Objective To explore the clinical effect of Huazhuo Tongqing Yin in treating chronic atrophic gastritis(CAG)with internal accumulation of turbidity and poison.Methods A total of 159 patients with CAG were randomly divided into traditional Chinese medicine group,western medicine group and control group,and were given Huazhuo Tongqing Decoction,rabeprazole sodium enteric-coated tablets and morodan,respectively.Clinical efficacy,TCM syndromes,pathological changes,36-item Short-form Health Status Survey(SF-36)score and serum gastrin-17(G-17)and prostaglan-din E2(PGE2)before and after treatment were compared.Results The total effective rate was 92.45％in Chinese medicine group,62.26％in western medicine group and 66.04％in control group.After three months of treatment,the scores of epigastric pain,gastric distension and discom-fort,acid regurgitation and heartburn,belching,and stool stickiness in the three groups were all low-er than those before treatment,and the scores of epigastric pain,gastric distension and discomfort,acid regurgitation and heartburn,belching,and sticky stool in the traditional Chinese medicine group were lower than those in the control group andthe western medicine group(P＜0.05).The SF-36 scores of the three groups at 1-,2-,3-month improved after treatment,and the SF-36 score of the tra-ditional Chinese medicine group was higher than that of the control group and the western medicine group(P＜0.05).During follow-up,the SF-36 score of the traditional Chinese medicine group was still higher than those of the control group and the western medicine group(P＜0.05).After treatment,the serum levels of G-17 and PGE2 in the three groups were higher thanthose before treatment,and were higher in the traditional Chinese medicine group than those in the western medicine group and the control group(P＜0.05).No adverse reactions occurred in any of the three groups during treat-ment.Conclusion Huazhuo Tongqing Decoction can alleviate the symptoms of CAG,improve the pathological state and the quality of life.

Objective To explore the clinical effect of Huazhuo Tongqing Yin in treating chronic atrophic gastritis(CAG)with internal accumulation of turbidity and poison.Methods A total of 159 patients with CAG were randomly divided into traditional Chinese medicine group,western medicine group and control group,and were given Huazhuo Tongqing Decoction,rabeprazole sodium enteric-coated tablets and morodan,respectively.Clinical efficacy,TCM syndromes,pathological changes,36-item Short-form Health Status Survey(SF-36)score and serum gastrin-17(G-17)and prostaglan-din E2(PGE2)before and after treatment were compared.Results The total effective rate was 92.45％in Chinese medicine group,62.26％in western medicine group and 66.04％in control group.After three months of treatment,the scores of epigastric pain,gastric distension and discom-fort,acid regurgitation and heartburn,belching,and stool stickiness in the three groups were all low-er than those before treatment,and the scores of epigastric pain,gastric distension and discomfort,acid regurgitation and heartburn,belching,and sticky stool in the traditional Chinese medicine group were lower than those in the control group andthe western medicine group(P＜0.05).The SF-36 scores of the three groups at 1-,2-,3-month improved after treatment,and the SF-36 score of the tra-ditional Chinese medicine group was higher than that of the control group and the western medicine group(P＜0.05).During follow-up,the SF-36 score of the traditional Chinese medicine group was still higher than those of the control group and the western medicine group(P＜0.05).After treatment,the serum levels of G-17 and PGE2 in the three groups were higher thanthose before treatment,and were higher in the traditional Chinese medicine group than those in the western medicine group and the control group(P＜0.05).No adverse reactions occurred in any of the three groups during treat-ment.Conclusion Huazhuo Tongqing Decoction can alleviate the symptoms of CAG,improve the pathological state and the quality of life.

Objective:To analyze the research status of ground-level ozone pollution, explore research trends and hot spots, and provide references for future research on air pollution.Methods:Papers on ground-level ozone pollution research published before December 31, 2019 had been retrieved in SCI-E database of the "Web of Science Core Collection" in January 2020. The retrieval strategies were set as follows: TS= ( ("Tropospheric Ozone" OR "Low Level Ozone" OR "Ground Level Ozone") AND ("Air pollution*" OR "Air quality") ) . The survey included 2084 articles. By using bibliometric research and visual analysis tools, the research status of global ground-level ozone pollution was revealed from the aspects of time, discipline, journal, financing, institution, country and key words.Results:Cumulative publications increased in a cubic function of y=0.05 x3+0.80 x2+0.74 x+4.55 ( R2=0.999, P<0.01) . The most studied subject was Environmental sciences ecology (1401 articles, 67.23%) . Atmospheric Environment was the journal with the most articles (332 articles, 15.93%) . The United States was the country with the most publications (44.67%, 931/2084) , while China ranked second (17.13%, 357/2084) . 80.39% (287/357) of Chinese papers had funding information. Among the top 10 research institutions, 7 and 2 were affiliated to the United States and China respectively. Source apportionment and human health were high frequency keywords that had appeared in the last 5 years. Conclusion:The research on ground-level ozone pollution is in a good period of development. The United States has a leading position in this area, and China has a good prospect in this field. Pollution source apportionment and human health effects are new research directions.

