1.Application of "people oriented" concept to construction of teacher's team in university
Chinese Journal of Medical Science Research Management 2008;21(6):356-358
The author described the application of "people oriented" management concept to the construction of teacher's team of the university in four aspects:talent recruitment;the stability and the sustainable development of current team:the management of teacher's team,the rationalization of incentive mechanism.And the author also put forward some corresponding proposal and solution in the construction of teacher's team of the university.
2.Consideration for improving Research Capacity of Medical Post-Doctor
Chinese Journal of Medical Science Research Management 2016;29(3):206-208
Medical post-doctor is an active and indispensable part in the field of medical research,making contribution to the development of medicine.This paper discussed the evaluation index of post-doctor and pointed out that the main ways to improve the research capacity of medical post-doctor including selection of excellent PhD students,evaluation,effective incentive and making full use of the leading role of co-supervisors.
3.Pivotal factors of health care conditions and demands among urban and rural elderly patients with chronic disease in China
Shuling CHENG ; Xiaoying ZANG ; Yue ZHAO
Chinese Journal of Practical Nursing 2012;28(23):66-70
Objective To investigate the situation and demands of the nursing services for both urban and rural elderly people with chronic diseases in China,so as to provide basis of establishing the new elderly care mode. Methods 1902 urban and rural elderly with chronic diseases in almost 29 provinces had been enrolled by the convenience and stratified sampling method to complete the investigation. Results The utilization of relevant nursing care and the demand of psychological counseling and hospice care in cities and towns were higher than those of villages.The demand of common chronic diseases in towns were all higher than that in cities and villages.The demand of pain management in cities wee lower than that in towns and villages.73.3% of elderly in the survey will choose community to subsequent recovery after discharge.The physical,psychological health and economic status might be the pivotal factors. Conclusions At present,endowment in community becomes an inevitable trend in China.Meanwhile,there are still lots of problems in our community health care services,so it remind relevant staffs that some measures should be taken to change such situations.
4.Determination of Gastrodin in Qianglitianmaduzhong Capsule by HPLC
Longqiong CHENG ; Li LIU ; Xiaoying ZHOU
China Pharmacy 2005;0(18):-
OBJECTIVE: To develop an HPLC method for the determination of Gastrodin in Qianglitianmaduzhong capsule. METHODS: The samples were separated on Diamond C18 column (250 mm?4.6 mm,5?m).The mobile phase consisted of acetonitrile - 0.1% phosphoric acid(2∶98) at a flow rate of 1.0 mL?min-1.The UV detection wave length was set at 210 nm and the column was kept at room temperature. RESULTS: The linear range of Gastrodin was 0.126 4~3.160 0 ?g(r=0.999 8), and the average recovery was 98.30%(RSD=0.8%,n=6).CONCLUSION: The method is suitable for the determination of gastrodin in Qianglitianmaduzhong capsule.
5.Study on Optimization of Extraction Technology of Flavonoids from Glechoma longituba by the Integration of Aqueous Two-Phase Partitioning with Ultrasonic Extraction
Mingjian CHENG ; Xiaoying CHEN ; Qihui HUANG
China Pharmacy 2007;0(27):-
OBJECTIVE:To optimize extraction technology of flavonoids from Glechoma longituba by aqueous two-phase partitioning with ultrasonic extraction.METHODS:The extraction technology of flavonoids from G.longituba were optimized by orthogonal experiment with ultrasonic extraction time,the volume fraction of propanol,the ratio of solid to solution,amount of(NH4)2SO4 as factors and with extraction rate of flavonoids from G.longituba as index.RESULTS:The optimal conditions were as follows:extracting for 30 min with ultrasonic wave,the volume fraction of propanol 50%,the ratio of solid to solution 1:30,and the amount of(NH4)2SO4 30%.CONCLUSION:Established extraction technology which is characterized with simple operation and mild conditions shows great advantage.
6.Clinical evaluation of the treatment of open comminuted tibiofibular fractures near articulation with three dimensional external fixators
Cheng CHEN ; Yuelin ZENG ; Xiaoying NING
Chinese Journal of Orthopaedic Trauma 2002;0(04):-
Objective To evaluate the method, clinical effects and influential factors of using three dimensional external fixators in the treatment of severe open comminuted tibiofibular fractures 5 cm near the knee or ankle joints. Methods We retrospectively analyzed 32 cases of open comminuted tibiofibular fracture 5 cm near the knee (11 cases) or ankle joints (21 cases). They were treated with three dimensional external fixators from October 2000 to May 2005. The patients with small wounds were treated with manipulative reduction or leverage reduction through the wound under the guidance of C-arm radiography. In case of malreduction or soft tissue being tangled by the fracture ends, visible reduction was carried out after the wound was lengthened or a small incision was added. Limited internal fixation was used in case of necessity. The results were evaluated in terms of shortening of the fractured limbs, X-ray manifestation, bilateral flexion differences and postoperative walking complaints. Results Follow-ups from 5 to 18 months (nine months on average) showed that all the cases achieved osseous union. The mean union time was 5.6 months. The total excellent and good rates of fracture healing and functional recovery were 81.3% and 87.5% respectively. Conclusion Application of the three dimensional external fixator is appropriate for the treatment of severe open comminuted tibiofibular fracture 5 cm near the knee or ankle joints, because its operative procedure is simple, the injury it causes is minimal, its fixation is reliable and its complications are quite limited.
