Metformin has been used in treating the patients with polycystic ovary syndrome (PCOS) for more than a decade.This article discusses its effect on the improvement of ovulation and hyperandrogenemia.

The prevalence of polycystic ovary syndrome (PCOS) in fertile aged women is about 6%. Many studies show that insulin resistance in PCOS is closely associated with metabolic disorders, which may even potentially increases the risk for cardiovascular diseases. Therefore, metabolic disorders in PCOS should be controlled more actively.

Recently, in the field of pathogenesis and treatment of type 2 diabetes, incretin is a major breakthrough. Based on the knowledge about physiological mechanism, pathological characters, and clinical application, this review article summarized the mechanism of nutrients ( glucose, fat, and protein) mediated incretin secretion, the impairment of incretin secretion and action in type 2 diabetes and glucagon-like peptide-1 's use in type 2 diabetic patients.

The author has done a clinical trial of health education project in 53 cases of mild or moderate hypertension patients aged 35-75 years.He investigates and compares the differences of patients' awareness of the disease,compliance of doctor's advice,control of blood pressure before and after the implementation of health education,then discusses the role of health education in hypertension treatment and puts forward several medical ethical issues existed in the treatment of hypertension.

High level of eetopie serum ACTH can not be suppressed by endogenous or exogenous glucocorticoid, this is the cardinal characteristic of ectopic ACTH syndrome (EAS), that is to say there exists glucocorticoid resistance in EAS. However, the mechanism of glucocorticoid resistance remains unclear. Identifying the mechanism can help us to diagnose and treat the disease. This review focuses on the mechanism of glucocorticoid resistance from several aspects, including the pre-glucocorticoid receptor (GR), GR and post-GR.

The CHealth and MedlinePlus?were comparatively analyzed in aspects of their authority, resource de-velopment, information organization and usage, and website design with suggestions proposed for the construction of public health information websites in China.

Idiopathic hypogonadotropic hypogonadism(IHH) is a complex oligogenic disease.About 60％ of patients are associated with anosmia or hyposmia,also known as Kallmann syndrome. Based on genetic and molecular biological research,about more than ten IHH responsible genes have been discovered.

Objective Through carries on propaganda educates and synthesizes the intervention to some bank staff about hypertension,diabetes mellitus etc.Enhances the service crowd health consciousness,the self control skill and the quality of life.Methods After phvsical examination and so on comprehensive collection service crowd's healthy information,carries on the health risk to appraise,simultaneously adopts the way which the companion educates to guarantee the health management the long-term characteristic,the validity,and regularly carries on the appraisal to the health management effect.Results Through to service object health management,hypertension,the diabetes elementary knowledge knows insufficient rate from 60%enhances to 90% above,its main harm knows rate from 29.52%(31/105)enhances to 83.81%(88/105).Conclusions Enhanced service correlation states-of-art and self-control ability and so on crowd's hypertension,diabetes through the health management,active control hypertension,diabetes and so on disease incidence rate,reduce complication,reduce death rate,improved the service crowd's quality of life.

Objective:To induce an anti-hCG? antibody response in reproductive tract and the peripheral by oral inoculation with a recombinant alive Lactobacilli expressing hCG? in different strains of mouse.Methods:The 108,109,1010 Lb.hCG?, a recombinant Lactobacillus expressing hCG?, were inoculated orally into 6-8-week-old female BALB/c and C57BL/6 mice. The immunized mice were all boosted with the same dose at interval of 3 weeks. An indirect ELISA was used to determine anti-hCG? IgG and IgA antibodies in vaginal lavage and serum that were got at the end of 2-8 weeks after the primary immunization. The B and T lymphocytes of spleen, uterus and vagina were prepared respectively, and their proliferation was analyzed by flow cytometry. The numbers of the cells secreting anti-hCG? IgG or IgA antibody were detected by ELISpot.Results:Inoculation of 109 or 1010 alive Lb.hCG? could induce similar response while 108 induce a lower attitude of response. The antiserum of either 109 or 1010 Lb. hCG? immunization after booster could neutralized more than 100 ng/ml of hCG antigen both in BALB/c and C57BL/6 mice. The B cell proliferation of the reproductive mucosa was more significantly higher than that of spleen in BALB/c mice(P

Objective To investigate the biomechanical changes of internal maxillary distraction with fixation between cleft palate.Methods Three-dimensional FEM models of LeFort Ⅰ osteotomy and soft tissue in CLP maxillary complex were established.Two different conditions were simulated:one was the cleft palate connected by a titanium plate,and the other was the cleft retained.Internal midface distraction which applied in clinic were simulated.Fixation points of the distraction devices on the LeFort Ⅰ osteotomy complex were advanced by 10 mm in the direction of frontage.Biomechanical changes for different conditions were investigated by means of finite element analyses.Results LeFort Ⅰ osteotomy of maxillary complex area in CLP was advanced.Constrictions occurred in alveolar crest and palate,when the cleft was retained.Constriction of alveolar crest and palate was not obvious,when the cleft palate was connected by a titanium plate.There were no differences between sagittal and vertical displacement to internal distraction in LeFort Ⅰ osteotomy.Clockwise rotation occurred in vertical direction.Conclusions Internal maxillary distraction with fixation between cleft palate could avoid constriction of alveolar crest and palate.It provides the options and reference to the surgical plans.