Neoplastic stem cells (NSCs)are the source of tumor occurrence and development,and its special microenvironment is involved in tumor drug resistance,recurrence and metastasis by regulating NSCs or changing itself. Eradicating NSCs and interfering the special microenvironment may be the new therapeutic strategies for cancer.

The relationship between adjunctive drug (AD) and other drugs in a compound prescription and the actions of AD are very complex. From historical view, it showed the adjunctive action of AD was only be recognized with emphasis on its action as corrigent and effect on complications. In modern medicine, the actions of AD were reduced to 3 aspects: the assistant action, the restrained action and the corrigent action, with new contents added in each aspect on the basis of the ancient understanding. The authors hold that to master the various actions of AD and its relationship with other drugs in the prescription would be helpful in choosing them accurately and scientifically, thus to contribute the treatment in accordance with disease.
China ; Drug Combinations ; Drug Prescriptions ; Drug Synergism ; Drugs, Chinese Herbal ; administration & dosage ; History, 16th Century ; History, 17th Century ; Humans ; Medicine, Chinese Traditional ; history

Objective:The effect of the linseeds,VE and ethoxyquinoline in feed on the productive performance of the Hailanhong layers and ?-3 PUFA deposition in the yolk of laying eggs was studied. Method:Four hundred and eighty healthy layers of 48 weeks of age were randomly selected. The linseeds,VE and ethoxyquinoline of different levels in diet were fed on these layers. The indices of the productive performance and the fatty acids content of yolk were determined. The regression model of the fatty acids deposition was established. Results:The effect of the linseeds,VE and ethoxyquinoline in feed on the productive performance was slight. The most deposition of ?-3 PUFA was found by adding linseeds 15%,VE 0.17g/kg feed without ethoxyquinoline. Conclusion:The deposition of ?-3 PUFA in eggs could be regulated by controlling the proportion of linseeds and VE in feed with no effect on productive performance of layers.

Objective To study the innervation between baldder and rectum.Methods The retrograde fluorescent double labeling method was used.Propidium Iodide(PI)was injected into the right wall of the rectum of male SD rats and Bisbenzimide(Bb)into their right wall of urinary bladder.Results The fluorescent double labeled neurons were found in the right L6-S3 and L1-L3 dorsal root ganglia(DRG).Conclusion DRG cells at L6-S3 and L1-L3 simultaneously innervate the rectum and the urinary bladder,explaining that the abnormal micturition due to chronic constipation may be caused by axis reflex at the level of the peripheral process of DRG cells.

Esophagus ; pathology ; Female ; Foreign Bodies ; complications ; diagnostic imaging ; Humans ; Infant ; Radiography, Thoracic ; Tomography, X-Ray Computed ; Trachea ; pathology ; Tracheoesophageal Fistula ; diagnostic imaging ; etiology ; surgery

Adult ; Facial Hemiatrophy ; Humans ; Male

Aortic Valve ; pathology ; Calcinosis ; Heart Defects, Congenital ; pathology ; Heart Valve Diseases ; pathology ; Humans

The accessibility of orphan drugs has been the focus of many countries. Many countries and regions have established special laws and regulations to promote the development of orphan drugs since 1980’s. The development of orphan drugs has now become to be an important strategy for the drug development of many large pharmaceutical companies. At present, China has not yet defined the rare diseases, and the orphan drugs used in China are almost dependent on imports. The domestic situation that the research and development, introduction, production and sales of orphan drugs lack the policy support has been the bottleneck restricting the development of related industries in China. This paper reviews the present status of worldwide development of the rare diseases and their therapeutic drugs, and put forward related suggestions for the development of orphan drugs in China.

AIM:To investigate efficacy of ranibizumab combined with laser treatment for patients with branch retinal vein occlusion (BRVO) and macular edema.METHODS: We selected 67 patients (67 eyes) with BRVO and macular edema in our hospital from March 2013 to June 2016, they were randomly divided into observation group (n=31) and control group (n=36).The observation group was treated with ranibizumab combined with laser treatment.The control group was treated with macular grid photocoagulation.We observed best corrected visual acuity (BCVA), centre macular thickness (CMT) and macular leakage of two groups.RESULTS: The BCVA of observation group at 1, 2 and 3mo after treatment were 0.41±0.07, 0.42±0.05 and 0.48±0.05, significantly higher than those of the control group (P<0.05).The CMT of observation group at 1, 2 and 3mo after treatment were 203.11±59.13μm, 201.41±56.22μm and 204.22±60.13μm, significantly lower than those of the control group (P<0.05).The blood vessel leakage of observation group at 3mo after treatment was significantly better than that of the control group (P<0.05).No leakage ratio in the observation group was 71%.There were no postoperative infection, aseptic endophthalmitis and other complications in the two groups.CONCLUSION: Ranibizumab combined with laser treatment in patients with BRVO and macular edema has better curative effect, can improve the visual acuity of patients, eliminate macular edema, and is safe and reliable.

Medical microbiology is basic course of medicine.In order to improve teaching quality,we employ discussing-mode education in microbiology.This education style can not only enlighten and train poly-directional thought ability,capacity of bringing forth new ideas and pioneering spirit,but draw close the distance between students and modern life science,which make microbiological course become beginning of exploring microbiology.The employment of education style of discussing microbiology new advance is effective pathway of exploring most suitable high-quality person of talent training.