Objectives To compare the difference of blood mass spectrometry analysis between decompensated liver cirrhosis patients and compensated liver cirrhosis patients. Methods Thirty-four patients with decompensated liver cirrhosis and 47 patients with compensated liver cirrhosis were selected. All patients were analyzed by blood mass spectrometry, and the detected 93 parameters included amino acids, acylcarnitines and some of their ratios. Results After multivariate analysis using the 93 parameters, the two groups could be differentiated clearly. There were 32 parameters that contributed to the separation, which included 4 ratios. Logistic analysis showed that alanine, tetradecanoyl diacylcarnitine, tetradecenoylcarnitine, proline and serine could be used to separate the two groups sufficiently. Receiver operating characteristic curve analysis indicated that the area under the curve generated using the 5 parameters could reach to 0.99. Except alanine, the other 4 metabolites were all increased in the decompensated patients. Conclusions Blood mass spectrometry analysis could be used to differentiate decompensated and non- decompensated cirrhosis patients. The significantly changed metabolites might provide valuable hint in pathological study of the disease.

OBJECTIVE:To provide reference for breaking the“dual-track”system of the pharmacist and perfecting pharmacist system in China. METHODS:By reviewing laws and regulations relating to the pharmacist in recent 21 years,the implementation and problems of pharmacist system was investigated. RESULTS & CONCLUSIONS:The imperfection and dissonance of pharma-cist management regulations and laws system result in long-term“dual-track”system of pharmacist authentication. There still are other problems such as low rate of pharmacist registration and unbalanced regional distribution;unbalance between national li-censed pharmacist examination and examination condition of health systems pharmacist;divergence and mismatching between phar-macy education pharmacist training;social value of pharmacists cannot be reflected adequately. It is suggested to formulate Regula-tions on the Licensed Pharmacists as soon as possible,establish uniform and standard qualification and title appraisal system for na-tional pharmaceutical professional and technical personnel,promote licensed pharmacist classification registration and examination system reform,strengthen pharmacy education and licensed pharmacist training system reform,guide licensed pharmacist allocation rationally and orderly by various measures and enhance the propaganda of licensed pharmacist and their work,so as to promote the mergence of national licensed pharmacists qualification system and health professional technical pharmacist competence system.

Objective:To explore the role of clinical pharmacists in the diagnosis and treatment of drug-induced diseases. Meth-ods:Clinical pharmacists analyzed the abnormal changes in the patients and looked for drug factors during the ward round with physi-cians. Results:Clinical pharmacists found drug-induced diseases and irrational drug use, and proposed the solutions accepted by phy-sicians. Conclusion:Clinical pharmacists should actively participate in the diagnosis and treatment of drug-induced diseases.

Objective To investigate the ideal methods for correction of lower eyelid retraction by lateral canthal anchoring.Methods The authors retrospectively reviewed the records of 126 patients(207 eyelids) operated on between June 1999 and 2005 by one senior surgeon.The age of the patients ranged from 28 to 72 years(mean,46 years).Transcanrhal canthopexy was used in 20 patients(33 eyes);The 3 mm tarsal strip procedure was used in 35 patients(57 eyes);Transcanrhal canthopexy combined with Hamra's lower blepharoplasty was used in 26 patients(45 eyes).The tarsal strip procedure combined with Hamra's procedure was used in 45 patients(72 eyes).75 patients(123 eyes) were followed up for 6～12 months.Mean follow-up time was 8 months. Results Of them,125 patients were uniformly satisfied with their cosmetic and functional outcome at last follow-up;one patient had undercorrection of retraction.There were no major complications and only one minor complications(corneal irritation from graft sutures),which resolved in the early follow-up period.Conclusions The lateral canthal anchoring is an effective,aesthetic,and functional treatment for moderate to severe lower eyelid retraction resulting from multiple causes.This procedure is associated with predictable results,a low morbidity rate,and high patient satisfaction.

fluconazole.Conclusion: The susceptibilities of Malassezia species to ketoconazole,itraconazole,and fluconazole are different.Microdilution method from M27-A is suitable for testing the susceptibility of Malassezia in vitro.

Objective: To compare the influences of onychomycosis on quality of life between patients from Luoyang and Shanghai. Methods: A semi-structured questionnaire was used to analyze and compare the influences of onychomycosis on the quality of life of patients from Luoyang and Shanghai. Results: Ninety-six patients with onycomycosis were from Luoyang district, including 41(42.7%) males and 55 (57.3%) females. One hundred and eighteen patients were from Shanghai, including 52 (44.1%) males and 66 (55.9%) females. Onychomycosis had more severe influences on patients living in Luoyang than those living in Shanghai from the following 4 perspectives: subjective health feeling, emotional influence, thinking influence, and social communication difficulties. Onychomycosis had greater influence on patients who aged 41-50 years old, who had a disease course of 1-5 years, and who had a higher academic background. Conclusion: The influences of onychomycosis on quality of life are different for patients with different economic, cultural backgrounds.

Coats disease is a relatively rare and idiopathic disorder characterized by retinal telangiectasia and massive intra-retinal and (or) sub-retinal lipid accumulation, resulting in complications including retinal detachment and neovascular glaucoma. Previous reports have revealed that Coats disease can be associated with other disorders, especially some inherited diseases, such as retinitis pigmentosa (RP) and facioscapulohumeral muscular dystrophy (FSHD). Coats disease associated with other inherited disorders is generally called Coats-like retinopathy, which has some unique features that differs from the classic Coats disease, for example there is no sex and age preference, more bilateral cases, more severe cases and more genetic factors involved. Patients of Coats-like retinopathy with RP and FSHD may have mutations in Crumbs homologue gene 1 and D4Z4 genes.

Objective To investigate the relative factors contributing to depression and anxiety in the patients with hyperthyroidism. Methods The degrees of depression and anxiety in 141 patients with hyperthyroidism and 163 non-hyperthyroid individuals were assessed using Carrol Drpession Scale and Self-rating Anxiety Scale. The collected data were then subject to t-test, ?~2 test and partial correlation analysis. Results The incidence of depression, anxiety and both in the patients with hyperthyroidism was 66.7%, 53.1% and 42.5%, respectively, and there was a significant positive correlation between depression and anxiety (r=0.636,P

Atrial Fibrillation ; surgery ; Catheter Ablation ; Humans

OBJECTIVE To explore the quality control of disposable medical supplies,strengthen the management of disposable medical supplies.METHODS The procurement,inspection,storage,issuance,use,recycling,destruction,etc of the disposable medical supplies and aset of scientific managment procedures were developed. RESULTS Strengthening the management of disposable medical supplies,the occurrence of nosocomial infection and was reduced prevented the random loss of disposable medical supplies waste,to ensure safe and effective clinical use.CONCLUSIONS Hospital infection control and prevention of medical safety management are an important guarantee for strengthening the supervision of disposable medical supplies,and enhance the awareness of hospital infection control and prevention,which can be regarded as a modal of disposable medical supplies.