Objective To investigate the expression and clinical significance of ubiquitin-like with PHD and ringfinger domains 1(UHRF1) in benign and malignant pleural effusion.Methods From November,2015 to February,2017,130 cases of pleural effusion were collected in Jiangning hospital of Nanjing,including 54 cases of malignant pleural effusion caused by lung cancer and 76 cases of lung benign pleural effusion.And the latter contained 36 cases of tuberculous pleural effusion and 40 cases of inflammatory pleural effusion.Enzyme-linked immunosorbent assay (ELISA) were used to detect the level of UHRF1 in each group,and the relationship between UHRF1 and clinical pathology was analyzed.Results The level of UHRF1 437.28± 140.05 ng/L in patients with lung cancer was higher than that 338.47± 163.72 ng/L in patients with benign lung diseases,and the differences were statistically significant (t=3.596,P=0.0005).The level of UHRF1 470.59 ± 127.74 ng/L in patients with non-adenocarcinoma was higher than that 377.78± 145.81 ng/L in patients with adenocarcinoma,and the differences were statistically significant(t=2.329,P=0.023).In group with benign lesion,there were no sig nificant differences (t =1.374,P =0.174) between the level of U HRF1 365.51 ± 167.54 ng/L in tuberculous pleura l effusion and the level of UHRF1 314.13± 158.34 ng/L in inflammatory pleural effusion.And the level of UHRF1 in benign and ma lignant pleural effusion was not related to age,sexuality and smoking history.Conclusion UHRF1 is a potential marker in the differential diagnosis of benign and malignant pleural effusion.

The medical development in the 21th century will present a very societal and synthetical trend. The medical education in 21th century is sure to comply with the needs of medical development.We must change idea, regulate education content, expand education intension and renew education goal to train high-quality medicine personnel with comprehensive ability.

The research on the problem of subjectivity education which inherits and surmounts the traditional education is an important orientation in the development of the education reform theories.Subjectivity education follows the objective law governing the development of education and the inherent requirements of the comprehensive development of man.Subjectivity education which has become the theme of contemporary education is to be the main melody in the 21st century.

As the doctor - patient relation becomes more and more strained, the former study on the relation between these two parts, done only from the perspective of medical ethics, has been found far from enough. Many -sided factors, in fact, contribute to it. The government reduces investment into medical field; the medical insurance coverage shrinks; welfare sense in state - run medical organizations decreases; doctors focus on medical procedures, ignore humane care to patients; the cost for treatment is increasing and the sense of self - protection of the patients is growing and so on. Therefore, it is of critical importance to study the relation from multi -perspective for the reconstruction of harmonious doctor - patient relation in the future.

At present,most of the physiological teachers of medical university in our country have graduated from medical universities,and have never been trained by special teachers.Because of the influence of medical education training mode and cultural environment factors,teachers' teaching ability and teaching level are different.This paper proposed the full range of skills training for teachers through microteaching.To enhance the in-service teachers' teaching ability and professional level of development,the design procedures of the microteaching training should include the establishment of tutor teaching system,training teachers preparing lessons,after-school peer experts review,self-evaluation and improvement of the video after watching video and questionnaire evaluation,etc.

Magnetic resonance imaging has developed from a single observation of organisms’ anatomy and the change of morphology under the physiological and pathological conditions to the study of biology function and activity mechanism. Furthermore, it has entered into the molecular imaging and functional magnetic resonance imaging (fMRI), and diffusion-weighed imaging (DWI) is one of them, which is mainly used in the early diagnosis of cerebral infraction. This article elaborates diffusion-weighed imaging,the identification of acute and non-acute cerebral infarction by DWI in physiological basis of pathogenesis and the time vale of DWI examination. The author holds the opinion that it is of great significance to distinguish between acute and non-acute cerebral infarction by using DWI and that clinicians may adopt targeted therapies according to the different periods of cerebral infarction in order to avoid unsafe and unnecessarily risky treatments.

Today’s medical imaging has developed from a single observation of organisms’ anatomy and the change of morphology under the physiological and pathological conditions to the study of biology function and activity mechanism. Furthermore, it has entered into the molecular imaging. Through the analysis of 25 academic monograph and the experiences of convening three national editorial committees, the author successfully analyzes. Before writing, the author should carry out the market research and the writings should be deigned for a readership. The writing team must be equipped with academic quality as well as humanistic quality. And the comprehensive quality of the premier author is of great importance. He needs to call together all the members of the committee to have an all-round and deep communication, do the job as unifying the drafts, advertise sales and revise.

To investigate the effect of herbal drugs for clearing away heat, removing dampness and killing parasites,which are used for washing on tinea pedis. Two hundred and eight cases confirmed as tinea pedis were randomized to two groups: group A (n=108) and group B (n=100). Group A was treated with Xiaoxuan Lotion (mainly composed of Radix et Rhizoma Rhei, Herba Artemisiae Scopariae, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Stemonae, etc.) and group B with miconazole nitrate cream. Two treatment courses were carried out. After one treatment course, 65 (60.2%) cases were cured in group A and 45 (45%) in group B, the difference being significant (P

Medical humanistic education becomes “remarkable leaning” because many problems arise from the development of contemporary medicine such as the meaning of life,the medical aim,the medical model and doctor-patient relationship etc.Multi-channel and multi-modal development of medical humanistic education has become a must to understand medicine and makes it develope soundly,and all-directional resultant force and the environment of medical humanistic education,striving for studies,is an exploration and even a mission and responsibility

Objective To investigate uncertainty in illness of family members of patients with malignant tumor,to explore the factors that affect uncertainty in illness of family members of patients with malignant tumor,and to provide clinical basis for clinical doctors and nurses implementing effective interventions for their patients.Methods Questionnaires were conduted to investigate uncertainty in illness of family members of patients with malignant tumor and explore the related factors.The measurements included three parts,Chinese version of Mishel uncertainty in illness scale for family member,self-designed questionnaire about family general condition,patients disease information.Results The total score of uncertainty in illness was 82.71±9.93,more than 50 ％ (75 score) of the highest PPUS-FM score.There were statistical significances of uncertainty in illness in education (F =8.06,P ＜ 0.05),family income (F=3.14,P ＜ 0.05),residence place (F =3.99,P ＜ 0.05) and frequency of hospitalization (F =4.85,P ＜ 0.05).Conclusion Family members of patients with malignant tumor have a higher level of uncertainty in illness.Education,family income,residence place and frequency of hospitalization have a certain effect on uncertainty in illness of family members of patients with malignant tumor.