operative radiotherapy were 81％and 43％，respectively(P=0.011).Conclusions The prognosis of HGESS is obviously worse than that of LGESS.The risk of recurrence of patients with preserve of ovary was remarkably higher than that of patients without preserve of ovary.Postoperative radiotherapy could increase the local-control-rates.

Objective To explore the aesthetic results of medial upper Iip repair for skin and soft tissue defects using local flap.Methods According to the location and the size of upper lip defect,the modified rhomboid flap of 60 ° above the defect was designed to repair the wound in philtrum;the O-L flap along philtral column to vermilion border was designed to cover the wound close to the peak and lateral to philtral column.Results Twenty-one postoperative patients that underwent pigmented nevus removal (12 female,9 male;ages 16-33 years) had defects in philtrum for 10 cases and close to the peak and philtral column for 11 cases.The diameter of the defect ranged from 0.5 cm to 1.0 cm.All flaps survived primarily without any complications and follow-up was for 1 to 18 months with excellent outcomes in all cases.All patients were satisfied with contour and functions.No pigmented nevus recurrence occurred.Conclusions The flap designed according to the aesthetic principle could be used to repair medial upper lip defect of medium-sized,which not only obtains functional reconstruction,but also satisfies aesthetic results,with aesthetic subunits saved and scar concealed.

Adult ; Heart Atria ; Heart Neoplasms ; complications ; Humans ; Intracranial Aneurysm ; etiology ; Magnetic Resonance Imaging ; Male ; Myxoma ; complications

Objective： The current study was designed to investigate the polymorphisms of DNA repair gene XRCC1 in Chinese population and test the hypothesis which these genetic variations may have impact on the risk of esophageal squamous cell carcinoma(ESCC). Methods： A case control study of 222 ESCC patients and 433 control subjects (matched for age, sex) was conducted to investigate the role of two XRCC1 polymorphisms(XRCC1 26304 T and XRCC1 281152 A) in ESCC. Genotyping was performed using PCR based restriction fragment length polymorphism techniques. The adjusted odds ratio (OR) and 95％ confidence interval (CI) was calculated using multivariate logistic regression. Results： Genotype frequencies of the XRCC1 C26304T were 51.7％ (CC), 41.6％ (CT) and 6.7％ (TT) in control group. The frequency of TT allele in control group (6.7％ ) was significantly lower than that in case group (12.6％ ), with the adjusted OR for ESCC being 1.83 (95％ CI 1.03－ 3.24; P< 0.05). Furthermore, the risk of ESCC for XRCC1 26304 TT alleles appeared to be more pronounced among smokers (adjusted OR=3.1,95％ CI 1.3－ 7.2) compared to nonsmokers (adjusted OR=2.3, 95％ CI 1.0－ 5.4), and among smokers who smoked≥ 20 cigarettes/day (adjusted OR=6.4, 95％ CI 2.0－ 23.7) compared to those who smoked< 20 cigarettes/day (adjusted OR=1.0, 95％ CI 0.2－ 4.3). Genotype frequencies of the XRCC1 G28152A were 53.3％ (GG), 38.1％ (GA) and 8.6％ (AA) in control group, which were not significantly different from that in case group. Conclusion： These findings support the hypothesis which polymorphism in XRCC1 DNA repair gene contributes to the risk of developing ESCC.

OBJECTIVETo search for the best therapy for simple obesity.

METHODSEighty cases were randomly divided into 3 groups. The body acupuncture group were treated based on the syndrome of heat of stomach and intestine, syndrome of spleen deficiency and stagnation of dampness, and syndrome of spleen and kidney yang-deficiency; the auricular and body acupuncture group were treated by the syndrome treatment of body acupuncture combined with auricular point sticking; the observation group were treated by the combined auricular and body acupuncture treatment plus moving cupping on back-shu points. Body weight, BMI, body fatd, blood lipids and clinically main symptoms before and after treatment were investigated.

RESULTSThe total effective rate was 69.6% in the body acupuncture group, 76.0%. in the auricular and body acupuncture group, and 90.6% treated in the observation group, with significant differences in the therapeutic effect, clinically main symptoms, external indexes of obesity and kidney ang-blood lipid metabolism between the observation group and the body acupuncture group. The various indexes in the auricular and body acupuncture group were superior to those iwere tthe body acupuncture group, with no significant differences in most indexes.

CONCLUSIONAuricular and body acupuncture combined with moving cupping at back-shu points has obvious therapeutic effect on simple obesity and this is a better therapy for simple obesity.

Acupuncture Points ; Acupuncture Therapy ; methods ; Acupuncture, Ear ; methods ; Adult ; Cholesterol, LDL ; blood ; Female ; Humans ; Male ; Medicine, Chinese Traditional ; Obesity ; blood ; therapy

Objective:To determine whether ox-LDL (oxdized low-density lipoprotein) is highly deposited on the uremic vessel wall and its influence on the vascular remodeling. Methods: Segments of radial arteries were obtained from 21 uremic subjects during the operation of A-V fistula prior to hemodialysis. Segments of internal thoracic arteries of similar diameter were obtained from patients with benign chest tumors as control.The vascular lesions and ox-LDL, CD68,MCP-1, eNOS,ET-1, PCNA,FN on the vessel wall were determined by means of H-E stain and immunohistochemistry. Results： With H-E stain,atherosclerotic plaques were found in the radial arteries of 4 uremic patients. The middle layer of the arteries in uremic patients were obviously thickened, and the T/D　(thickness of the wall/external diameter) ratio was significantly higher than those in control group(P<0.01). ox-LDL,CD68,MCP-1, ET-1, PCNA,FN on the vessel wall in uremic patients were much higher than those in control group (P<0.01). Moreover, ox-LDL on the vessel wall was positively related to the expression of other above mentioned substances on the vessel wall (P<0.01). Whereas the expression of eNOS on the vessel wall was lower than control group (P<0.01),and was negatively related to ox-LDL on the vessel wall(P<0.01). Conclusion: ox-LDL is an important factor contributing to uremic vascular remodeling by increasing the migration,adhesion and infiltration of monocyte,the proliferation of vascular smooth muscle cell and dysfunction of endothelia.