Vav3 oncogene is a member of the Vav family. Vav3 protein contains multiple functional motifs and is involved in cancer development and progression through its role in various cellular signaling processes, including cytoskeleton organization, calcium influx, genetic transcription, cell transformation, proliferation and apoptosis. In addition, Vav3 interacts with estrogen receptor and enhances ERα-mediated signaling axis, therefore plays an important role in breast cancer.

Adult ; Automobile Driving ; Female ; Hip Fractures ; etiology ; Humans ; Male ; Middle Aged ; Occupational Injuries ; complications ; Retrospective Studies ; Young Adult

Coronary Artery Bypass ; methods ; utilization ; Coronary Artery Disease ; pathology ; surgery ; Graft Survival

Objective:To analyze CT characteristics of pancreatic carcinoma coexisting with chronic pancreatitis versus chronic pancreatitis in order to improve its CT differential diagnostic accuracy.Methods:CT findings in 14 cases of pancreatic carcinoma coexisting with chronic pancreatitis and 15 cases of chronic pancreatitis were retrospectively analyzed.Both plain and enhanced CT scans were performed in all cases.Thin-layer scan was practiced when required.Observation was focused on the size,shape,density of pancreas,its relationship with Peripancreatic tissues,the images of enhancement,and the location,size,density of pancreatic carcinoma.Moreover,observation was focused on the dilation of common bile duct,main pancreatic duct and hepatic bile duct Then,CT characteristics of pancreatic carcinoma coexisting with chronic pancreatitis and chronic pancreatitis were analyzed and compared.Results:In the pancreatic carcinoma coexisting with chronic pancreatitis group,all cases have mass,and noenhancement in the arterial phrase.Peripancreatic blood vessels were invaded or surrounded(5 cases and 4 cases respectively).Peripancreatic adipose were not seen enough(5 cases).Lymph node enlargement(4 cases),Liver metastasis(5 cases).Dilation of common bile duc(t8 cases,9.67 mm?2.64 mm),6 of which showed broke off abruptly.Pancreas atrophy(6 cases),Calcification(4 cases),Dilation of main pancreatic duc(t7 cases),Pseudocys(t2 cases).In chronic pancreatitis group,pancreatic mass(2 cases),one of which showed no enhancement in the arterial phrase;Peripancreatic blood vessels was surrounded by Peripancreatic mass and the boundary between blood vessels and adipose was not clear(1 case);None of the cases was seen Peripancreatic blood vessels invasion;no liver metastasis or Lymph node metastasis.Dilation of common bile duc(t3 cases,7.53 mm?1.45 mm),one of which showed broke off abruptly.Pancreas atrophy(7 cases),Calcification(5 cases),Dilation of main pancreatic duct(7 cases,4.73 mm?3.04 mm),Pseudocyst(4 cases).Conclusion:Style of mass dynamic enhancement of pancreatic carcinoma coexisting with chronic pancreatitis,Peripancreatic blood vessels invasion,liver metastasis,and lymph node metastasis are important basis of CT differentiation of pancreatic carcinoma coexisting with chronic pancreatitis from chronic pancreatitis.

Objective To analyze the clinical behavior and correlative mechanism of the patients with the syndrome of neck injury associate with craniocerebral injury,to investigate its incidence for contributing to the diagnosis and therapy of the patients with the craniocerebral injury and improving the postoperative result. Methods Two hundred and eighty-three patients with craniocerebral injury treated from June 2000 to July 2003 were studied retrospectively. Results In 283 patients, 42( 14.8%) patients presented the syndrome of neck injury clearly in symptom or sign, of whom 39 ( 13.7% ) patients were diagnosed neck injury finally, 3 (1.1%) patients were clinically conclude neck injury. The syndrome mainly presents with noncerebral and nonaural vertigo incorresponding with the recovery of brain injury. Noncerebral, nonaural and nondigestive vomit. Intractable nuchal rigidity incorresponding with the recovery of brain injury. Motion and position limited, stubborn neck malaise, transient spinal cord injury. The symptoms were easy to be improved by neck motion control, neck traction,block therapy, massage and physiotherapy lamp. Conclusion The syndrome of brain-neck injury is a common injury. To learn the syndrome and take the regular therapy can improve the therapeutic efficacy of the craniocerebral injury.

