Objective To investigate clinical significance of detection of serum high sensitiv-ity C-reactive protein (hs-CPR)of patients with primary hypertension.Methods A total of 152 patients with primary hypertension were divided into 3 groups according to the classification of hy-pertension.All patients were suggested to have low-salt and low-fat diet and proper physical exercise and received antihypertensive therapy.After half a year,hs-CPR levels before and after observation period were analyzed and compared with healthy people.Results Levels of hs-CRP before and after observation period were higher than that of healthy people (P <0.01).The hs-CRP levels of level 2 and level 3 of hypertension were obviously higher than level 1 of hypertension before grouping(P <0.05).After observation period,hs-CRP levels of level 1,level 2 and level 3 of hypertension were significantly lower than that before grouping in each group (P <0.05)while level 2 and level 3 were markedly higher than that of level 1 (P <0.05).Conclusion Primary hypertension has ob-viously increased hs-CRP and hs-CRP,so they have a strong relationship with the occurrence of hy-pertension.Therefore,effective control of blood pressure can obviously reduce the hs-CRP level.

Objective To investigate clinical significance of detection of serum high sensitiv-ity C-reactive protein (hs-CPR)of patients with primary hypertension.Methods A total of 152 patients with primary hypertension were divided into 3 groups according to the classification of hy-pertension.All patients were suggested to have low-salt and low-fat diet and proper physical exercise and received antihypertensive therapy.After half a year,hs-CPR levels before and after observation period were analyzed and compared with healthy people.Results Levels of hs-CRP before and after observation period were higher than that of healthy people (P <0.01).The hs-CRP levels of level 2 and level 3 of hypertension were obviously higher than level 1 of hypertension before grouping(P <0.05).After observation period,hs-CRP levels of level 1,level 2 and level 3 of hypertension were significantly lower than that before grouping in each group (P <0.05)while level 2 and level 3 were markedly higher than that of level 1 (P <0.05).Conclusion Primary hypertension has ob-viously increased hs-CRP and hs-CRP,so they have a strong relationship with the occurrence of hy-pertension.Therefore,effective control of blood pressure can obviously reduce the hs-CRP level.

Objective:To investigate the expression of IGF1R-Ras and RAGE-HMGB1 signaling pathways in colorectal cancer patients with type 2 diabetes mellitus and their significance.Methods:The resected cancer tissues were obtained from 59 patients with colorectal cancer (CRC), including 29 patients with type 2 diabetes mellitus (CRC/DM group) and 30 with CRC alone (CRC group). The expressions of IGF1R, Ras, RAGE and HMGB1 in cancer tissues were detected by immunohistochemistry. The differences between the two groups were compared and the relationship between the expression and clinicopathological characteristics was analyzed.Results:In CRC/DM group, the positive rates of IGF1R and Ras were both 65.5% (19/29), and 51.7% (15/29) patients had IGF1R+ Ras+ immunophenotype, which were significantly higher than those in CRC group [33.3% (10/30), 36.7% (11/30) and 20.0% (6/30); P=0.013, 0.027 and 0.011, respectively]. The expression of IGF1R and Ras in CRC / DM group was positively correlated ( r=0.479, P=0.017). The positive rate of RAGE expression in CRC group and CRC/DM group was 70.0% (21/30) and 72.4% (21/29) respectively, and the positive rate of HMGB1 expression was 46.7% (14/30) and 58.6% (17/29) respectively, neither was observed with significant difference ( P=0.358 and 0.838). However, the proportion of patients with RAGE+ HMGB1+ immunophenotype in CRC/DM group [55.2% (16/29)] was higher than that in CRC Group [26.7% (8/30)] which was statistically significant ( P=0.026), and the expression of both proteins was positively correlated in CRC/DM group ( r=0.578, P=0.003). The clinicopathological analysis showed that in both groups the expression of IGF1R, Ras, RAGE and HMGB1 had no correlation with the sex, age, differentiation degree, tumor length, T stage and lymph node metastasis ( P>0.05). Conclusion:Both IGF1R-Ras and RAGE-HMGB1 pathways may be involved in the oncogenesis of colorectal cancer in patients with type 2 diabetes.

Objective:To investigate the expression of IGF1R-Ras and RAGE-HMGB1 signaling pathways in colorectal cancer patients with type 2 diabetes mellitus and their significance.Methods:The resected cancer tissues were obtained from 59 patients with colorectal cancer (CRC), including 29 patients with type 2 diabetes mellitus (CRC/DM group) and 30 with CRC alone (CRC group). The expressions of IGF1R, Ras, RAGE and HMGB1 in cancer tissues were detected by immunohistochemistry. The differences between the two groups were compared and the relationship between the expression and clinicopathological characteristics was analyzed.Results:In CRC/DM group, the positive rates of IGF1R and Ras were both 65.5% (19/29), and 51.7% (15/29) patients had IGF1R+ Ras+ immunophenotype, which were significantly higher than those in CRC group [33.3% (10/30), 36.7% (11/30) and 20.0% (6/30); P=0.013, 0.027 and 0.011, respectively]. The expression of IGF1R and Ras in CRC / DM group was positively correlated ( r=0.479, P=0.017). The positive rate of RAGE expression in CRC group and CRC/DM group was 70.0% (21/30) and 72.4% (21/29) respectively, and the positive rate of HMGB1 expression was 46.7% (14/30) and 58.6% (17/29) respectively, neither was observed with significant difference ( P=0.358 and 0.838). However, the proportion of patients with RAGE+ HMGB1+ immunophenotype in CRC/DM group [55.2% (16/29)] was higher than that in CRC Group [26.7% (8/30)] which was statistically significant ( P=0.026), and the expression of both proteins was positively correlated in CRC/DM group ( r=0.578, P=0.003). The clinicopathological analysis showed that in both groups the expression of IGF1R, Ras, RAGE and HMGB1 had no correlation with the sex, age, differentiation degree, tumor length, T stage and lymph node metastasis ( P>0.05). Conclusion:Both IGF1R-Ras and RAGE-HMGB1 pathways may be involved in the oncogenesis of colorectal cancer in patients with type 2 diabetes.