7.The Clinic Study on the Treatment of Maxillary Protrusion Malocclusion with Micro-Screw Palatal Implant Anchorage
Xiaoying LI ; Cheng PENG ; Yi GUO ; Weie SUN ; Xiaoying CHEN ; Dong WANG
Tianjin Medical Journal 2014;(5):487-489
Objective To investigate the clinic application of micro-implant anchorage in the treatment of maxil-lary protrusion malocclusion. Methods Twenty-two patients,aged 18 to 25 years old,with maxillary protrusion were divid-ed into two groups:experimental group and control group with 11 patients in each group. All patients were treated with ex-traction. Micro-screw palatal implant was used in the cases of experimental group as orthodontic anchorage ,and traditional anchorage composed of extraoral arch used in the cases of control. The cephalometric films were measured before and after treatment. Statistical methods were utilized to analyze the morphological changes of facial profile and hard tissues in both groups. Results The values of U1-NA(mm:3.08±1.18 vs 8.15±3.05) and U1-SN(101.90°±3.50° vs 117.90°±6.05°) were sig-nificantly decreased after treatment compared with those before treatment in the experimental group ( P<0.01). The value of U1-L1(123.98°±5.78°vs 103.89°±8.95°) was significantly increased after treatment (P<0.01). In control group, the values of U1-NA (mm:5.01±1.34 vs 9.12±2.13) and U1-SN(101.90°±3.97° vs 114.87°±7.69°)were significantly decreased after treat-ment. The values of U1-L1(126.01°±3.12°vs 112.98°±5.98°) and U6-PtPNS(mm:21.45±2.43 vs 18.36±2.19)were significant-ly increased after treatment (P<0.05). The value of U1-L1(19.48°±8.90° vs 13.01°±5.90°) was significantly changed in exper-imental group than that of control group, but the value of U6-PtPNS(mm:0.90±0.29 vs 3.78±0.12)was significantly changed in control than that of experimental group (P<0.01). Conclusion The maxillary protrusion malocclusion with micro-im-plant anchorage can be used as treatment for patients with maxillary protrusion that needs strong anchorage.
8.Maxillary protraction and multiple loop edgewise arch wire technology in treatment of early mixed dentition skeletal class Ⅲ malocclusion
Xiaoying LI ; Min HOU ; Cheng PENG ; Jiangtao CUI ; Yan SUN
Chinese Journal of Medical Aesthetics and Cosmetology 2013;(2):106-109
Objective To evaluate the orthodontic effect of surgery on mixed dentition period class Ⅲ malocclusion and to investigate the effective therapeutic method of the skeletal class Ⅲ malocclusion.Methods A total of 20 patients aged 8.5 to 9.1 years with early mixed dentition class Ⅲ skeletal malocclusion.The treatment was divided into two phases.During the first phase,the entire stuffy group was treated with a bonded maxillary expansion and protraction.During the second phase,the entire study group received multiple loop edgewise arch wire (MEAW) treatment until an ideal occlusion relationship achieved.Comparison of the pre-and post-orthodontic treatment cephalometric radiographs had been done after maxillary protraction and MEAW were applied for patients.Results In the 20 patients after orthodontic treatment,Class Ⅲ skeletal facial profile was improved,the retraction of anterior teeth was obvious,and there were significant changes in dentition; the profile of soft tissue and satisfactory occlusion relationship were significantly improved,as compared with the changes between pre-treatment and post-treatment.Conclusions Skeletal Ⅲ malocclusion in early mixed dentition can be successfully treated.The results can be satisfied with improved class Ⅲ skeletal and molar relationship,high-angle and profile of soft tissue.
9.Constructing a tissue-engineered dental root by seeding dental papilla cells into poly(lactic-co-glycolic acid)/sodium alginate hydrogel
Hongyan GUO ; Xiaoling WANG ; Peng XU ; Xiaoying ZHU ; Cheng YANG
Chinese Journal of Tissue Engineering Research 2013;(42):7389-7395
BACKGROUND:Studies addressing reconstruction of tooth tissue engineering have shown that tooth structure can be constructed using tissue engineering technology. Tooth root and its periodontal attachment are critical for tooth survival and functions, based on which, whether we can target root tissues with simple structure for tissue engineering construction by bypassing a complex dental tissue engineering concept with the structural integrity?
