Objective To analyze the levels of serum lipoprotein (a)[Lp(a)]and homocysteine (CHY)in type 2 diabetes mellitus (T2DM)patients and todetermine the relationship between them and diabetic insulin resistance.Methods A total of 108 patients with T2DM and 50 healthy volunteers (control group)were studied.T2DM group according to the presence of kidney disease complications could be divided into simple diabetes group (SDM)in 48 patients with diabetic nephropathy (DN)group of 60 cases.Collected patients general data and determined two groups of glycosylated hemoglobin (HbA1c), low density lipoprotein (LDL),urea nitrogen (BUN),serum creatinine (SCr),urinary inhibition C (CysC),Lp(a)and HCY levels;Compared differences between groups and how they related to T2DM kidney disease,and the relationship between in-sulin resistance.Results ①Compared between three groups only the weight (NC group 60.1±10.34 kg,SDM group 67.2 ±11.38 kg,DN group 68.8±1.35 kg),the difference was statistically significant (F=0.457,P=0.035).②compared be-tween the three groups,the levels of HbA1c (F=3.421,P=0.013),LDL-C (F=2.963,P=0.041),BUN (F=4.637,P=0.031),SCr (F=2.369,P=0.024),CysC (F=3.697,P=0.011),Lp(a)(F=1.236,P=0.021),HCY (F=4.317,P=0.027)were increased significantly.③FPG,FINS and HOMA-IR in SDM group were 5.99±0.94 mmol/L,61.11±28.46 pmol/L and 2.93±1.97 respectively,FPG,FINS and HOMA-IR in DN group were 9.01±2.23 mmol/L,98.56±62.14 pmol/L and 4.34±2.74 respectively.Compared between the two groups,FPG (t=0.47,P=0.017),FINS (t=0.55,P=0.039),HOMA-IR (t=0.69,P=0.024)differences were statistical significance.④The Lp(a),HCY were significantly pos-itive correlation with HOMA-IR (r=0.761,P=0.044;r=0.840,P=0.021).Conclusion Lp(a)and HCY levels in serum associated with diabetic nephropathy,and insulin resistance.And the detection of serum Lp(a)and HCY has important sig-nificance for early detection of diabetic nephropathy.

Objective Understanding of red blood cell distribution width (RDW-CV),blood homocysteine (HCY),lipoprotein a [LP(a)] a merger with high blood pressure and high blood,coronary heart disease (CHD) relevance and explore its clinical application value in CHD.Methods 563 cases of patients with high blood pressure were enrolled,which divided into 62 cases of primary hypertension,501 cases of hypertension combined with coronary heart disease,according to the results of coronary angiography.141 normal cases were chosen as control group.Compared the three groups of RDW-CV,HCY and LP (a) level,the group of coronary artery disease was divided into Ⅰ,Ⅱ,Ⅲ and Ⅳ,and compared the RDW-CV level of each group,and the correlation between RDW and cardiac function was analyzed.Results ①Heart disease groups RDW-CV,LP (a) and HCY (13.25 ± 1.22％,17.82 ± 8.36 μmol/L,172.05 ± 122.32 mg/L) were higher than blood pressure groups (12.98 ± 0.57 ％,14.35 ± 6.36 μ mol/L,124.49 ± 75.88 mg/L) and normal control group (11.41 ± 2.85 ％,11.41 ± 2.85 μmol/L,71.07±27.55 mg/L,P＜0.05).②RDW-CV and HCY were positively correlated with the mental function classification (r=0.461,0.1970;P=0.000,0.032).③The area under the ROC curve was the order of the diagnostic value:HCY ＞LP(a) ＞RDW-CV.LP(a) sensitivity was 82.5 ％ and specificity was 31.7 ％.RDW-CV sensitivity was 48.8 ％ and specificity was 22.2 ％.Conclusion High levels of RDW-CV,HCY,and LP(a) were closely related to the occurrence of coronary heart disease;RDW-CV and HCY were related to the severity of coronary heart disease and cardiac function,and could be a potential biomarker for the development of cardiac function of coronary heart disease.

Objective:To explore the protective effects of breastfeeding on behavioral problems at 4 years in children born to mothers with gestational diabetes mellitus (GDM).Methods:Based on the Ma' anshan Birth Cohort (MABC) study, 305 GDM women and their children were recruited in this study from Ma' anshan Maternal and Child Health Care Hospital from May 2013 to September 2014. Total breastfeeding duration was followed up at 42 d, 3, 6, 12, and 18 months postpartum as well as the breastfeeding intensity within 6 months. All the subjects were divided into breastfeeding group ( n=256, including exclusive breastfeeding and mixed feeding) or bottle feeding group ( n=49). Internalizing and externalizing behavioral problems at age 4 were assessed using Achenbach Child Behavior Checklist (CBCL/1.5~5) and their association with breastfeeding were analyzed using robust Poisson regression. Controlling false discovery rate was applied for multiple test correction. Results:Compared with bottle feeding, breastfeeding was a protective factor for depression in children ( RR=0.23, 95% CI: 0.05-0.98, q=0.048) when the duration was 4-5 months; for somatic complaints ( RR=0.36, 95% CI: 0.14-0.95, q=0.047) and anxiety ( RR=0.19, 95% CI: 0.06-0.62, q=0.010) with a breastfeeding duration of 6-11 months; and for depression ( RR=0.46, 95% CI: 0.25-0.83, q=0.039) and anxiety ( RR=0.12, 95% CI: 0.03-0.49, q=0.006) with a breastfeeding duration of 12 months and above. Compared with bottle feeding within 6 months, mixed feeding had a protective effect on somatic complaints ( RR=0.29, 95% CI: 0.13-0.64, q=0.026) and anxiety ( RR=0.18, 95% CI:0.07-0.52, q=0.002). Conclusions:The findings suggested that breastfeeding had a protective effect on behavioral problems at age 4 in children exposed to GDM. Women with GDM should be encouraged to breastfeed.

Currently, as the key raw material of artificial biological heart valve, bovine pericardium is mainly depend on import and has become a "bottleneck" challenge, greatly limiting the development of domestic biological heart valve. Therefore, the localization of bovine pericardium is extremely urgent. In this study, the pericardium of Sichuan yak was compared with that of Australian cattle in terms of fundamental properties and anti-calcification performance. The results demonstrated that the appearance and thickness of yak pericardium were more advantageous than the Australian one. Sichuan yak pericardium and Australian cattle pericardium had comparable performance in shrinkage temperature, mechanical test and anti-calcification test. This study preliminarily verifies the feasibility of substitution of Australian cattle pericardium by Sichuan yak pericardium and promotes the progression of bovine pericardium localization with data support.
Animals ; Australia ; Bioprosthesis ; Cattle ; Heart Valve Prosthesis ; Pericardium