Biomarkers ; Hepatitis B ; therapy ; virology ; Hepatitis B Surface Antigens ; Hepatitis B virus ; Humans

Child ; Cranial Nerve Injuries ; drug therapy ; etiology ; Diagnosis, Differential ; Female ; Glossopharyngeal Nerve ; pathology ; Humans ; Malaria, Cerebral ; complications ; diagnosis ; drug therapy ; Vagus Nerve ; pathology

Membrane fusion is essential for all life activities of eukaryotes and the fusion process requires the interaction of different vesicular transporters,which are highly conserved in eukaryotes,to coordinate specifically and facilitate the fusion of different biofilms. Vesicle associated membrane protein 8(VAMP8)mainly locates in vesicular as well as lysosomal membranes,and plays a vital role in the fusion of many different biofilms. This paper focused on the molecular structure,transcriptional regulation,post-translational modification and biological function of VAMP8 as well as the research progress on its correlation with human diseases,so as to provide new ideas for the treatment of related diseases and the development of effective therapeutics targeting VAMP8.

ObjectiveTo investigate the relationship among social support,coping style and mental health on university librarians.Methods421 librarians were assessed with the symptom checklist 90 (SCL-90),social support rating scale (SSRS) and simplified coping style questionnaire (SCSQ) in 2005. ResultsSome factor of SCL-90 negatively correlated with utility percentage of social support(P<0.05), and positively correlated with passive coping style(P<0.05). Except utility percentage,the other three factors of social support showed significant difference among different academic titles (P<0.05), and it was significant different (P<0.05) on passive coping factor among them. The score of social support improved with ages except for utility percentage (P<0.05).On positive coping factor but not negative, there were significant difference among different age groups(P<0.05). ConclusionThe social support and coping style obviously correlate with the mental health of university librarians.

Objective To investigate the clinical effect of sitagliptin combined with metformin in the treatment of sulfonylurea-deficient elderly patients with diabetes mellitus.Methods Sixty patients with diabetes mellitus were enrolled in our hospital from January 2013 to December 2016.The patients were divided into observation group(30 cases) and control group(30 cases) according to the random number method.The patients in the observation group were treated with sitagliptin and metformin.The patients in the control group were treated with gemcitabine, and the clinical treatment effect, fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, fasting C peptide and postprandial 2hC peptide Level of statistical comparison.Results The clinical effect of the observation group was significantly higher than that of the control group.Before and after treatment, the fasting blood glucose, 2h postprandial blood glucose, glycosylated hemoglobin, fasting C peptide and postprandial 2hC peptide level were not significantly different After fasting blood glucose, 2h postprandial blood glucose and glycosylated hemoglobin levels were significantly lower than before treatment, after treatment of fasting C peptide and postprandial 2hC peptide levels were significantly higher than before treatment.Conclusion The clinical efficacy of serotretine combined with metformin in the treatment of elderly patients with diabetes mellitus is similar to that of Yuxing, and the combination is more convenient and more suitable for clinical treatment.It is worthy to be popularized and applied in clinical practice.

Objective: Hitherto there has been no report on the changes of microvessels and the expression of angiogenic factors after photodynamic therapy(PDT) of liver carcinoma.The purpose of this study was to investigate the effect of PDT on the microvessels and the expression of vascular endothelial growth factors(VEGF) in tumor cells. Methods: The mice models subcutaneously transplanted with Heps liver carcinoma were randomly divided into a PDT group(n= 28) and a control group(n= 28).The dynamic changes of the microvessels and VEGF expression in the tumor cells were observed at 2,6,24 and 72 h after PDT by H-E and immunohistochemical staining.Results: Progressive changes were seen in the tumor microvessels at the four time points after PDT,including dilatation,blood stasis,hypostasis,hemorrhage,and angiolysis.Compared with the control group,the microvessel density of the tumors was reduced significantly(P

The incidence of swallowing disorder is high in previous research both in oral and pharyngeal stage, and there are many related factors contributing to the assessment of swallowing function. This article reviewed the research progress of dysphagia after traumatic brain injury (TBI) from epidemiology, assessment methods, characteristics, risk factors, therapeutic strategies and clinical outcome。

BACKGROUND:Stent implantation is a common treatment for various cardiovascular diseases. Biodegradable AZ31 magnesium al oy stent is a new kind of biodegradable stent, but its degradation time and effect are stil rarely reported. OBJECTIVE:To investigate the degradation time and effect of AZ31 magnesium al oy stent in the rabbit aorta. METHODS:Twenty New Zealand white rabbits were subjected to implantation of biodegradable AZ31 magnesium al oy stents into the abdominal aorta. After implantation, the animals were grossly observed, and five animals were sacrificed under anesthesia at 1, 2, 3 and 4 months respectively for X-ray and histological observations. The number of residual struts was calculated under microscope. RESULTS AND CONCLUSION:X-ray findings showed that the implanted stent was found to be in complete form at 1 month after implantation, and its degradation was elicited at 2 months, indicating the stent lost its supporting role gradual y. The stent was degraded mostly at 3 months and degraded completely at 4 months. After implantation, the degradation rate of the stent was increased over time, which was confirmed by the X-ray findings. The number of residual struts was correlated with the time of degradation (r=-0.943, P<0.05). The slope of the linear regression equation was-0.12, based on which, the total time of the stent degradation was calculated to be 105 days. These results show that the AZ31 magnesium al oy stent implanted in the rabbit aorta is gradual y degraded with time, and the number of its residual struts exhibits an association with the degradation time. Given that the average number of degraded struts per day is 0.12, the complete stent is expected to be degraded within 105 days after implantation.

Objective To study the clinical effects of endovascular stent-graft repair for thoracic aortic aneurysm(TDA).Methods The clinical records of 32 patients with thoracic aorta dissecting aneurysm,including 26 men and 6 women,who underwent endovascular repair were retrospectively analyzed.The characteristics,location,and anatomic condition of dissecting aneurysm were evaluated using CTA before operation.Under general or local anesthesia,32patients underwent endovascular repair under dynamic DSA.For those patient,8 Talent,22 Yuhengjia(Beijing) and 2 Microinvasive(Shanghai) stent grafts were used.Results Among them 32 patients the distance between entry tear and left subclavian artery was

Objective To discuss the clinical value of modified laparoscopic lithotomy of common bile duct.Methods Clinical data of 78 patients over the age of 60 with gallstone and choledocholithiasis who underwent modified laparoscopic lithotomy of common bile duct in the past four years were analysed.Results All operations were successful.T-tubes were withdrawn 4 weeks after operation.Of the 78 cases,77 cases hat no complications and only one case had a small incision infection.All patients recovered without complications after with drawal of T-tube.Conclusions Modified laparoscopic lithotomy of common bile duct can allow incision and suture of common bile duct and placement of T-tube under direct vision,and achieves excellent therapeatic results in the treatment of common duct stones,especially in elderly patients who cannot tolerate a long period of pneumoperitoneum.