Objective To assess the predictive value of body mass index(BMI),waist circumference(WC),waist-to-hip ratio(WHR)and waist-to-height ratio(WHtR)for hypertension at the population level.Methods Data from a medical center's database about 48 753 subjects who were 35 to 74 years old in Taiwan was analyzed.Receiver operating characteristic(ROC)curve analysis was done.The areas under the ROC curves for BMI,WC,WHR and WHtR with hypertension were computed and compared.Results The AUC for every anthropometric index with hypertension was significantly larger than 0.5.Compared to BMI,WC and WHR,the AUC for WHtR with hypertension was the largest(male 0.686,95% CI:0.679～0.694;female 0.759,95% CI:0.751～0.767).The AUC for female WHtR with hypertension was significantly larger than male's.Among these AUCs,the AUC for BMI,WC,WHR and WHtR was the largest(male 0.693,95% CI:0.686～0.701;female 0.770,95% CI:0.762～0.778).Conclusions WHtR,prior to BMI,WHR,WHR,may be the best obesity-related index to discriminate adult hypertension,especially for women in Taiwan.

Objective To evaluate the prognostic significance of extent of resection (EOR) in patients with gradeⅢglioma, and the MRI sequence best related with tumor volume. Methods Ninety-six cases were studied retrospectively who were diagnosed as glioma of grade Ⅲ gliomas at Dalian Medical University Affiliated Hospital of Dalian Municipal Central Hospital during the period from 2010 to 2015. EOR was calculated using preoperative and postoperative contrast-enhanced T1-weighted and T2-weightedfluid attenuated inversion recovery (T2Flair) MR images. Univariate and multivariate analyses were performed to evaluate the correlation between EOR and overall survival (OS). Results The results of univariate analysis showed that patients with age<50 years(P=0.032), preoperative KPS>80 scores (P<0.01), no edema (P=0.005), postoperative chemotherapy (P<0.01) and T2Flair EOR≥68% (P<0.01) had better prognosis. Cox multivariate regression analysis showed that age(P=0.008), edema (P＝0.003), postoperative chemotherapy(P=0.000) and T2Flair EOR (P=0.004) were independent factors of prognosis for grade Ⅲ glioma patients. Conclusions T2Flair-EOR is one of the most significant prognostic predictors in patients with grade Ⅲ gliomas. An important survival advantage is associated with T2Flair-EOR≥68% for patients with gradeⅢgliomas.

Extracellular vesicles (EV) are highly heterogeneous nanoscale vesicles secreted by cells. They carry various bioactive molecules derived from the parent cells. EV are widely distributed in various body fluids, showing enormous potential in liquid biopsy and disease treatment. However, conventional flow cytometers face challenges in detecting single EV with a diameter smaller than 300 nm. The nano-flow cytometry (nFCM) developed based on Raleigh scattering and sheath-flow single-molecule fluorescence detection has successfully pushed the detection limit of EV to 40 nm. Through multi-parameter detection at the single-particle level, nFCM enables simultaneous analysis of particle size, particle concentration, and multiple biochemical properties of individual EV. nFCM can be applied to clinical diagnosis and therapeutics based on EV.