Objective:To analyze the research status of ground-level ozone pollution, explore research trends and hot spots, and provide references for future research on air pollution.Methods:Papers on ground-level ozone pollution research published before December 31, 2019 had been retrieved in SCI-E database of the "Web of Science Core Collection" in January 2020. The retrieval strategies were set as follows: TS= ( ("Tropospheric Ozone" OR "Low Level Ozone" OR "Ground Level Ozone") AND ("Air pollution*" OR "Air quality") ) . The survey included 2084 articles. By using bibliometric research and visual analysis tools, the research status of global ground-level ozone pollution was revealed from the aspects of time, discipline, journal, financing, institution, country and key words.Results:Cumulative publications increased in a cubic function of y=0.05 x3+0.80 x2+0.74 x+4.55 ( R2=0.999, P<0.01) . The most studied subject was Environmental sciences ecology (1401 articles, 67.23%) . Atmospheric Environment was the journal with the most articles (332 articles, 15.93%) . The United States was the country with the most publications (44.67%, 931/2084) , while China ranked second (17.13%, 357/2084) . 80.39% (287/357) of Chinese papers had funding information. Among the top 10 research institutions, 7 and 2 were affiliated to the United States and China respectively. Source apportionment and human health were high frequency keywords that had appeared in the last 5 years. Conclusion:The research on ground-level ozone pollution is in a good period of development. The United States has a leading position in this area, and China has a good prospect in this field. Pollution source apportionment and human health effects are new research directions.

ObjectiveTo observe the modulatory effect of modified Zhenwutang on the interleukin-6 （IL-6）， matrix metallopeptidase-9（MMP-9）， type Ⅳ collagen（COL-Ⅳ） in rats with chronic renal failure （CRF） and to investigate the potential mechanism of its treatment of CRF. MethodFifty male SD rats were randomly divided into a modeling group of 40 rats and a normal group of 10 rats， and the modeling group was prepared by continuous adenine gavage for 12 weeks. After successful modelling， the modelling group was divided into the model group， the low dose （7.2 g·kg^-1·d^-1） group， the medium dose （14.4 g·kg^-1·d^-1） group， the high dose （28.8 g·kg^-1·d^-1） group and the Benadryl hydrochloride （10 mg·kg^-1·d^-1） group for gavage according to the random number table method， In the normal group and the model group， equal volume of distilled water was administered by gavage for 4 weeks. After the administration， the levels of blood creatinine （SCr）， blood urea nitrogen （BUN） and 24 h urine protein （24 h-UTP） were measured， the levels of serum IL-6 were measured by enzyme linked immunosorbent assay（ELISA）. Immunohistochemistry （IHC） was used to detect intercellular cell adhesion molecule-1 （ICAM-1）， IL-6， MMP-9， and other molecules in the rat kidney. The expression of ICAM-1 mRNA， IL-6 mRNA， MMP-9 mRNA and COL-Ⅳ mRNA in rat kidney tissues was measured by Real-time fluorescence quantitative polymerase chain reaction （Real-time PCR）. The expression levels of ICAM-1， IL-6， MMP-9 and COL-Ⅳ in rat kidney tissues were measured by Western blot. ResultCompared with the normal group， the levels of SCr， BUN and 24 h-UTP were significantly increased in the model group （P<0.01）； the serum IL-6 level was significantly increased （P<0.01）， the tubular lumen was dilated with atrophy， the tubular epithelial cells were necrotic， swollen and vacuolated， the interstitium was infiltrated by a large number of inflammatory cells and collagen fibers were deposited， the levels of IL-6， ICAM-1 and COL-Ⅳ were strongly positive in the tubular interstitium of the model group （P<0.01）， The levels of ICAM-1 mRNA， IL-6 mRNA and COL-Ⅳ mRNA were significantly increased （P<0.01） and MMP-9 mRNA was significantly decreased （P<0.05） in the model rats. ICAM-1， IL-6 and COL-Ⅳ protein expression was significantly increased （P<0.01） and MMP-9 protein expression was significantly increased （P<0.01） in the renal tissue， and MMP-9 protein expression was significantly decreased （P<0.01）. Compared with the model group， the 24 h-UTP， SCr and BUN levels of rats were significantly reduced after treatment with modified Zhenwutang （P<0.01）， the serum IL-6 level was significantly decreased （P<0.01）， the renal lesions of rats were significantly improved and collagen fiber deposition was reduced； the expression of IL-6， ICAM-1 and COL-Ⅳ in renal tubules and interstitium was weakened， and MMP-9 in ICAM-1 mRNA， IL-6 mRNA and COL-Ⅳ mRNA levels were significantly reduced （P<0.01） and MMP-9 mRNA levels were significantly increased （P<0.05）， ICAM-1， IL-6 and COL-Ⅳ protein expression was significantly reduced （P<0.01） and MMP-9 protein expression was significantly The expression of ICAM-1， IL-6 and COL-Ⅳ proteins was significantly decreased （P<0.01） and MMP-9 protein expression was significantly increased （P<0.01）. ConclusionModified Zhenwutang may regulate the IL-6/MMP-9/COL-Ⅳ signaling pathway， thereby reducing proteinuria， improving renal function， reducing renal pathological damage and delaying the progression of CRF interstitial fibrosis.