1.Retrospective Analysis of ADR Occurred in Our Hospital in 2009
Ya GENG ; Baohong CHEN ; Xiaoyan MU
China Pharmacy 2005;0(20):-
OBJECTIVE:To understand the status quo adverse drug reactions(ADR) occurred in our hospital and to promote clinical use of drugs.METHODS:By retrospective analysis,study 73 ADR cases collected from our hospital in 2009 were analyzed in respect of gender and age of patient,route of administration,category of drugs,organs and systems involved in ADR and its clinical manifestation.RESULTS:Of total 73 ADR cases,35.6% of cases were induced by anti-infective agents and 9.6% traditional Chinese medicines.Most of cases were caused by intravenous administration.Main clinical manifestations were lesion of skin and its appendents.CONCLUSION:Rational use of anti-infective agents and traditional Chinese medicine(TCM) should be strengthened.Quality control and standard application of TCM injection should be enhanced to reduced or avoid the incidence of ADR.
2.Application of Clinical Data Interchange Standards Consortium (CDISC) Standards to Electronic Data Capture System
Geng LI ; Xiaoyan LI ; Zehuai WEN
World Science and Technology-Modernization of Traditional Chinese Medicine 2017;19(2):332-338
Data acquisition is one of the key links that influencing the quality of clinical research.Electronic data capture system (EDC) embodies the advantages of saving time,manpower and material resources and improving efficiency and reliability by data acquisition.CDISC has established worldwide industry standards to support the electronic acquisition,exchange,submission and archiving of clinical research data.The application of CDISC standards to EDC system is favorable in ensuring the validity and standardization of clinical data.This paper takes the Oracle's OC/ RDC (Oracle Clinical / Oracle Remote Data Capture) system as an example to discuss the application of CDISC standard to EDC system from the two aspects:direct application and indirect application.We suggest that data collection should be taken into account during the design phase of a clinical trial,and the CDISC standard be applied at the CRF design stage.A design for eCRF takes time and effort by the combination of EDC system and CDISC standard,while thoughtless design may collect the wrong data.Therefore,it is suggested that a specialized personnel should be put in charge of eCRF design and maintenance during the operation of EDC system,and a set of standardized eCRFs based on CDISC standard and standard operating procedures should be built in one organization.
3.Concept analysis of self-management in the context of coronary heart disease based on the content analysis
Yuying SHI ; Lei DING ; Xiaoyan ZHAO ; Guiling GENG
Chinese Journal of Practical Nursing 2014;30(7):66-69
Objective To parse the concept of self-management in the context of coronary heart disease based on the content analysis,to clarify the connotation of the concept of self-management.Methods Thirty-four references were recruited through the databases of CNKI,VIP journals knowledge service platform,Wanfang Data Services Platform and Pubmed.We broke the concept of self-management in the context of coronary heart disease into such three aspects as implementing body,major behavior,and facilitators.Results The most common indicators were symptom management(which was mentioned by 78.57% of domestic literature and 66.67% of foreign literature),and protect and promote healthcame second,the person with the chronic diseasewas 42.85%,other indicators' frequency existed differences.The major body of coronary artery disease self-management was the patient itself,with the help of assist staff and using lifestyle management,symptom management,rehabilitation and exercise,environmental control,emotional awareness behavior management and medication to maintain patients' satisfactory functional status.Conclusions To parse the concept of self-management in the context of coronary heart disease can be applied as the basis for clinical nursing research and build an effective reference and guidance for future coronary heart disease self-management model building.
4.Efficacy of Endoscopic Variceal Ligation Combined with Sclerotherapy for Treatment of Esophageal Variceal Bleeding
Qingya GENG ; Xiaoyan XIANG ; Kun WANG ; Haihuan YING
Chinese Journal of Gastroenterology 2015;(4):241-243
Background:Medical treatment and surgery are the two main therapeutic approaches for esophageal variceal bleeding ( EVB),but studies showed that the efficacy of medical treatment was poor,and surgery was invasive and could lead to serious complications. Aims:To investigate the efficacy and safety of endoscopic variceal ligation combined with sclerotherapy for treatment of EVB. Methods:A total of 150 cirrhotic patients with EVB admitted from May 2011 to May 2012 at Wenling Oriental Hospital were enrolled and assigned into observation group and control group by random digital table. Patients in observation group were treated with endoscopic variceal ligation combined with sclerotherapy,and patients in control group were treated with somatostatin and pantoprazole. Overall clinical efficacy,recurrence and adverse effect were compared between the two groups. Results:In observation group,the overall clinical efficacy was 94. 7%(72/76), the recurrence rate was 3. 9%(3/76),and the adverse effect rate was 13. 2%(10/76);in control group,the overall clinical efficacy was 79. 7%(59/74),the recurrence rate was 14. 9%(11/74),and the adverse effect rate was 28. 4%(21/74). Overall clinical efficacy in observation group was significantly higher than that in control group(P<0. 05), while recurrence rate and adverse effect rate were significantly lower than those in control group( P all < 0. 05 ). Conclusions:Compared with medical treatment,endoscopic variceal ligation combined with sclerotherapy is effective in improving the clinical efficacy and reducing the recurrence and adverse effect for treatment of EVB. It is worthy of being used in clinical practice.
