1.Application of elastic registration based on Demons algorithm in cone beam CT.
Journal of Biomedical Engineering 2014;31(1):103-106
We applied Demons and accelerated Demons elastic registration algorithm in radiotherapy cone beam CT (CBCT) images, We provided software support for real-time understanding of organ changes during radiotherapy. We wrote a 3D CBCT image elastic registration program using Matlab software, and we tested and verified the images of two patients with cervical cancer 3D CBCT images for elastic registration, based on the classic Demons algorithm, minimum mean square error (MSE) decreased 59.7%, correlation coefficient (CC) increased 11.0%. While for the accelerated Demons algorithm, MSE decreased 40.1%, CC increased 7.2%. The experimental verification with two methods of Demons algorithm obtained the desired results, but the small difference appeared to be lack of precision, and the total registration time was a little long. All these problems need to be further improved for accuracy and reducing of time.
Algorithms
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Cone-Beam Computed Tomography
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Humans
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Image Interpretation, Computer-Assisted
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Imaging, Three-Dimensional
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Software
2.A clinical study for radiotherapy positioning with references images on CT simulator
Bo YANG ; Xiaoyang SUN ; Huiqun LUO ; Hong WU ; Haowen PANG
Chinese Journal of Radiation Oncology 2011;20(1):54-56
Objective To explore a new method of comparing the references images first to enhance the precision of the central point of the radiation treatment planning(RTP), try to establish a reference standard for this method in the nasopharyngeal cancer(NPC)and carcinoma of utercin cervix in the work of position verification. Methods For 50 RTPs of NPC and 20 RTPs of carcinoma of utercin cervix, the reference-CT-images in set-up and in position verification were compared, and to measure the difference between the two images. Then, in the same way, compare and measure the difference in the central-pointimages. Results For NPC, there was over 90% RTPs in which every difference measured was less than 2 mm;for carcinoma of utercin cervix, over 80% RTPs meet the criterion:the value of △MU1 ' or △MU2' was less than 5 mm and the others are less than 3 mm. Conclusions By comparing the references-CT-images in set-up and in position verification, the precision of the central point of the RTP is enhanced. The marks on the skin become more credible. So, it is feasible to perform the criterions in the work of position verification:for NPC every difference measured is less than 2 mm;for carcinoma of utercin cervix the value of △MU1 ' or △MU2 ' is less than 5 mm and the others are less than 3 mm.
3.A study of the iso-center point coincidence between accelerator and radiotherapy planning system
Xiaoyang SUN ; Bo YANG ; Haowen PANG ; Guangpeng ZHANG ; Jing ZHANG ; Renjin CHEN ; Jingbo WU
Chinese Journal of Radiation Oncology 2016;25(6):625-627
Objective To study the iso-center point coincidence of two accelerators with treatment planning system (TPS) based on γ passing rates of intensity-modulated radiotherapy (IMRT) plan verification.Methods Twenty-one IMRT plans were verified by Varian accelerator and twenty by Elekta accelerator with a gamma criterion of 3 mm/3%.The passing rates were measured when the iso-center point of TPS had-2,-1,0,1,and 2 mm shift in the x or y direction.A binomial curve of γwas fit to figure out the values of the two accelerators on the x and y axes when γ value reached the maximum.The γ pass rate difference was analysed by x2 test.Results The mean values of γ-2,γ-1,γ0,γ1,and γ2 in the x direction were (92.56±3.27) %,(96.53± 1.82) %,(96.13± 1.41) %,(90.14± 2.87) %,and (82.28± 4.69) % for Varian accelerator,and (94.82± 2.04) %,(97.05± 2.02) %,(98.38± 1.33) %,(97.96± 1.44) %,and (94.49±2.34)% for Elekta accelerator.There was no significant difference in the mean value of γ0between the two accelerators (P=0.332).When γvalue reached the maximum,the values on the x and y axes were0.65 and-0.30 mm for Varian accelerator and 0.01 and 0.30 mm for Elekta accelerator,respectively.Conclusions In the same TPS,different accelerators have different degrees of coincidence of the actual field center point with the iso-center point of TPS,to which more attention should be paid in clinical practice.
