Objective To explore the effect of treadmill training on expression of glial fibrillary acidic protein (GFAP) and brain-derived neurotrophic factor (BDNF) after cerebral ischemia-reperfusion in rats. Methods 30 male Wistar rats were randomly divided into sham group, model group and treadmill training group, with 10 rats in each group. The latter 2 groups were modeled with middle cerebral artery occlusion for 2 hours and reperfusion. The treadmill training group underwent treadmill exercise on the 3rd day after modeling for 12 days. Neurological function was evaluated with modified Neurological Severity Scores (mNSS). The neuronal pathological change in ischemic cortex was observed with HE staining. The expressions of GFAP and BDNF in cortex were determined by Western blotting. Results Com-pared with the model group, the mNSS scores decreased in the treadmill training group (F=9.931, P<0.01), the pathological damage in the ischemia cortex significantly lessened, and the expressions of GFAP (t=6.73) and BDNF (t=3.78) increased (P<0.05). Conclusion Treadmill training may increase the expression of GFAP and BDNF after cerebral ischemia-reperfusion in rats, and promote the recovery of neurologi-cal function.

Objective:To explore the relationship between the latent classes of online emotion regulation among college students and the distribution difference of different types on variables such as gender,grade,ages of surfing the net and so on.Methods:Totally 421 college students were assessed with Online Emotion Regulation Questionnaire (OERQ).Latent class analysis was used to identify online emotion regulation classes,and then analyzed the distribution of latent classes among different genders,grades and ages of surfing the net.Results:Two latent classes of online emotion regulation were identified,including online emotion inhibiting/ignoring class (37.6％) and online emotion venting class (62.4％).The prevalence of online emotion venting class among girls (56.6％ vs.3.8％),sophomores (36.3％ vs.11.9％),juniors (23.4％ vs.3.1％),those with more than 36 months of surfing the net (31.6％ vs.18.8％) were significantly higher than the other of the respective kind.Whereas,the rate of inhibiting/ignoring class among boys (32％ vs.7.6％),freshmen (20％ vs.5％) were significantly higher.Conclusion:It suggests that online emotion regulation could be divided into two different latent classes and prevalence of each class is significantly different in different genders,grades,and ages of surfing the net.

Objective To investigate the clinical efficacy of acupuncture in treating subhealth.Methods One hundred and fifty-four patients with subhealth were allocated, using a random number table, to observation and control groups, 77 cases each. The control group received basic treatment by diet, exercise, rest and rest and psychological intervention and the observation group, acupuncture therapy in addition. Subhealth scale subscores and the 36-Item Short-Form Health Survey (SF-36) subscore were recorded and blood biochemical indicators were measured in the two groups before and after treatment. the clinical therapeutic effects were compared between the two groups.Results The total efficacy rate was 96.1% in the observation group and 83.1% in the control group; there was a statistically significant difference between the two groups (P<0.05). There were statistically significant pre-/post-treatment differences in subhealth scale subscores in the two groups (P<0.05). After treatment, sleep, digestion, urination, positive emotion, ability and social relation subscores were higher, and fatigue, discomfort and negative emotion subscores were lower in the observation group than in the control group (both P<0.05). There were statistically significant pre-/post-treatment differences in blood biochemical indicators in the two groups (P<0.05). After treatment, blood uric acid (UA), total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) were significantly lower and high-density lipoprotein cholesterol (HDL-C) was significantly higher in the observation group than in the control group (both P<0.05). The 36-Item Short-Form Health Survey (SF-36) subscore were higher in thetwo groups after treatment than before treatment (P<0.05). After treatment, physiological function, role-physical, role-emotional, body pain and general health subscore were significantly higher in the observation group than in the control group (P<0.05).Conclusions Acupuncture helps to improve subhealth status in population, regulate blood biochemical indicators and enhance the clinical therapeutic effect to raise the quality of life in the patients.

