Objective To compare color doppler ultrasound examination for the different pathological types of thyroid cancer.Methods 62 cases of thyroid cancer in patients with color doppler ultrasound examination,then compared with pathological examination and compared the different pathological types of thyroid cancer with ultrasound image map features.Results Ultrasound examination showed papillary adenocarcinoma in 31 cases within the hypoechoic,ill-defined in 28 cases,there was calcification in 31 cases,follicular carcinoma in 6 cases、6 cases and 12 cases,there were significant differences between the two groups ( x2 =27.884,20.545,13.964,P =0.000 ),There was no significant difference both in the form of regularity,the nature of the back echo,Vmax and RI.( P =0.427,0.338,0.110,0.872 ).Pathology consistent with papillary carcinoma was 80.0％,follicular carcinoma pathology found was 70.4％.Conclusion Color doppler ultrasound examination of the different pathological types of thyroid cancer had a certain differential diagnosis and it had higher rate of pathological diagnosis.

Objective To investigate the early enteral nutrition (EN) and total parenteral nutrition (TPN) on the periopera‐tive nutritional status of gastric cancer patients underwent total gastrectomy .Methods 96 cases of total gastrectomy for gastric cancer patients treated in our hospital from January 2011 to March 2013 were randomly assigned ratio EN group and the TPN group ,with 48 cases in each group;nutritional status were compared before and after treatment .Results EN group was superior in nutritional status than TPN group ,it had shorter recover time and less complications (P<0 .05) .Conclusion Early enteral nutri‐tion support can quickly restore the nutritional status of patients and improve the immune status .

OBJECTIVE To study the distribution and drug-resistance status of pathogens in surgically infective specimen in Renmin Hospital of Qichun County and provide the reference for clinically reasonable use of antibiotics.METHODS The infective specimen were collected to perform bacterial culture.The routine methods were adopted to identify pathogenic bacterium.Susceptibility testing was performed by K-B method.RESULTS Among 322 strains from surgically infective specimen,Staphylococcus aureus,Escherichia coli and Pseudomonas aeruginosa,ranking the top three,accounted for 25.2%,15.8% and 13.0%,respectively.The detection rate of meticillin-resistant S.aureus(MRSA) was 32.1%.And that of meticillin-resistant coagulase negative Staphylococcus(MRCNS) was 33.3%.That of extended spectrum ?-lactamases(ESBLs) producer in E.coli and Klebsiella pneumoniae was 34.5%.Various pathogenic bacterium had been resistant to antibiotics to different extents.100.0% of Gram-positive cocci were sensitive to vancomycin.The sensitivity rate to imipenem in Gram-negative bacilli was 19.0-100.0%.CONCLUSIONS Drug resistance variesd from pathogenic bacterium in surgical infection.The clinician should reasonably choose antibiotics according to results of bacterial culture to avoid occurrence and prevalence of drug-resistance bacterium.

Withdrawing medical treatment is quite common among patients with malignant tumors in present clinical practice in China,which is considered as a form of passive euthanasia and serious violation against social ethics and medical purposes.In this paper,the behaviors and reasons for withdrawing treatment of patients with malignant tumors are analyzed,and concerned solutions are explored as well.

Objective:To evaluate the effect of alkalinized lidocaine with endotracheal intubation intracuff injection on the occur-rence of cough and sore throat in the smoking patients after operation. Methods:A prospective and double-blind trial was carried out. Totally 50 smoking patients undergoing surgery under general anesthesia were enrolled. The patients were randomly allocated to receive either ETT intracuff injection of alkalinized 2% lidocaine (group L) or ETT intracuff injection of 0. 9% saline (group S). The inci-dence of cough and sore throat in the two groups was compared. The duration of anesthesia and the time between anesthesia termination and extubation were also recorded. Results:Group L was superior to group S in reducing cough (P<0. 001). The incidence of postop-erative sore throat in group L was significantly lower than that in group S in the post-anesthesia care unit (PACU) (P<0. 05). How-ever, the incidence of sore throat was not significantly different in the two groups at 24h after the extubation (P>0. 05). Conclusion:The intracuff injection of alkalinized lidocaine is superior to saline in decreasing the incidence of postoperative cough and sore throat in smoking patients.

Objective To study the mechanism of the signaling pathway-related LncHOTAIR on the invasion and metastasis of hepatocellular carcinoma(HCC) and provide experimental basis for the treatment of liver cancer with target gene level.Methods Thirty specimens of liver cancer and tissue adjacent to carcinoma on liver and gallbladder surgery surgical resection were collected in the People′s Liberation Army General Hospital from September 2012 to June 2013.Expression of LncHOTAIR,vascular endothelial growth factor(VEGF) and endothelial growth factor receptor(VEGFR) in Hepatocellular Carcinoma and Paracancerous Tissues were detected by Real-time Quantitative Real-time PCR,the relationship between the pathological features and the pathological features of the patients with HCC was analyzed.Results The expression of LncRNA HOTAIR,VEGF and VEGFR were higher in HCC tissues than that in adjacent tissues,which was closely related to tumor size(P=0.512,0.003,0.008),TNM staging(P=0.094,0.001,0.014),portal vein thrombosis(P=0.065,0.046,0.031),invasion and metastasis (P=0.002,0.046,0.031) and 2-year recurrence((P=0.001,0.003,0.021).Conclusion Lnc HOTAIR-related VEGF signal pathways are closely related to the development of liver cancer,si-HOTAIR is expected to become a new focus in the clinical treatment of liver cancer in the future.