5.Clinical study of carboprost tromethamine combined with motherwort injection in prevention of high-risk ce-sarean section hemorrhage
Xiaoyan DING ; Tao FENG ; Hui GENG ; Fang LIU ; Airong MA
Chinese Journal of Primary Medicine and Pharmacy 2014;(7):1006-1007
Objective To investigate the carboprost ammonia butyl alcohol three plus motherwort injection on prevention of high risk maternal postpartum hemorrhage effect .Methods 120 cases of cesarean section operation and potential bleeding symptom of women were selected as the research object ,and randomly divided into two groups , the observation group of 60 cases using carboprost ammonia butyl alcohol three joint of leonurus heterophyllus injec -tion for prevention and treatment ,the control group of 60 cases used oxytocin for prevention and treatment ,prevention and treatment effects were compared between the two groups .Results After treatment,the observation group 2h,24h postpartum hemorrhage were (422.41 ±213.49)mL,(35.29 ±16.44)mL,were significantly less than those in the control group (589.64 ±345.21)mL,(69.31 ±29.47)mL(t=6.732,8.915,all P<0.05);the observation group 1 cases without production after bleeding ,control group 5 cases of postpartum hemorrhage ,statistically significant differ-ences between the two groups (χ2 =4.973,P<0.05).Conclusion Carboprost ammonia butyl alcohol three plus motherwort injection on prevention of high risk maternal postpartum hemorrhage has a significant effect ,which can re-duce the cesarean section uterine bleeding and reduce the amount of bleeding ,promote uterine involution ,conducive to maternal rehabilitation .
6.Clinical value of 64-row CT angiography in detection of carotid atherosclerotic plaque
Xiaoyan YU ; Weijun TANG ; Ruijiang ZHU ; Haoxiong LI ; Daoying GENG
Chinese Journal of General Practitioners 2009;8(11):792-795
Objective To explore clinical significance of muhidetector(64-row)computed tomography carotid atherosclerosis angiography(MDCTA)in detecting carotid atherosclerotic plaque.Methods Data of 116 patients with carotid atherosclerosis undergone with MDCTA stayed at Huashan Hospital,Shanghai from January to August,2008 were analyzed retrospectively.Results Three hundred and seventy-seven plaques were identified among all the 116 patients in the study,with an incidence of calcified plaque of 63.40 percent,and more detected at the common carotid artery(27.85%).the carotid bifurcation(39.78%)and the internal carotid artery (21.48%).There was significantly statistical difference in plaque types between those with mild,moderate and severe carotid stenosis(P=0.000)and between those aged equal to or lower than 50 years and equal to or greater than 70 years(P=0.005).Plaque types at the common carotid artery were significantly difierent from those at the carotid bifurcation(P=0.000)and at the internal carotid artery(P=0.000).Results of regression analysis showed a positive and significant association between carotid occlusion and clinical symptomatology(with a coefficient of correlation of 1.080.P=0.023)and inverse association between calcified plaque and clinical symptomatology(with a coefficient of correlation of 0.688,P=0.006).Conclusions Not only imaging characteristics of carotid atherosclerotic plaque can be accurately assessed by MDCTA,but also measurement of its stenosis degree.Assessment of plaque type,degree of stenosis and distribution of plaque in different Vascular segments with MDCTA can be used to predict clinical occurrence of cerebevaseular events in patients with carotid atherosclerosis.
7.Rivastigmine hydrogen tartrate on stroke patients with vascular dementia: study of magnetic resonance spectroscopy
Yanyan HUANG ; Xiaoyan WU ; Zhen ZHU ; Daoying GENG
Chinese Journal of Neurology 2000;0(05):-
Objectives To examine the clinical usefulness of magnetic resonance spectroscopy (MRS) on assessment of vascular dementia (VD) in patients with stroke; the relationships between metabolic changes of brain and clinical symptom improvements after giving rivastigmine in these patients.Methods 20 stroke patients without VD, male 17, female 3, with a mean age of (71.7?4.7) years old; 23 stroke patients with VD, male 20, female 3, a mean age of (72.9?5.1) years old; 20 normal volunteers were studied, a mean age of (70.9?4.8) years old. MRS was performed in all these patients. The patients with VD were prescribed rivastigmine hydrogen tartrate ("Exelon", Norvatis), and given MRS assessment half a year later.Results The patients with VD had a significantly lower N-acetyl aspartate/Creatine (NAA/Cr) ratio (mean?SD: left: 0.57?0.30; right: 0.66?0.29) and higher Choline/Creatine (Cho/Cr) ratio (mean?SD: left: 1.79?0.52; right: 1.97?0.44) in bilateral temporal hippocampus area, compared to those without VD (mean?SD: NAA/Cr: left, 0.91?0.31; right, 0.87?0.27, P
8.Prophylactic effect of budesonide on the expression of IL-4, IL-5 in model of allergic rhinitis rats.