Objective:To explore the correlation between fibrinogen levels and chemotherapy effect of platinum drugs in ovarian cancer patients. Methods:Totally 91 ovarian cancer patients and 95 patients with benign ovarian tumor were involved in our retrospec-tive study, and the associations between preoperative fibrinogen levels and clinic pathologic parameters in the patients were analyzed. Results:High fibrinogen levels were observed in 36.26％ (33/91) of the patients with ovarian cancer ( >4.0 g·L-1), which was significantly higher than that in the patients with benign tumor(P<0. 05). The high fibrinogen levels in ovarian cancer patients were associated with the higher FIGO stage and poor chemo-response, while were not associated with the patients' age, CA-125 levels and histological type and grade (P>0. 05). More importantly, no correlation was observed between high blood fibrinogen and CA-125 lev-els (P>0.05). Chemotherapy resistance was more in the patients with high fibrinogen levels than that in the other patients(P <0. 05). The OR value of high fibrinogen levels was 3. 571, 95％ CI was 1. 276-10. 000, which suggested high fibrinogen level is a dangerous factor for chemotherapy resistance. Conclusion:The study suggested that elevated fibrinogen level was a dangerous factor for chemotherapy response, which has a potential role in the poor prognosis of ovarian cancer patients independent of CA-125.

Ubiquitous library and ubiquitous service are the future trend of library.Described in this paper are thus the extended traditional service and multidimensional personal and deepened information service such as sub-ject service, academic conference information service, special subject navigation service, new foreign book transla-tion service, special subject information service, in order to let the readers use the library at any time and at any place and enjoy the library everywhere .

Objective:To investigate the clinical effects of dezocine combined with flurbiprofen anesthesia for thoracotomy patients and the influence on postoperative irritability status. Methods:Totally 98 cases of patients with thoracotomy were selected and randomly divided into the control group and the research group with 49 ones in each. The control group was given fentanyl and dezocine patient-controlled intravenous analgesia at the end of surgery, and the research group was given dezocine combined with flurbiprofen instead. The clinical anesthesia effects and postoperative irritability status of the two groups were observed and statistically analyzed. Results:The VAS scores in 2 h and 4 h after the surgery in the research group were significantly lower than those in the control group ( P<0. 05). The Ramsay sedation scores at the extubation and in 5min after the extubation in the research group were significantly better than those in the control group (P<0. 05). Furthermore, the postoperative irritability rate and the probability of adverse reactions were significantly lower in the research group (P<0. 01). Conclusion:The implementation of dezocine combined with flurbiprofen anesthe-sia for thoracotomy patients can fully ensure analgesic effect and relieve postoperative restlessness with good clinical application value.

The value of big data for the clinical diagnosis and treatment of diseases in traditional Chinese medicine was studied according to the concepts, characteristics and techniques of big data, the opportunity and challenge for the information and innovation of traditional Chinese medicine in the era of big data were analyzed with certain measures were put forward for promoting the advances in traditional Chinese medicine .

Internet technology has influenced profoundly social relationships including doctor-patient rela-tionships in China.This paper argues that internet technology helps the patients play more important roles in medical decisions,offers more platforms and time for doctors to communicate with their patients,and promotes the improve-ment of health care quality and patients'satisfaction.Finally,the author affords some suggestions on how to deal with the internet technology challenges to doctor-patient relations in China.

Food allergy ( FA ) often leads to protracted diarrhea and chronic diarrhea, which influence children′s nutrition and growth seriously and early diagnosis and treatment is particularly important. Its pathogenesis includes IgE mediated,not IgE mediated,and mix. Mainly manifestations include:food protein mediated rectum colitis, food proteins mediated enterocolitis syndrome,food proteins mediated bowel disease,and coeliac disease ( CD) . Diagnosis should be asked for details of the history. Diet avoidance and open food challenge tests help determine the diagnosis. Treatment mainly for suspicious foods to avoid,breastfeeding should be continue,mothers need to avoid food allergies, artificial feeding should be changed to extensively hydrolysed protein formula( eHF) or amino acid-based formula( AAF) feeding. Try not to use of antibiotics,and to give support therapy. Early diagnosis and treatment,correct nutritional gui-dance can prevent serious complications,reduce its incidence.

Children short stature is pediatric endocrine disease.It has now been confirmed that short stature homeobox gene(SHOX gene)deletion and mutation are the molecular genetic basis of children Leri-Weill syndrome,Turner syndrome,idiopathic short stature and other short stature phenotype.SHOX gene defect has obvious heterogeneity in clinical phenotype.Early detection of SHOX gene defects provides important reference value and guiding significance for short stature diagnosis and treatment.