Objective To investigate the evaluation of serum cystatin C and treating efficacy of enalapril for contrast induced nephropathy after percutaneous coronary.intervention.Methods 86 patients who need coronary angiography or coronary stents implantation by skin were divided into observation group(43 cases)and control group(43 cases)randomly.The fasting venous blood was extracted and in which Cys-C and Scr were tested.All the patients were given water therapy,and enalapril was added in observation group.Diversification of concentration of Cys-C and Scr and efficacy of enalapril were recorded.Results There was no difference of Cys-C and Scr in serum and eGFR before and after operation(all P＞0.05),and the concentration of BUN was(3.96±0.89)mmol/L,which was lower after operation(P＜0.05),and the rate of CIN incidence was 2.33 ％(1 case).The concentration of Cys-C in serum was(18.4±0.58)mg/L,which was significantly higher than preoperation(P＜0.05),and there was no significant difference of Scr,eGFR and BUN before and after operation(P＞0.05),and the rate of CIN incidence was 11.63％(5 cases).Conclusion Cys-C was more sensitive in early detection for contrast induced nephropathy and more convenient.The rate of CIN incidence could be decreased by using enalapril.

This is a case report of a 7-year-old boy who presented with lower limb pain. He was initially presumed to have growing pains but was subsequently diagnosed with acute lymphoblastic leukaemia (ALL). This case highlights the important clinical presentations and differential diagnoses of ALL that a family physician should be cognizant about to avoid misdiagnosis. It also demonstrates the importance of understanding the patient and family's perspectives when evaluating a child with lower limb pain. This enables us to anticipate and meet their needs.

Objective:To find a better way to protect the security and interests of vulnerable groups by exploring the problem of protecting the vulnerable groups in drug clinical trial from the perspectives of ethics committees,organization and researchers.Methods:According to the relevant literature and the actual situation of the hospital,this paper analyzed the security issues of vulnerable groups comprehensively.Results:Only the ethics committees,organization and researchers work together,can it protect the security and interests of vulnerable groups to the greatest extents.Conclusion:Further research on the security of vulnerable groups not only promotes the development of human health,but also plays a decisive role in improving the protection of subjects in drug clinical trial.

Objective To investigate the significance of MMP-3 and IL-15 in the patients with ankylosing spondylitis (AS).Methods The serum levels of MMP-3,IL-15,TNF-? and CRP of 45 patients with AS and 31 healthy controls were tested by sandwich ELISA.The results between the 2 groups were compared each other.Results Significantly increased serum levels of MMP-3,TNF-? and CRP were found in AS patients as compared to those in healthy controls(P

The era of targeted molecular therapy for cancer has arrived. The mechanisms of targeted molecular drugs are different from those of chemotherapy drugs. The tumor response evaluation criteria that we currently use are the summary of experiences from evaluating the effect of chemotherapy drugs. Despite continuous improvement and standardization of the details, tumor response evalua-tion criteria, from the earliest WHO criteria to the improved RECIST and RECIST 1.1 criteria, are all based on measurement of tumor size, as chemotherapy drugs directly kill tumor cells. The aforementioned criteria are outlined in this review. However, targeted molecu-lar drugs mainly inhibit tumor cell proliferation. The effect of targeted molecular drugs on tumors is different from that of chemothera-py drugs. Thus, tumor response evaluation criteria suitable for targeted molecular drugs have been developed in recent years. This re-view introduces Choi criteria that use CT attenuation coefficient (Hounsfield unit [HU]) to describe tumor density. The criteria have measured indicators that include tumor size and tumor density. This review also introduces the following criteria derived from the Choi criteria for Modified Choi (mChoi) criteria size and attenuation CT (SACT), and morphology, attenuation, size, and structure (MASS).

Objective:To observe vox acoustics features of patients of lung Qi deficiency,understand the influence of different extents of lung Qi deficiency on phonation,and expound the relationship between lung Qi state and phonation. Methods:Apply computer vox analysis system to test the vox sustainable vowel signal(i) of 65 cases of lung Qi deficiency and 20 cases of healthy persons respectively,observe and analyse their acoustics parameters(basic frequency,micro bother of frequency,slight bother of swing and standard yawp energy) of natural sound lowest bourdon and comfort sound and natural sound most alt. Results:For lung Qi deficiency patients,the basic frequency of 3 different phonations is lower than healthy persons,whose lowering trend increases with degrees of lung Qi deficiency,among which,under lowest bourdon of natural sound,there's marked difference of basic frequency between middle and severe lung Qi deficiency and healthy adults(P

