Biomarkers ; Hepatitis B ; therapy ; virology ; Hepatitis B Surface Antigens ; Hepatitis B virus ; Humans

Child ; Cranial Nerve Injuries ; drug therapy ; etiology ; Diagnosis, Differential ; Female ; Glossopharyngeal Nerve ; pathology ; Humans ; Malaria, Cerebral ; complications ; diagnosis ; drug therapy ; Vagus Nerve ; pathology

ObjectiveTo investigate the relationship among social support,coping style and mental health on university librarians.Methods421 librarians were assessed with the symptom checklist 90 (SCL-90),social support rating scale (SSRS) and simplified coping style questionnaire (SCSQ) in 2005. ResultsSome factor of SCL-90 negatively correlated with utility percentage of social support(P<0.05), and positively correlated with passive coping style(P<0.05). Except utility percentage,the other three factors of social support showed significant difference among different academic titles (P<0.05), and it was significant different (P<0.05) on passive coping factor among them. The score of social support improved with ages except for utility percentage (P<0.05).On positive coping factor but not negative, there were significant difference among different age groups(P<0.05). ConclusionThe social support and coping style obviously correlate with the mental health of university librarians.

Membrane fusion is essential for all life activities of eukaryotes and the fusion process requires the interaction of different vesicular transporters,which are highly conserved in eukaryotes,to coordinate specifically and facilitate the fusion of different biofilms. Vesicle associated membrane protein 8(VAMP8)mainly locates in vesicular as well as lysosomal membranes,and plays a vital role in the fusion of many different biofilms. This paper focused on the molecular structure,transcriptional regulation,post-translational modification and biological function of VAMP8 as well as the research progress on its correlation with human diseases,so as to provide new ideas for the treatment of related diseases and the development of effective therapeutics targeting VAMP8.

Objective To investigate the clinical effect of sitagliptin combined with metformin in the treatment of sulfonylurea-deficient elderly patients with diabetes mellitus.Methods Sixty patients with diabetes mellitus were enrolled in our hospital from January 2013 to December 2016.The patients were divided into observation group(30 cases) and control group(30 cases) according to the random number method.The patients in the observation group were treated with sitagliptin and metformin.The patients in the control group were treated with gemcitabine, and the clinical treatment effect, fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, fasting C peptide and postprandial 2hC peptide Level of statistical comparison.Results The clinical effect of the observation group was significantly higher than that of the control group.Before and after treatment, the fasting blood glucose, 2h postprandial blood glucose, glycosylated hemoglobin, fasting C peptide and postprandial 2hC peptide level were not significantly different After fasting blood glucose, 2h postprandial blood glucose and glycosylated hemoglobin levels were significantly lower than before treatment, after treatment of fasting C peptide and postprandial 2hC peptide levels were significantly higher than before treatment.Conclusion The clinical efficacy of serotretine combined with metformin in the treatment of elderly patients with diabetes mellitus is similar to that of Yuxing, and the combination is more convenient and more suitable for clinical treatment.It is worthy to be popularized and applied in clinical practice.

Objective: Hitherto there has been no report on the changes of microvessels and the expression of angiogenic factors after photodynamic therapy(PDT) of liver carcinoma.The purpose of this study was to investigate the effect of PDT on the microvessels and the expression of vascular endothelial growth factors(VEGF) in tumor cells. Methods: The mice models subcutaneously transplanted with Heps liver carcinoma were randomly divided into a PDT group(n= 28) and a control group(n= 28).The dynamic changes of the microvessels and VEGF expression in the tumor cells were observed at 2,6,24 and 72 h after PDT by H-E and immunohistochemical staining.Results: Progressive changes were seen in the tumor microvessels at the four time points after PDT,including dilatation,blood stasis,hypostasis,hemorrhage,and angiolysis.Compared with the control group,the microvessel density of the tumors was reduced significantly(P

The incidence of swallowing disorder is high in previous research both in oral and pharyngeal stage, and there are many related factors contributing to the assessment of swallowing function. This article reviewed the research progress of dysphagia after traumatic brain injury (TBI) from epidemiology, assessment methods, characteristics, risk factors, therapeutic strategies and clinical outcome。

Adenoviruses, Human ; Child ; Humans ; Orthomyxoviridae ; Respiratory Syncytial Viruses ; Respiratory Tract Infections ; virology

Objective To study the risk factors for cognitive impaurment in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients with ischemic stroke.Methods Three hundred and twenty-eight OSAHS patients with ischemic stroke were divided into cognitive impairment group (n=158) and cognitive impairment-free group (n=170) according to their MMSE score.The risk factors for their cognitive impairment were analyzed by multivariate logistic regression analysis and stratification analysis respectively.Results The blood glucose and lipid,AHI,LSaO2,infarction size and site,HIF-1 and Ngb level were significantly different between the two groups (P＜0.01).Multivariate logistic regression analysis showed that blood glucose and lipid,AHI,infarction site and Ngb level were the independent risk factors for cognitive impairment (OR=3.527,95％CI:1.559-7.983,P=0.002;OR=6.413,95 ％CI:2.766-14.865,P=0.000;OR=4.099,95％CI:1.694-9.918,P=0.002;OR=4.484,95％CI:1.950-10.310,P=0.000;OR=3.891,95 ％CI:1.759-8.606,P=0.001).Stratification analysis showed that high HIF-1 and Ngb levels were positively related with cognitive impairment in patients with AHI＞20 times/h,frontotemporal infarction,hyperglycosemia or hypoglycosemia,and dyslipidemia.Conclusion High HIF-1 and Ngb levels are independently related with cognitive impairment in OSAHS patients with ischemic stroke.

AIM:To evaluate the economic effectiveness in different pharmacotherapeutic schemes for tuberculosis.METHO_DS:Using pharmacoeconomic cost-effect analysis,three chemotherapy schemes,A,B and C,for bacillary tuberculosis were compared.RESULTS:Among three schemes,C was the best one.CONCLUSION:The results show that pharmacoeconomics plays an important role in optimizing therapeutic scheme,guiding rational drug use and increasing economic effectiveness.