Xiaoyan GUO ; Manying GENG ; Zhong LI ; Hui ZHANG ; Xiufen WEI
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2014;28(14):1057-1060
OBJECTIVE:
To explore the prophylactic effect of Budesonide on the expression of IL-4,IL-5 in nasal mucosa in model of minimal persistent inflammation of allergic rhinitis in rats.
METHOD:
Eighty SD rats were randomly divided into allergic rhinitis group (A group), experimental (B group), control group (C group) and negative control group (D group). A group was made for model of allergic rhinitis. B and C group were made for model of the lightest persistent inflammatory response. After the models were established, half of rats in the A group, B group, C group and D group were executed, and EOS infiltration and the expression of IL-4, IL-5, ICAM-1 were observed in nasal mucosa. The remaining rats of B group were given budesonide (64 microg/side/time, twice/day) treatment for 2 weeks. A, C, D group were given nasal spray with normal saline for 2 weeks. After that A, B, and C groups were stimulated with 1% OVA daily for one week, D group were given nasal spray with normal saline. All rats were executed after excitation, EOS infiltration and IL-4, IL-5 expression were observed.
RESULT:
After the drug treatment, B group only had a small amount of mucous EOS infiltration and had no significant difference with D group, but in A and C group EOS had heavy infiltration. Gray value of the IL-4 positive areas in B group were significantly different compared with A and C group (P < 0.05), A group and C group had no significant difference (P > 0.05). Distribution of IL-5 positive signals was similar with that of IL-4.
CONCLUSION
Budesonide MPI application could significantly inhibit the allergic.
Animals
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Budesonide
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therapeutic use
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Disease Models, Animal
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Female
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Interleukin-4
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metabolism
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Interleukin-5
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metabolism
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Male
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Rats
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Rats, Sprague-Dawley
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Rhinitis, Allergic
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metabolism
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prevention & control
9.Study of white matter hyperintensities of Parkinson's disease by MRI
Zhen ZHU ; Daoying GENG ; Liwei SHEN ; Xiaoyan WU
Chinese Journal of Rehabilitation Theory and Practice 2005;11(10):834-837
ObjectiveTo explore the correlation between white matter hyperintensities(WMH) and the clinical features of Parkinson's disease(PD) when examined by magnetic resonance imaging(MRI).MethodsThe correlation between WMH,periventricular hyperintensities(PVH),deep white matter hyperintense signals(DWMH) in MRI and age,disease duration,distribution in 64 patients with PD and 45 age-matched healthy controls was studied.ResultsThe frequency of WMH was higher in patients with PD,but no significant difference compared with controls(P>0.05).The patients with WMH were significantly older(P<0.01) and more severity(P<0.01) than those without WMH,but disease duration was no significant difference(P>0.05).The frequency of DWMH was higher in patients with PD,but no significant difference compared with controls(P>0.05).The patients with DWMH were significantly older(P<0.01) than those without DWMH,but disease duration and severity were no significant difference(P>0.05).The frequency of PVH was higher in patients with PD and having a significant difference compared with controls(P<0.05).The patients with PVH were significantly older(P<0.01) and more severity than those without PVH,but disease duration was no significant difference(P>0.05).The distribution of DWMH was not significantly different between patients with PD and controls (P>0.05),but distribution of PVH was significantly different between patients with PD and controls(P<(0.05)).ConclusionPVH may influence some clinical features of PD characterized by a greater disease severity.
10.Analysis of the effect and safety of atorvastatin in the treatment of septic shock
Jing ZHANG ; Suyan ZHANG ; Xiaoyan GENG ; Aitian WANG ; Jingli GAO ; Xiaolan LI
Chinese Journal of Primary Medicine and Pharmacy 2014;(15):2246-2248
Objective To explore the clinical efficacy and safety of atorvastatin in the treatment of patients with septic shock.Methods 67 patients with septic shock were randomly divided into the treatment group (34 cases) and control group(33 cases).The control group was treated with conventional therapy ,and the observation group was administered with atorvastatin based on the control group .Before and after treatment ,the inflammatory index ,cytokines levels,the number of MODS cases,the number of deaths at 28th day,and the incidence of adverse reactions were com-pared between the two groups .Results The heart rate ,respiratory rate ,white blood cell count of the treatment group were significantly better than the control group ,the cytokines levels were significantly lower than the control group ,the differences were statistically significant (t=4.181,3.622,4.879,all P<0.05).The incidence rate of MODS of treat-ment group was significantly lower than that of the control group (χ2 =7.153,P<0.05).The average hospital stay of the treatment group was (9.3 ±3.1)d,which was significantly less than (12.4 ±3.3)d of the control group(t=3.964,P<0.05).The incidence rate of adverse reaction in the treatment group was significantly lower than that of the control group(χ2 =4.566,P<0.05).The 28 d mortality rate of the two groups had no significant difference (χ2 =3.345,P>0.05).Conclusion Atorvastatin can effectively reduce the degree of inflammatory reaction in patients with septic shock ,decrease the incidence of MODS , and has potential benefits on the prognosis of patients , but still need to be further confirmed by clinical research .