1.Correlation between Preoperative Plasma Fibrinogen Level and Chemotherapy Effect in Ovarian Cancer Patients
China Pharmacist 2017;20(9):1593-1595
Objective:To explore the correlation between fibrinogen levels and chemotherapy effect of platinum drugs in ovarian cancer patients. Methods:Totally 91 ovarian cancer patients and 95 patients with benign ovarian tumor were involved in our retrospec-tive study, and the associations between preoperative fibrinogen levels and clinic pathologic parameters in the patients were analyzed. Results:High fibrinogen levels were observed in 36.26% (33/91) of the patients with ovarian cancer ( >4.0 g·L-1), which was significantly higher than that in the patients with benign tumor(P<0. 05). The high fibrinogen levels in ovarian cancer patients were associated with the higher FIGO stage and poor chemo-response, while were not associated with the patients' age, CA-125 levels and histological type and grade (P>0. 05). More importantly, no correlation was observed between high blood fibrinogen and CA-125 lev-els (P>0.05). Chemotherapy resistance was more in the patients with high fibrinogen levels than that in the other patients(P <0. 05). The OR value of high fibrinogen levels was 3. 571, 95% CI was 1. 276-10. 000, which suggested high fibrinogen level is a dangerous factor for chemotherapy resistance. Conclusion:The study suggested that elevated fibrinogen level was a dangerous factor for chemotherapy response, which has a potential role in the poor prognosis of ovarian cancer patients independent of CA-125.
2.Application of latent class analysis in online emotion regulation in college students
Chinese Mental Health Journal 2017;31(3):252-256
Objective:To explore the relationship between the latent classes of online emotion regulation among college students and the distribution difference of different types on variables such as gender,grade,ages of surfing the net and so on.Methods:Totally 421 college students were assessed with Online Emotion Regulation Questionnaire (OERQ).Latent class analysis was used to identify online emotion regulation classes,and then analyzed the distribution of latent classes among different genders,grades and ages of surfing the net.Results:Two latent classes of online emotion regulation were identified,including online emotion inhibiting/ignoring class (37.6%) and online emotion venting class (62.4%).The prevalence of online emotion venting class among girls (56.6% vs.3.8%),sophomores (36.3% vs.11.9%),juniors (23.4% vs.3.1%),those with more than 36 months of surfing the net (31.6% vs.18.8%) were significantly higher than the other of the respective kind.Whereas,the rate of inhibiting/ignoring class among boys (32% vs.7.6%),freshmen (20% vs.5%) were significantly higher.Conclusion:It suggests that online emotion regulation could be divided into two different latent classes and prevalence of each class is significantly different in different genders,grades,and ages of surfing the net.
3.Observations on the Therapeutic Effect of Acupuncture on Biased Constitution-based Subhealth
Shanghai Journal of Acupuncture and Moxibustion 2017;36(5):550-554
Objective To investigate the clinical efficacy of acupuncture in treating subhealth.Methods One hundred and fifty-four patients with subhealth were allocated, using a random number table, to observation and control groups, 77 cases each. The control group received basic treatment by diet, exercise, rest and rest and psychological intervention and the observation group, acupuncture therapy in addition. Subhealth scale subscores and the 36-Item Short-Form Health Survey (SF-36) subscore were recorded and blood biochemical indicators were measured in the two groups before and after treatment. the clinical therapeutic effects were compared between the two groups.Results The total efficacy rate was 96.1% in the observation group and 83.1% in the control group; there was a statistically significant difference between the two groups (P<0.05). There were statistically significant pre-/post-treatment differences in subhealth scale subscores in the two groups (P<0.05). After treatment, sleep, digestion, urination, positive emotion, ability and social relation subscores were higher, and fatigue, discomfort and negative emotion subscores were lower in the observation group than in the control group (both P<0.05). There were statistically significant pre-/post-treatment differences in blood biochemical indicators in the two groups (P<0.05). After treatment, blood uric acid (UA), total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) were significantly lower and high-density lipoprotein cholesterol (HDL-C) was significantly higher in the observation group than in the control group (both P<0.05). The 36-Item Short-Form Health Survey (SF-36) subscore were higher in thetwo groups after treatment than before treatment (P<0.05). After treatment, physiological function, role-physical, role-emotional, body pain and general health subscore were significantly higher in the observation group than in the control group (P<0.05).Conclusions Acupuncture helps to improve subhealth status in population, regulate blood biochemical indicators and enhance the clinical therapeutic effect to raise the quality of life in the patients.