Objective:To investigate the methyl-CpG-binding protein 2 (MeCP2) expression in specimens of pancreas cancer tumor and para-cancerous tissues and its prognostic value.Methods:The tissue microarray and immunohistochemistry were used to examine the MeCP2 expression in 59 cases of pancreatic cancer tumor tissues and 53 adjacent normal tissues. The correlation between the MeCP2 expression and clinicopathological characteristics of pancreas cancer patients was analyzed. Furthermore, the survival curve was drawn by Kaplan-Meier method and the Cox regression hazards model was used to study the prognostic value of MeCP2 expression in pancreas cancer.Results:The MeCP2 positive expression rate in 59 pancreas cancer tumor tissues was 47.5%, which was 67.9% in 53 adjacent tissues. The MeCP2 positive expression rate in adjacent tissues was obviously higher than that in pancreatic cancer tissues, and the difference was statistically significant ( P<0.05). The MeCP2 positive expression was significantly associated with pathological grade and lymph node metastasis(both P<0.05). The overall survival in patients positive for the MeCP2 expression was longer than that in those with negative MeCP2 expression( P<0.05). Cox multivariate analysis demonstrated that the level of MeCP2 expression was an independent predictor for prognosis in patients with pancreas cancer. Conclusions:MeCP2 is obviously positively expressed in para-cancerous tissues, but was lowly expressed in pancreatic cancer, indicating that MeCP2 detection can help to evaluate the prognosis of pancreatic cancer patients.

Adult ; Carcinoma, Neuroendocrine ; metabolism ; pathology ; Diagnosis, Differential ; Female ; Hodgkin Disease ; metabolism ; pathology ; Humans ; Ki-1 Antigen ; metabolism ; Leukocyte Common Antigens ; metabolism ; Lung Neoplasms ; metabolism ; pathology ; surgery ; Lymphoma, Large B-Cell, Diffuse ; metabolism ; pathology ; Lymphoma, Large-Cell, Anaplastic ; metabolism ; pathology ; surgery ; Melanoma ; metabolism ; pathology ; Mucin-1 ; metabolism ; Pneumonectomy ; Poly(A)-Binding Proteins ; metabolism ; Receptor Protein-Tyrosine Kinases ; metabolism ; T-Cell Intracellular Antigen-1

Objective To evaluate the curative effect of the atorvastatin calcium tablet(trade name:lipitor) in curing essential hypercholesterolemia.Methods 76 patients with essential hypercholesterolemia were divided into two groups randomly:43 patients in the research group(lipitor tablet 10mg,qn);33 patients in the comparison group (simvastatin tablet 20mg,qn).The period of treatment for both two groups was 6 weeks.The changes of blood fat were detected before and after taking the medicine.The curative effect were compared at the same time.Resnlts The total cholesterol(TC)of the research groups decreased by 37.06%,the TC of the comparison group decreased by 22.05%.The triacylglyceride(TG)of the research group decreased by 24.81%,however,the TG of the compar- ison group decreased by just 14.49%.The low-density lipoprotein cholesterol(LDL-C)of the research group de- creased by 42.30% while the comparison group just decreased by 28.30%(P＜0,01).Also,the high-density lipoprotein cholesterol(HDL-C)of the research group increased by 7.80%,and the comparison group increased by 7.13%(P＞0.05),The effective rate of the research group was 95.35%.For the comparison group,the effective rate was 90.91%.Conclusion The lipitor has a good curative effect in curing essential hypereholesterolemia.Also, the lipitor has fewer side effect,This medicine is safe and reliable for patients.

Objective To evaluate the effects of nucleoside/nucleotide analogue treatment on immunoglobulin and complement in patients with chronic hepatitis B (CHB).MethodsA total of 157 CHB patients were recruited and divided into CHB group,liver cirrhosis (LC) group and severe hepatitis B (SHB) group.There were 50 patients who received oral antiviral treatment (lamivudine 100 mg/d,or entecavir 0.5 mg/d,or telbivudine 600 mg/d).Serum levels of complement 3 and 4 (C3,C4),C-reaction protein (CRP),hemolytic complement (CH50),immunoglobulin G,M,A (IgG,IgM,IgA),hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) were detected by enzyme-linked immunosorbent assay (ELISA) or immunoturbidimetry.Hepatitis B virus (HBV) DNA was quantified by real-time polymerase chain reaction (RT-PCR) before and 1,2,3 and 4 weeks after nucleoside antiviral therapy.Comparison of means was done by t test and Mann-Whitney test.The correlation was analyzed by Pearson correlation coefficient test.ResultsSerum IgA and IgM levels of SHB and LC patients were significantly higher than those of CHB patients (P＜0.01).Levels of C3,C4,CH50 and CRP were significantly different among three groups.Levels of C3,IgM,IgG and HBV DNA in HBeAg positive patients were significantly different from those in HBeAg negative patients.There was a statistically significant difference of IgA,IgM,C3 and CH50 levels between patients with high HBV DNA level and low HBV DNA level in HBeAg-positive patients.While in the HBeAg-negative patients,only the IgA level was significantly different with HBV DNA levels.After anti-viral treatment,immunoglobulin and HBV DNA levels were all decreased in three groups,while the serum complement level was increased compared to baseline,and the differences became significant at week 4 of treatment. HBV DNA level was negatively correlated with C3 (r=-0.78,P=0.021) and HBeAg titer was positively correlated with C3 (r=0.87,P=0.015).ConclusionsThe immunoglobulin,CRP,C3,C4,and C H50 could reflect the inflammatory activity in liver.The changes of C3 level can predict the efficacy of antiviral therapy.