fluconazole.Conclusion: The susceptibilities of Malassezia species to ketoconazole,itraconazole,and fluconazole are different.Microdilution method from M27-A is suitable for testing the susceptibility of Malassezia in vitro.

Animals ; Hypothyroidism ; physiopathology ; Learning ; Memory ; Mice ; Motor Activity

Aged ; Female ; Humans ; Leukocyte Common Antigens ; metabolism ; Peroxidase ; metabolism ; Sarcoma, Myeloid ; metabolism ; pathology ; Vulva ; metabolism ; pathology ; Vulvar Neoplasms ; metabolism ; pathology

OBJECTIVE To investigate different kinds of cefoperazone and sulbactam sodium of different manutactures.METHODS RP-HPLC methods was used to determinate of the concerntrations of 4 categories cefoperazone and sulbactam sodium injections.Agar-dilution method was used to determinate the minimal inhibitory concentration(MIC) of 60 clinical bacterial strains.RESULTS Cefoperazone contents of sample 1 to 4 were 89.11%,100.49%,95.04% and 91.09% respectively;sulbactam contents 90.98%,75.93%,98.98% and 78.09% respectively.The number of the peaks of impurity were 5,4,4,5 respectively;and the total area of impurity peaks were 8.01%,2.94%,2.04% and 10.76%.MIC,MIC50,MIC90 of 4 samples have 2 to 3 difference grades.CONCLUSIONS The products of different manufacturs have different contents and impurities of cefoperazone and sulbactam sodium injections,and the MIC also has different results.In clinical experience,we should surveillance same kinds of antibiotics which produced by different manufacturer and try to reduce the side effect of antibiotics.

After the definition and emergence of MOOC and its development at home and abroad were described, the position of library under MOOC environment was discussed with stress laid on how to deepen the service in medical library by making use of MOOC and the challenges medical library is faced.

After the key technologies used in mobile reading service of library were compared , the authors pointed out that copyright and privacy protection were the major issues challenging the mobile reading service of library.Its development was prospected .

Drupal, a powerful content management system and content management framework, can provide a visiting interface for the mobile terminal equipments , especially the interface for the mobile APP program .How to imple-ment the information pushing function in mobile library using Drupal+PhoneGap was described by constructing the APP program model for information pushing and browsing in mobile library as an example.

After the meaning, features and application models of CDP technology were described, its application in protecting data in libraries was studied with Medical Library of Chinese PLA as an example, showing that CDP technology can effectively protect the data, improve their safety, and insure the stable operation of professional sys-tems in Medical Library of Chinese PLA.

Aim To study the relative bioequivalence of two domestic ciprofloxacin tablets. Methods Therandomized and crossover study was conducted in 18 healthy volunteers.After a single dose of the drugs,their plasma drug concentration was determined using HPLC.Results Both the two domestic ciprofloxacin tablets fit to one compartment model. The main pharmacokinetics parameters of the tested and reference ciprofloxacin were as followings: C_(max):(2.503?0.394) and (2.706?0.579) mg?L~(-1);T_(max):(1.343?0.402) and (1.075?0.379) h;T_(12):(4.174?1.201) and (3.826?1.005) h; AUC_(0-tn): (10.528?2.204) and (10.643?1.922) mg?L~(-1)?h;AUC_(0-∞): (11.409?2.139) and (11.558?2.160) mg?L~(-1)?h;F_(0-tn) and F_(0-∞) was (100.245?18.447)% and (100.470?20.108)%,respectirely. Conclusion The tested and reference formulations are bioeqivalent.

Objective:To study the role of RapIDYeast Plus (RYP) system in identifying common clinical yeasts.Methods: The target strains were cultured and passaged twice on Sabouraud dextrose agar,and were fed to RYP system after 24-48 h incubation at 30℃.Results: One hundred and thirty-nine of the 150 target strains were identified to the level of species correctly,and 8 undetermined strains were confirmed by additional tests.It was found that 3 strains had been incorrectly identified by RYP system.The accuracy of RYP system was calculated as 92% without additional tests and 98% with additional tests.Conclusion: RYP system is suitable for routine tests in clinical microbiological laboratory;it can accurately identify more than 40 kinds of yeasts and yeast-like bacteria in clinical practice.