4.Relationship between the overlap volume of organ at risk and target and the dose to organ at risk in intensity-modulated radiotherapy
Haowen PANG ; Xiaoyang SUN ; Bo YANG ; Xiangxiang SHI ; Tao TANG ; Jingbo WU
Chinese Journal of Radiation Oncology 2017;26(2):187-191
Objective To explore the relationship between the overlap volume of organ at risk (OAR) and target (Voverlap) and the mean dose to OAR (DmOAR) in intensity-modulated radiotherapy (IMRT).Methods Fifty randomly selected patients undergoing IMRT for nasopharyngeal carcinoma (NPC) and an equal number of patients undergoing radical IMRT for cervical cancer in our hospital were enrolled as subjects.The relationship between Voverlap and DmoAR in IMRT was analyzed.The Matlab software was used to generate function to fit the relationship between Voverlap and DmOAR for different OARs.Results The Voverlap varied among patients with NPC or cervical cancer.The ratio of Voverlap to the volume of OAR (VOAR) was positively correlated with the ratio of DmOAR to the prescribed dose (Dp) (all P=0.01).A function was generated to fit the correlation between Voverlap/VOAR ratio and DmOAR/Dp ratio.Conclusions In IMRT,patients have different Voverlap/VoAR ratios due to varicd target volume,disease stages,OAR filling status,and OAR volume.As criteria for plan verification,a specific DmOAR value for each OAR should be calculated before radiotherapy planning based on the corresponding correlation function and the Voverlap/VoAR ratio with a fixed dose prescription.It can be used to reduce the subjective influence on the optimization of radiotherapy planning.
5.A novel surgical technique for dissecting perforator vessel in anterolateral thigh perforator flap: Orderly retrograde four-side dissection
Juyu TANG ; Liming QING ; Panfeng WU ; Zhengbing ZHOU ; Fang YU ; Xiaoyang PANG ; Ding PAN ; Lei ZENG ; Yongbing XIAO ; Rui LIU
Chinese Journal of Microsurgery 2021;44(2):137-140
Objective:To introduce a novel surgical technique for dissecting perforator vessels (orderly retrograde four-side dissection) in anterolateral thigh perforator flap (ALTPF) and explore its clinical outcome.Methods:Respective analysis of 94 patients who underwent reconstruction of soft tissue defects with ALTPF which were dissected by orderly retrograde four-side dissection between June, 2013 and December, 2016. After surgery, the survival of flaps, recovery in shape and function of the recipient sites, and the effect on shape and function of the donor sites were observed.Results:The size of ALTPF ranged from 7 cm×5 cm to 32 cm×10 cm. Ninety-four perforators were included in 94 ALTPF, which were 89 perforators of the descending branch of circumflex femoral lateral artery, 4 perforators of the transverse branch of circumflex femoral lateral artery and 1 perforator of femoral medial artery. The time for flap harvesting was 35-95(54.39±16.39) min. Success rate of perforator harvesting was 98.9%, only 1 perforator was injured and another encountered vasospasm during surgery. Three cases had vascular crisis after flap transfer with 2 venous crises and 1 artery crisis. All of the flaps completely survived except 1 that had a partial necrosis. The follow-up time was (12.91±9.17) months. No muscular weakness on donor sites was shown in all cases.Conclusion:Orderly retrograde four-side dissection of perforator vessels in the ALTPF has achieved less donor site morbidity, shorter surgical time and is safer than the traditional techniques. It is a reliable technique to harvest perforator flaps.
6.Special forms of perforator flap in reconstruction of complex and exceptionally large defects of both lower extremities in child: A case report
Fang YU ; Juyu TANG ; Panfeng WU ; Xiaoyang PANG ; Lei ZENG ; Yongbing XIAO ; Ding PAN ; Liming QING ; Rui LIU
Chinese Journal of Microsurgery 2021;44(2):221-223
A child who suffered a complex and exceptionally large soft tissue defects of both lower extremities and feet was referred in January, 2017. A debulking deep inferior epigastric perforator (DIEPF) was used to cover the defect in right shank. The defects in left shank and foot were reconstructed by latissimus dorsi flap and bilateral debulking anterolateral thigh perforator flap (ALTPF) . Two years after operation, the appearance and texture of both lower limbs were good, and the child could walk and run almost normally. There were slightly noticeable scars left in both thighs and the back.
7. Preliminary observation of the safety of template-assisted 192Ir source hypofractionated stereotactic ablative brachytherapy for locally advanced non-small cell lung cancer
Xiangxiang SHI ; Tao TANG ; Haowen PANG ; Xiaoyang SUN ; Jingbo WU ; Sheng LIN
Chinese Journal of Radiation Oncology 2019;28(9):665-668
Objective:
To preliminarily evaluate the safety of the coplanar template-assisted 192Ir hypofractionated stereotactic ablative brachytherapy (SABT) in patients with locally advanced non-small cell lung cancer (LA-NSCLC), and assess the effect of template-assisted technology upon the accuracy of SABT by comparing the consistency of dosimetric parameters between preoperative and operative plans.