4.Effects of Treadmill Training on Expression of Glial Fibrillary Acidic Protein and Brain-derived Neurotrophic Factor in Rats with Cerebral Ischemia-reperfusion
Chinese Journal of Rehabilitation Theory and Practice 2016;22(2):132-135
Objective To explore the effect of treadmill training on expression of glial fibrillary acidic protein (GFAP) and brain-derived neurotrophic factor (BDNF) after cerebral ischemia-reperfusion in rats. Methods 30 male Wistar rats were randomly divided into sham group, model group and treadmill training group, with 10 rats in each group. The latter 2 groups were modeled with middle cerebral artery occlusion for 2 hours and reperfusion. The treadmill training group underwent treadmill exercise on the 3rd day after modeling for 12 days. Neurological function was evaluated with modified Neurological Severity Scores (mNSS). The neuronal pathological change in ischemic cortex was observed with HE staining. The expressions of GFAP and BDNF in cortex were determined by Western blotting. Results Com-pared with the model group, the mNSS scores decreased in the treadmill training group (F=9.931, P<0.01), the pathological damage in the ischemia cortex significantly lessened, and the expressions of GFAP (t=6.73) and BDNF (t=3.78) increased (P<0.05). Conclusion Treadmill training may increase the expression of GFAP and BDNF after cerebral ischemia-reperfusion in rats, and promote the recovery of neurologi-cal function.
5.Scientific issues and strategies for pathogenic diagnosis of corneal infection in China
Ophthalmology in China 1993;0(03):-
Corneal infection is the leading cause of corneal blindness in China.Timely diagnosis and reasonable treatment of infections in the cornea are based on accurate identification of corneal pathogens.With improved realization and technical development,pathogenic diagnostic techniques for infectious corneal disease have improved.However,many scientific issues remain to be challenging.In this article,the scientific issues and constructive strategies are presented for pathogenic diagnosis of corneal infection in China.
6.Characteristics of occupational exposure to bloodborne pathogens during operation
Chinese Journal of Infection Control 2017;16(7):666-668
Objective To analyze the characteristics of occupational exposure to bloodborne pathogens during op-eration,and provide reference for making the prevention and control measures.Methods Occupational exposure to bloodborne pathogens during operation in a tertiary first class hospital between June 2016 and January 2017 were surveyed,the survey included general information about health care workers(HCWs),modes of occupational expo-sure,exposure sources,types of sharp injuries,manipulation and so on.Results A total of 100 HCWs sustained occupational exposure to bloodborne pathogens during the operation,64(64.00%)were nurses,followed by doctors (n=30,30.00%).The main mode of exposure were sharp injuries(n=88,88.00%)and ocular mucosa exposure (n=10,10.00%).The main diseases of exposure source were hepatitis B(n=36,36.00%)and syphilis(n=11, 11.00%).The main sharp device that caused sharp injuries was transfusion system needle(n=31,35.23%),fol-lowed by syringe needle (n=24,27.27%)and suture needle(n=14,15.91%).The main manipulation resulting of sharp injury was intraoperative manipulation (n=31,35.23%).Conclusion Training about occupational exposure should be strengthened among HCWs,it is necessary to improve the record and report process of occupational expo-sure,strictly require HCWs,especially nurses in accordance with the standard operating procedure during the oper-ation process,so as to reduce the occurrence of occupational exposure to bloodborne pathogen during operation.
7.The Importance and Training of Language Learning Strategies in Medical Colleges
Chinese Journal of Medical Education Research 2006;0(08):-
Language learning strategy is one of the most important items in current college English syllabus,yet it hasn't been given enough attention to.Due to the features of medicine,it is of great importance and emergency to carry out language learning strategy training in medical colleges.The aim of this essay is to promote a new English teaching mode of strategy-based instruction.
8.Cultivation of oral communication competence in English teaching in universities
Chinese Journal of Medical Education Research 2006;0(08):-
Cultivating stuedents’Englsih oral communication competence is one of the goals and tasks of college English teaching.Therefore teachers should create the student-centered communication settings to strengthen the students’training in spoken English both in and after class to enhance the students’spoken English and communication competence.
9.On the Teaching Features and Management Models for Foreign Teachers
Chinese Journal of Medical Education Research 2003;0(02):-
Recently,more and more foreign teachers have come to teach in China.They have contributed a lot in English teaching,cultural communication,improving mutual understanding and friendship.This article summarizes the experience of being with the foreign teachers and also gives some advice in several aspects,so as to achieve a better exertion of their intelligence and functions.
10.Construction of a quality evaluation system for medical continuous education
Chinese Journal of Medical Education Research 2006;0(09):-
The Delphi technique was used in the study. Through consulting the panel experts, indicators and their weights were achieved accordingly. Altogether, thirty experts were invited to reply to two rounds of questionnaires. Evaluating system of the medical continuous education was set up.