ObjectiveTo explore the application of enlargement of plastic surgery for dural closure with radial neuro-patch in standardize large decompressive craniectomy (SLDC).MethodsTwenty-one patients (observation group) who needed a SLDC for various reasons were treated with radial incision in dura to release the high intracranial pressure and enlargement of plastic surgery for dural closure with radial neuropatch from March 2009 to June 2010.The neuro-patch were used as the dural substitutes.Twenty-one patients were treated with SLDC only for the similar reasons (control group).General healing effects were compared betweentwo groups.ResultsIn 6 hours and 72 hours after surgery,the rate of obvious effectiveness in observation group was significantly higher than that in control group [33.33％(7/21 ) vs.14.29％(3/21 ),33.33％(7/21 ) vs.19.05％(4/21 ) 、61.90％( 13/21 ) vs.28.57％(6/21 ),61.90％( 13/21 ) vs.38.10％(8/21 )](P ＜ 0.05).The rate of intracranial infection,cerebrospinal leak and epilepsy in observation group [0,0,4.76％ ( 1/21 )]was significantly lower than that in control group [14.29％ (3/21),14.29％ (3/21),19.05％ (4/21)](P ＜0.05).The rate of subcutaneous or subdural cerebrospinal fluid accumulation,cenencephalocele,cerebral ventricular malformation,brain hernia through the skull window had no significant difference between two groups [19.05％(4/21 ),0,4.76％( 1/21 ),0 in observation group;23.81％(5/21 ),9.52％(2/21 ),9.52％(2/21 ),4.76％( 1/21 ) in control group) (P ＞ 0.05 ).After followed up of 6-12 months,the rate of the well general outcome in observation group was significantly better than that in control group [85.71％ ( 18/21 ) vs.71.43％ ( 15/21 )](P ＜ 0.05 ).The rate of moderate-critical function handicapped in control group was significantly higher than that in observation group [23.81％(5/21 ) vs.9.52％(2/21 )](P＜0.05 ).ConclusionsThe SLDC is effective for decreasing the intracranial pressure,and the enlargement of plastic surgery for dural closure with radial neuro-patch can improve the efficiency and decrease the incidence of complicating diseases.This therapy can improve the patients' general quality of survival and is worth to be popularized in clinic.

Objective To observe the clinical outcomes of modified posteromedial and posterolateral approaches for the treatment of posterior tibial plateau fractures.Methods Between January 2006 and October 2011,25 patients with posterior tibial plateau fracture were identified.They were 17 men and 8 women,aged from 22 to 76 years (average,46.4 years).According to the AO/OTA classification,there were 4 cases of type 41-B1,6 cases of type 41-B2 and 15 cases of type 41-B3.According to Luo's three-column classification,they were all posterior column fractures.Ten patients with posterolateral tibial plateau fracture were treated by the modified posterolateral approach and the other 15 patients with posteromedial tibial plateau fracture by the modified posteromedial approach.The posterior fractures were fixated with a buttress plate.The knee function was evaluated at the last follow-up by the The Hospital for Special Surgery (HSS) Score.Results All the 25 cases were followed up for a mean time of 13.2 months (from 10 to 24 months).By the radiological Rasmussen criteria for fracture reduction,the mean score immediately after surgery was 16.5 points (from 13 to 18 points),with 20 excellent cases,4 good cases and one fair case.All patients were pain-free with full range of motion.Radiologically,bone union was achieved in all cases after a mean time of 13.9 weeks (from 12 to 18 weeks).No surgery-related complications were found.The mean HSS score was 91 points(range,74 to 97 points) and the good to excellent rate was 100％ (17 excellent and 8 good cases) at the last follow-up.The average range of knee motion ranged from 0° to 125°.Conclusion In the treatment of posterior tibial plateau fractures,because the modified posteromedial and posterolateral approaches can result in excellent fracture reduction under direct visualization and allow for posterior buttress plating,soft tissues can be well preserved and good functional results can be expected.

Child, Preschool ; Humans ; Leukocyte-Adhesion Deficiency Syndrome ; diagnosis ; therapy ; Male

Objective To explore the expression of caudal type homeobox transcription factor 2 (Cdx2) and liver intestinal cadherin (LI-CD) in intestinal metaplasia ( IM ) of gastric mucosa and gastric adenocarcinoma of the intestinal type (GAIT). Methods By using immunohistochemical method, the ex-pressions of Cdx2 and LI-CD were detected in biopsy sample including 30 cases of GAIT, 30 IM and 30 nor-mal controls. Results The positive rate of Cdx2 expression was 0, 93.3% and 46.7% in normal stomach mucosa, IM and GAIT, respectively. The positive rates of Cdx2 expression in IM and GAIT were significant-ly higher than that in normal stomach mucosa ( P < 0. 005 ), and the expression of Cdx2 in IM was signifi-cantly higher than that in GAIT (P<0. 005). Similarly, LI-CD was also negative in normal stomach muco-sa, and positive rates were 96. 7% and 73. 3% in IM and GAIT group, which were significantly higher than that in normal stomach mucasa (P < 0. 005 ), and LI-CD expression was also significantly higher in IM than in GAIT (P < 0. 05 ). In addition, the staining intensity of Cdx2 and LI-CD expressions in IM exhibited sig-nificant correlation (r=0. 827, P<0.01), but those in GAIT did not (r =0.438, P=0. 117). Conclu-sion Ectopic expression of Cdx2 and LI-CD can be found in IM and GAIT tissues, which could be an early marker in the disease progression. There is correlation between Cdx2 and LI-CD expression in IM tissue of human, and presumably, Cdx2 regulates LI-CD in IM development.

Apoptosis ; Child ; Heart Failure ; metabolism ; physiopathology ; Humans ; Signal Transduction ; Sympathetic Nervous System ; metabolism ; physiopathology ; Ventricular Remodeling