Objective To analyze the quality control of the conformal radiotherapy for nasopharyngeal carcinoma. Methods Using BJ-6 6MV linear accelerator, STAR -2000 3D TPS and immobilization device, the patient of nasopharyngeal carcinoma were treated by the conformal radiotherapy. Results Adopting individualized compatibly-shaped face masks and CT scanning (2mm interval, 2mm thickness), three dimensional data of the target and the other tissues were acquired. The conformal radiotherapy was designed in planning system. At the treatment, the target volume was put on the isocenter of the linear accelerator by the customized patient positioning. Conclusion Because the nasopharyngeal carcinoma is located in a special area and it is surrounded by some important organ, in the conformal radiotherapy, the quality control of the CT immobilization technique and the customized patient positioning is very important. This can ensure effective and safe irradiation for the small target volume while excessive irradiation is avoided in other surrounding organs.

Objective To investigate the diagnostic value of growth hormone(GH) stimulating test in dwarfism of children and related influencing factors .Methods Arginine and L‐dopa were applied to perform GH stimulating test in 642 children with dwarf‐ism .GH levels were detected at 30 ,60 ,90 ,120 ,150 ,180 min after stimulation .All children were divided into GH deficiency (GHD) group ,with peak value of GH less than 10 ng/mL ,and non‐GHD group ,with peak value of GH at least 10 ng/mL .Physical and la‐boratory data of the two groups were compared .Results The proportion of children with GHD and without GHD were 68 .69%and 31 .31% ,respectively ,and with statistical difference(χ2 =6 .19 ,P<0 .05) .The GH peak value ,with a delay ,mainly appeared at 30 and 150 min after stimulation ,accounting for 22 .42% and 34 .27% .Levels of age ,body height standard deviation ,body mass in‐dex ,alanine aminotransferase ,aspartate aminotransferase ,insulin growth factor‐1 and 25‐hydroxyl vitamin D were statistically dif‐ferent between the two groups(P<0 .05) .Conclusion Arginine and L‐dopa combined stimulating test could be used for the diagno‐sis of GHD in children with dwarfism .GH level might be correlated with various physical and laboratory parameters ,which should be considered for the diagnosis of GHD .

Objective To determine the change of maternal heart rate during the treatment with ritodrine for threatened premature labor. Methods110 cases of threatened premature labor were chosen. The ritodrine 100mg in 5% G. S 500mL was intravenously administered. The initial dosage was 6 drops/min, and the dose was increased until uterine contractions were inhibited. The treatment lasted for 40 to 48 hours after the uterine contractions were inhibited, then the oral tablets was recommended. If necessary, repeated treatment was given to some patients. The maternal heart rate was recorded in the whole process of treatment and was compared with the dosage administered. The labor time, fetal weight and Apgar′s score were also analyzed. Results The maternal basic heart rate was increased at first and then decreased. The increasing significantly increased( P ＜ 0.01 ) when the uterine contraction was inhibited. , but no difference showed among the groups of different gestational age( P＞0.05 ). The maternal heart rate was increased with the increasing of ritodrine( max. 140/min). labor time was significantly prolonged with the treatment of ritodrine( P＜0.01 ) ,while that of the idiopathic premature labor was prolonged most obviously ( P ＜ 0.05 ). Average fetal weight was (2.42 ± 0.49) kg, and the average Apgar′s score was≥8. Conclusion In the treatment of inhibiting uterine contractions,the increasing of maternal heart rate caused by ritodrine can be used as an indicator of therapeutic effect.

Objective To evaluate the prognostic value of the first documented rhythm in patients with in-hospital cardiac arrest.Methods The clinical data of 62 in-hospital cardiac arrest patients collected from May 2011 to April 2016 were reviewed.Multiple regression analysis was performed for determination of the factors relevant to ROSC.The patients were divided into defibrillative rhythm group [ventricular fibrillation (VF) /ventricular tachycardia (VT)] and non-defibrillative rhythm group [pulseless electrical activity (PEA) /asystole] according to the first documented rhythm after cardiac arrest.The differences in rate of restoration of spontaneous circulation,number of survival at hospital discharge and those discharged with favorable neurological outcome were compared between groups.Results Logistic regression analysis showed that non-defibrillative rhythm was related to low rate of ROSC.Rate of ROSC (x2 =6.90,P =0.01),number of survival at hospital discharge (x2 =10.49,P =0.00) and those discharged with favorable neurological outcome (x2 =14.70,P =0.00) were higher in the defibrillative rhythm group,while there was no difference in outcomes between the VF and VT groups.There was no difference in consequence found between the PEA and asystole groups.Conclusion Rate of restoration of spontaneous circulation,number of survival at hospital discharge and those discharged with favorable neurological consequence were higher with defibrillative initial rhythm.