OBJECTIVE:To construct a tissue-engineered dental root by seeding dental papil a cells, as seed cells, into poly(lactic-co-glycolic acid)/sodium alginate hydrogel.
METHODS:Rabbit dental papil a cells were isolated and cultured. The cells were then mixed with 1%sodium alginate hydrogel at a final density of 6×109/L. The cellsuspension was seeded into a poly(lactic-co-glycolic acid) scaffold with predetermined shape of human tooth and solidified with calcium chloride. Final y, the cel-scaffold composites were subcutaneously implanted into the back of nude mice. The specimens were harvested after 4 and 8 weeks respectively and processed for gross inspection, X-ray and CT examination and histological observation.
RESULTS AND CONCLUSION:The newly formed tissue kept the original shape of human dental root 4 and 8 weeks post-implantation. After 4 weeks of implantation, the specimen density was low;the root implants appeared to be incompletely mineralized, alginate hydrogels were degraded, but the copolymer scaffold was not degraded;a number of dentin-like structure appeared, and a fibrous membrane structure was visible on the surface of specimens paral el to the root surface, but the structure was not continuous, and no pulp cavity formed. After 8 weeks, the newly formed tissue was highly mineralized close to root tissue of the nature tooth;the copolymer scaffold was mostly degraded;specimens appeared to have a large number of mature dentin-like structure, and form continuous fibers membrane on the surface paral el to the root surface, below which, cementum-like structure formed. Artificial dental root with biological y similar structures of human dental roots can be constructed using the method of tissue engineering.
10.The role of serum uric acid in different types of coronary heart disease
Xiaoying LI ; Ruiying YANG ; Hailiang WU ; Cheng MA
Clinical Medicine of China 2009;25(12):1253-1257
Objective To detect the mechanism of serum uric acid (UA) in different types of coronary heart disease (CHD).Methods 88 patients were divided into three groups:the control group,stable angina (SA) group and acute coronary syndrom (ACS) group.The levels of UA,alpha-granule membrane protein 140 (GMP-140),von Willebrand factor(vWF),plasminogen activator inhabitor typed (PAI-1),Thromboxane B_2 (TXB_2) and C-reacting protein(CRP) were measured.Results ①UA and CRP in ACS group were higher than that in SA group and control group [(392.1±68.57) μmol/L and (42.2±39.4) mg/L vs (370.50±58.80) μmol/L and (18.9±17.1) mg/L vs (286.00±65.31) μmol/L and (2.5±0.7) mg/L,P<0.05)].For UA,there was no difference between ACS and SA group(P>0.05);CRP was higher in ACS group than in SA group (P<0.05).②vWF and TXB_2 were higher in ACS[(1.65±0.48)%,(19.73±18.66)ng/L]and SA group[(1.35±0.49)%,(11.18±10.71) ng/L]than in control group[(1.07±0.26)%,(6.46±5.41) ng/L,P<0.05],and those were higher in ACS group than in SA group (P<0.05).③GMP-140 and PAI-1 were higher in ACS [(13.04±0.99) μg/L and (65.65±14.76) μg/L]and SA group[(12.55±0.74) μg/L and (62.69±12.24) μg/L]than in control group [(12.32±0.29) μg/L,(50.78±13.88) μg/L,P<0.05].There were no differences between ACS and SA group (P>0.05).④Comparing hyperuricemia group and non-hyperuricemia group in CHD patients:the CRP(71.3±18.9) mg/L,vWF(1.08±0.52) %,GMP-140(13.57±1.11) μg/L,TXB_2 (57.26±47.84)ng/L,PAI-1 (72.12±9.23) μg/L in ACS group possessing hyperuricemia were higher than non-hyperuricemia group [CRP (20.7±17.9) mg/L,vWF (0.84±0.54) %,GMP-140 (13.23±1.07) μg/L,TXB_2 (26.70 + 23.83) ng/L,PAI-1 (61.30±12.07) μg/L](t=7.394,0.008,0.227,7.605,0.421,P<0.05);CRP(31.1±18.9)mg/L and TXB2 (21.54±3.90) ng/L in SA group possessing hyperuricemia group were higher than non-hyperuricemia group[(10.9±10.1)mg/L and (5.02±4.93) ng/L,t=0.494,8.669,P<0.05].Logistic stepwise regression analysis indicated that the related factors with ACS were UA(OR=1.046),CRP(OR=7.615),PAI-1(OR=1.301),PT(OR=0.300)and TG(OR=2.243) (P<0.05).Conclusions UA is an important risk factor in CHD patients.UA can induce different types of CHD by damaging blood vessel endothelium function,activating platelet,changing coagulation and causing inflammatory.