Objective To analysis the etiology of intracranial and extracranial arteriovenous system impairment after pulmonary cancer.Methods A patient with pulmonary cancer with deep venous thrombosis, jugular venous thrombosis and cerebral infarction was analysed and reviewed combined with the literature. Results Pulmonary cancer could impair intracranial and extracranial arteriovenous system by hypercoagulability,anticoagulation system abnormalities and vascular wall damage, which could be manifested as cerebral infarction and deep venous thrombosis. Conclusion The hypercoagulable state secondary to pulmonary cancer is one of the main causes of intracranial and extracranial arteriovenous system thrombosis.

Objective To explore the correlation between metabolic syndrome (MS)and benign prostatic hyperplasia (BPH) and the drug treatment of BPH.Methods 300 cases of BPH patients treated between May 2011 to June 2012 in our hospital and Tong-Hai County hospitals of traditional Chinese medicine were included.The patients were divided into observing group (n=100) and control group (n=200).The observing group was treated with 5-alpha reductase inhibitors (finasteride).100 patients in control group-1 were treated with alpha-1 receptor blockers (terazosin).100 patients in control group-2 were treated with finasteride and terazosin.The changes of symptom scores,maximum urinary flow rate and prostate volume at month 3,month 6 and at end of a year after the treatment were compared among all groups.Results In 300 cases of BPH patients,there are 256 cases (85.3％) of MS+BPH,and 44 cases (14.7％) of simple BPH,with no statistically significant difference between the two groups in age and total cholesterol level (both P＞0.05).Among 256 cases of MS+ BPH,127 cases (49.6％) had diabetes,174cases (68.0％) had hypertension,85 cases (33.2 ％) had hypercholesterolemia or high triglyceride.The body mass index,blood pressure,fasting plasma glucose,IPSS gland volume were significantly higher (P＜0.05),and the maximum urinary flow rate was significantly lower in MS+BPH group than in the pure BPH group (P＜0.05).Prostate volume was positively correlated with age,body mass index,systolic blood pressure,fasting plasma glucose.IPSS score were positively correlated with age,body mass index,fasting blood glucose,total cholesterol.Maximum urinary flow rate were negatively correlated with age,fasting glucose,total cholesterol.At month 3 after treatment,the symptom score,maximum urinary flow rate were better in both of control group 1 and 2 than in the observation group (both P＜0.05).At 6 months after treatment,there was no statistically significant difference between the two groups in the symptom score,maximum urinary flow rate (both P＞0.05),while prostate volume was smaller in the observation group than in controls group 1 (P＜0.05).After a year of treatment,there were statistically significant differences in above indicators between the observe group and control group-1 (all P＜0.05),and had no statistically significant difference between the observe group and control group 2(all P＞0.05).Conclusions Most patients with BPH are suffering from MS at the same time.Body mass index,blood pressure,blood sugar,prostate volume,IPSS are higher in MS+BPH patients than in patients only with BPH.MS may affect the incidence and prognosis of BPH.Finasteride combined with terazosin can be used within 6 months,and finasteride can be used alone after 6 months of the drug therapy.

Objective To analyze the quality control of the conformal radiotherapy for nasopharyngeal carcinoma. Methods Using BJ-6 6MV linear accelerator, STAR -2000 3D TPS and immobilization device, the patient of nasopharyngeal carcinoma were treated by the conformal radiotherapy. Results Adopting individualized compatibly-shaped face masks and CT scanning (2mm interval, 2mm thickness), three dimensional data of the target and the other tissues were acquired. The conformal radiotherapy was designed in planning system. At the treatment, the target volume was put on the isocenter of the linear accelerator by the customized patient positioning. Conclusion Because the nasopharyngeal carcinoma is located in a special area and it is surrounded by some important organ, in the conformal radiotherapy, the quality control of the CT immobilization technique and the customized patient positioning is very important. This can ensure effective and safe irradiation for the small target volume while excessive irradiation is avoided in other surrounding organs.

Objective To study the rule of breaking Ferula fukanensis seed dormancy under low-temperature and content changes of endo-hormone.Methods The seeds were treated with stratification under 4 ℃ and germinated under 20 ℃.The content of endo-hormone,such as Z,GA_3,IAA,and ABA,was mensurated by HPLC.Results The seed germination rate achieved as high as 14% in 20 d and more than 60% in 40 d.Among breaking the seed dormancy,the content of endo-hormone was decreased gradually,while the rate of GA_3 and ABA was increased quickly in 10—20 d under 4 ℃ stratification.ConclusionThe stratification under 4 ℃ could break the seed dormancy.The rate of GA_3 and ABA is a pivotal factor of the seed dormancy.The endo-hormones IAA and Z have the significant effect on seed germination.

0.05),while we found significant difference in hospital duration between more than 60 days group and less than 30 days group(P

Objective To study the TPS dose distribution of the radiation therapy with wedge for upper-thoracic esophageal cancer.Methods Adopting spiral CT scanning,three dimensional data of the focus of infection and the other tissues were acquired.The radiotherapy plans with 45? wedges and without wedge were designed in TPS.The dose-volume histogram were calculated and compared.Results Although the average of dose of irradiated target was very close in the two plans,but there was remarkable difference in the dose uniformity.The Std(standard deviation) of dose in irradiated target was 6.31 in plan without wedge,and it was 4.45 in plan with the 45? wedge.The results show that the dose distri-butions of irradiated target are optimized by using the wedge.Conclusion It is a simple and effective method to use wedge for improving dose distribution in the radiation therapy for upper-thoracic esophageal cancer.

