Objective To compare the clinical effects and safety of two kinds of adjuvant chemotherapy in treatment of patients with colon cancer with Ⅱ-Ⅲ stage after radical resection including 5 -FU/CF scheme and FOLFOX4 scheme.Methods 110 patients with colon cancer with Ⅱ-Ⅲ stage after radical resection were chosen from July 2010 to July 2013 in our hospital and were randomly divided into two groups.A group (55 patients) was given 5-FU/CF scheme and B group (55 patients) received FOLFOX4 scheme.The recurrence and metastasis rate with follow-up,survival time and drug side effects incidence were compared between the two groups.Results The recurrence and metastasis rates with follow-up of B group(18.18%,25.45%) were significantly better than A group (34.55%,63.64%)(χ2 =9.12,8.74,all P<0.05).The median survival time of B group (31.4 months) was sig-nificantly longer than A group(20.7months)(HR=1.83,95%CI:1.16-3.74,all P<0.05).The incidence rates of nausea and vomiting,loss of appetite,hair loss and anemia of A group were 83.64%,61.82%,60.00%,18.18%;which of B group were 89.09%,69.09%,63.64%,23.64%;there were no significant differences in incidence rates of drug side effects between the two groups (χ2 =1.72,2.54,1.04,2.47,all P>0.05).Conclusion Compared with 5-FU/CF scheme,FOLFOX4 scheme in treatment of patients with colon cancer withⅡ-Ⅲstage after radical resection can efficiently reduce the risk of recurrence and metastasis,prolong the survival time and not increase the risk and extent of drug adverse effects.