Methods:
Fifteen patients histologically confirmed with LA-NSCLC (stage ⅡB-ⅢA) were recruited and received the template-assisted SABT delivered in a risk-adapted fractionation (30 Gy/1F). Preoperative planning, template-assisted needle implantation, operative planning and implementation were performed in all patients. Dosimetric results of preoperative and operative plans were statistically compared by assessing the dosimetric parameters of gross tumor volume (HI, CI, D90, V100 and V150) and organ at risk(V5, V20 and mean dose of bilateral lung, D2cc of spinal cord. The incidence of perioperative complications of SABT was recorded. The safety and feasibility of SABT were evaluated.
Results:
Slight changes were noted in terms of target dose and irradiated dose to the lung between preoperative and operative plans without statistical significance (both
8.Recent advance in epilepsy associated with autoimmune encephalitis
Xiaoyang CHAI ; Jie WANG ; Qian PANG ; Fei HU ; Keyu YANG ; Zan DONG
Chinese Journal of Neuromedicine 2019;18(2):207-210
Autoimmune encephalitis (AE) is a novel form of encephalitis associated with antibodies to cell-surface or synaptic proteins. Epileptic seizures act as the predominant manifestation of AE which are triggered by interaction between kinds of antibodies and antigens on cell-surface or intracellular. Patients with AE-related epilepsy are insensitive to antiepileptic drugs but sensitive to immunotherapy. Early initiation of immunotherapy can significantly improve the prognosis. To date, there are few reports on the treatment plan of antiepileptic drug to the patients with AE-related epilepsy. In this review we report the most relevant data about the morbidity, pathogenesis and treatment of AE-related epilepsy with aim of providing better treatment options.
9.Effect of needle arrangement on the lung dose in interstitial brachytherapy for lung cancer
Bo YANG ; Xiaoyang SUN ; Haowen PANG ; Xiangxiang SHI ; Guangpeng ZHANG ; Longjing TAN ; Renjin CHEN ; Tao TANG ; Hong WU ; Jingbo WU
Chinese Journal of Radiation Oncology 2017;26(12):1417-1420
Objective To analyze the effect of needle arrangement on the lung dose in interstitial brachytherapy for lung cancer. Methods For 15 patients undergoing interstitial brachytherapy for lung cancer, a virtual radiotherapy plan in which needle arrangement was not restricted by the ribs was designed and compared with the original plan. For the two plans, V5, V20, V30, and mean lung dose(MLD)of the whole lung were determined when the prescribed doses were 10,30, 60, and 120 Gy, respectively. The data were analyzed by Wilcoxon signed-rank test. Results The lung V5,V20, V30, and MLD were significantly smaller in the virtual plan than in the actual plan(all P<0.05). Conclusions Irregular needle arrangement prevents a further reduction in the lung dose in interstitial brachytherapy for lung cancer. In the implantation surgery, therefore, the needles should be arranged as regularly as possible.
10.Propeller flap based on the terminal dorsal perforator of proper palmar digital artery for reconstruction of fingertip defects
Zhengbing ZHOU ; Ding PAN ; Juyu TANG ; Panfeng WU ; Fang YU ; Yangbing XIAO ; Lei ZENG ; Xiaoyang PANG ; Liming QING ; Rui LIU
Chinese Journal of Microsurgery 2018;41(2):152-155
Objective To investigate the feasibility and efficacy of using the propeller flaps based on the terminal dorsal branch of proper palmar digital arteries for fingertip reconstruction.Methods From September,2013 to September,2016,25 fingers (25 patients) underwent fingertip reconstruction by using propeller flaps pedicled with the terminal dorsal branch of digital arteries.There were 18 males and 7 females with mean age of 33 years.The injured fingers requiring reconstruction included 13 index,6 middle,5 ring and 1 little fingers.The size of the propeller flaps:small paddles were 0.6 cm×0.4 cm-2.1 cm×0.4 cm;big paddles were 3.0 cm×1.3 cm-5.5 cm ×2.0 cm.The donor sites were closed directly in 16 cases,and skin graft appiled in 9 cases.Results Twenty-three cases fingertip defects were successfully reconstructed with this flap.One case of flap necrosis occurred,requiring secondary revision using a cross-finger flap.Donor sites healed without any complication.The mean follow-up period was 11.5 months (range:7-29 months).Fingers restored good shape and function.At 6 months after surgery,the 2-point discrimination value was 6.5 mm (range,6-10 mm).In 2 cases,protective sensation was successfully restored.The postoperative extension and flexion function was evaluated by the total active movement (TAM) system of finger joints:excellent in 20 fingers,good in 4 fingers and fair in 1 finger.The excellent and good rate was 96%.Conclusion The propeller flap based on the terminal dorsal branch of the proper palmar digital arteries to repair fingertip defect has advantages of achieving good function,appearance and minimized damage to the donor site,which is a effective method in reconstructing the fingertip defect.