Objective:To compare the effects of Zn~(2+)onthe P2X receptor-mediated,ATP-induced currents in neurons separated from rat superior cervical ganglion(SCG),nodose ganglion(NG),and otic ganglion(OTG).Methods: Whole-cell patch clamp recording technique was used to study the regulatory effects of Zn~(2+) on ATP/??-me ATP-induced currents in the above 3 ganlglion neurons.Results: All SCG neurons responded to ATP with a sustained current,while no neurons responded to ??-me ATP;Zn~(2+) potentiated ATP-induced sustained currents to(1 442?34)% of the original value.All NG neurons responded to ATP and ??-me ATP with a similar sustained current;coapplication of Zn~(2+)(10 ?mol/L) potentiated their responses to(180?12)% and(262?28)%,respectively.All OTG neurons responded to both ATP and ??-me ATP with a sustained current.Coapplication of Zn~(2+)(10 ? mol/L) did not significantly potentiate the sustained currents induced by 10 ?mol/L ATP,but when ATP was at 30 ?mol/L,Zn~(2+)(10-100 ?mol/L) inhibited ATP-induced sustained currents in a dose dependent manner.If TNP-ATP(100 nmol/L) was first used to inhibit ATP-induced current to(26?2)% of the original value,Zn~(2+) at 10 ?mol/L potentiated the inhibited current to(127?9)% of its original value.Coapplication of Zn~(2+)(10 ?mol/L) potentiated ??-me ATP-induced currents to(146?5)% of the control.Zn~(2+)(300 ?mol/L) had no effect on ?_(on) and ?_(off) of ATP-and ??-me ATP-induced(30 ?mol/L) currents in OTG neurons.Conclusion:(1) Zn~(2+) is an allosteric modulator of P2X_(2) and P2X_(2/3) receptors in SCG and NG neurons and can potentiate the currents they induced.(2)The predominant receptor subtypes in OTG appear to be homomeric P2X_(2/3) and a little P2X_(2).Zn~(2+) has an inhibitory effect on the ATP-induced currents in OTG neurons,suggesting some novel members of the P2X purinoceptor exist in these neurons.

Objective: To observe the histomorphology/pathology changes and the expression of hypoxia inducible factor-1 alpha (HIF-1?) and vascular endothelial growth factor (VEGF) in drowning rats brain, in an attempt to explore new pathways for treatment of water drowning. Methods: The animal model of freshwater drowning was established with rats. The rats were randomly divided into the following groups: control group, drowning-to-death group and 2 min-drowning group (including 5 subgroups survived for 3, 6, 12, 24. and 40 hours after being drowned in water for 2 min [n=10]). Brain indices of rats in each group were detected and the pathological changes of cerebral tissues were observed; the expression of HIF-lo and VEGF were detected immunohistochemically and the correlation between them was analyzed. The dynamic blood oxygen saturation was detected in rats survived for 40 h after 2 min-drowning at different points. Results: Brain index of the drowning group and groups surviving for 24, 40 hours after drowning were obviously higher than that of the control group (P

Objective To evaluate the effect of controlled hypotension with nitroglycerin and esmolol in the operation of endoscopic nasal surgery.Methods 60 patients undergoing selective endoscopic nasal surgery were randomly divided into three groups averagely: control group (groupⅠ), controlled hypotension with nitroglycerin group(group Ⅱ), controlled hypotension with nitroglycerin and esmolol group (groupⅢ). Every group has 20 patients.Mean artery pressure (MAP), HR, scores of surgical field quality(SSFQ) were recorded before anaesthesia and 10,20,30,40 minutes after anaesthesia. After the operation, bleeding capacity, operation time and dosage of nitroglycerin were recorded too.Results The bleeding capacity and operation time in groupⅡ and Ⅲ was significantly less than that in groupⅠ(P

Objective To observe the effect of Ganshu Granule on different models of fatty liver in rats. Methods Rats with acute fatty liver induced by alcohol and carbon tetrachloride, rats with chronic fatty liver induced by alcohol and high-fat diet, and rats with acute fatty liver induced by ethionine were used, and the effects of different doses of Ganshu Granule on serum lipid metabolism, intrahepatic lipid metabolism and histopathological changes in liver were observed. Results In fatty liver rats induced by alcohol and carbon tetrachloride, Ganshu Granule could reduce the level of total cholesterol (TC), triglycerides (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in serum and could decrease total fat and glycogen(Gn) in liver obviously. In fatty liver rats induced by alcohol and high-fat diet, Ganshu Granule could significantly decrease the level of TC, TG, ALP, LDL and ALT in serum and could reduce the content of total fat, TG and Gn in liver obviously. In fatty liver rats induced by ethionine, Ganshu Granule could decrease the level of TC, TG and ALT in serum, raise the level of HDL in serum and could decrease the content of total fat, TG and Gn in liver obviously. The histopathologic results showed the degree of hepatic steatosis and hepatocellular necrosis were lessened in all of the treated groups. Conclusion Ganshu Granule is effective in preventing and treating fatty liver.