Obiective To realize real-time data processing in lung ventilation reconstruction based on electrical impedance tomography(EIT). Methods The image reconstruction algorithms, plotting functions and matrix calculations are dynamic transferred with Matlab C++, Mathtools and VC++ to meet the requirements of data processing and imaging in real time.Results Image reconstruction and real-time data processing were realized successfully in lung ventilation based on EIT. Conclusion It provides a new strategy for real-time data processing of image reconstruction by EIT.

Objective:To establish a GC method for determining the content of amantadine hydrochloride in pediatric paracetamol and amanatadine hydrochloride granules. Methods:The ingredients were separated on an Agilent DB-5 quartz capillary column (30 m ×0.25 mm, 0.25 μm), the carrier gas was N2,and the flow rate was 1 ml·min-1. The column temperature was maintained at 130℃, the injection temperature was 250℃,the detection temperature was 280℃ with an FID as the detector , the injection volume was 2 μl, and the split ratio was 20∶1. Results:A good linear relationship was obtained between the peak area and the concentration of amantadine hydrochloride within the range from 0.103 2 to 6.456 0 mg·ml-1(r =0.999 9). The average recovery was 100.18%(RSD=0. 11%, n=6). Conclusion:The method is specific, accurate, reliable and reproducible, which can be used in the quality control of pediatric paracetamol and amanatadine hydrochloride granules.

Objective　To observe the curative effect and sid e effect of the gastrokinetic agent mosapride citrate by RCT. Methods　 42 cases of functional dyspepsia (FD) were divided into two groups rando mly, the group of mosapride(21 cases):orally administrated mosapride, 5mg, t.i.d for 4 weeks, and the control (21 cases):orally administrated domperidone, 5mg, t.i.d for 4 weeks. Symptoms and side effects were recorded before and at d 14, d 28 after administration of the medicines according to GCP and double blind pri ciple. Gastric empting test was also carried out in randomly selected patients. Results　Mosapride and domperidone were significantly effective on alleviating symptoms of the patient with FD. In mosapride treated group the half emptying time was shortened and the 120 min remain rate was reduced. No sid e effect was found. Conclusion　These results suggest that mosa pride 5 mg t.i.d. is effective and safe on alleviating symptoms of patients with FD and improving the ga stric empting time.

The study aims to evaluate the bioequivalence of valsartan hydrochlorothiazide tablets, and to investigate the potential cause of bioinequivalence. This was a single-center study with an open, randomized double-way crossover design. Test and reference preparations containing 160 mg of valsartan and 25 mg of hydrochlorothiazide were given to 36 healthy male volunteers. Plasma concentrations of valsartan and hydrochlorothiazide were determined simultaneously by LC-MS/MS. The pharmacokinetic parameters and relative bioavailability were calculated, while the bioequivalence between test and reference preparations were evaluated. The dissolution profiles of test and reference preparations in four different mediums were determined via dissolution test and HPLC. The similarity was investigated according to the similarity factors (f2). The F(o-t) and F(0-infinity) were (139.4 +/- 65.2)% and (137.5 +/- 61.2)% for valsartan of test preparations. It led to get the conclusion that test and reference preparations were not bioequivalent for valsartan. A significant difference was observed between test and reference tablets in the valsartan dissolution test of pH 1.2 hydrochloric acid solution. The key factor of the bioinequivalence might be that dissolution of valsartan in acid medium has marked difference between two preparations.

Objective To explore the status of glucocorticoid application in patients with systemic lupus erythematosus (SLE) in China.Methods Epidemiological survey was used.The SLE patients who met the 1997 classification criteria of American College of Rheumatology were enrolled.The usage of glucocorticoid and related adverse reactions were recorded and analyzed.Results A total of 400 SLE patients were enrolled,including 35 men and 365 women.The average age was (37.4 ± 14.0) years old,and the average duration of disease was (6.7 ± 5.8) years.There were 310 patients using glucocorticoid as maintenance.Sixty-one percent (n =244) patients started using medium dose (prednisone 30-＜ 60 mg/d) as the initial treatment of glucocorticoid,which lasted for (37 ± 11) days.The time of drug duration in patients with low dose prednisone (7.5-＜30 mg/d)and high dose (60-100 mg/d) was(92 ± 20)and (17 ± 3) days respectively (P ＜ 0.05 between 3 groups).However,patients receiving different initial dosage were of no discrepancy in the maintenance therapy.During maintenance,even though 51.0％ (n =158) patients were on prednisone 2.5-5 mg/d,the duration of drug use in ＞ 5-10 mg/d groupwas longer [(29.9 ± 3.3) months].Patients with involvement of internal organs had a higher tendency to use 60-100 mg/d prednisone or pulse-dose therapy in the initial treatment,nevertheless these two groups had no difference of maintenance dosage.Among all 400 patients,62 patients withdrew glucocorticoid,including 17 patients with disease remission (4.3％),44 by self-withdrawal and one with adverse reaction.Conclusion In China,the medium dosage of glucocorticoid is the most common initial treatment in patients with SLE.Prednisone 2.5-5 mg/d was the most common choicefor maintenance therapy.Currently,the proportion of glucocorticoid withdrawal remains low in SLE patients achieving remission.

Objective:To establish an analytical method for the identification of donkey-hide gelatin in Fufang Ejiao Buxue gran-ule.Methods:The identification of donkey-hide gelatin in Fufang Ejiao Buxue granule was established by rapid resolution liquid chro -matography (UPLC) coupled with triple quadruple mass spectrometry (QQQ-MS).Results: The characteristic molecular peaks of donkey-hide gelatin were detected in ten batches of commercial samples .Conclusion:The present method is specific , precise and reli-able, and suitable for the identification of donkey-hide gelatin in Fufang Ejiao Buxue granule .The method provides scientific reference for the study of quality control method for gelatin ingredients in Chinese patent medicines .

In this paper, the respiration courses of human at different postures are reconstructed by electrical impedance tomography (EIT). Conjugate gradient least squares (CGLS) algorithm is applied to reconstruct the resistivity distribution during respiration courses, and the EIT images taken from human at flat lying, left lying, right lying, sitting and prone postures are reconstructed and compared. The relative changes of the resistivity in region of interest (ROI) are analyzed to evidence the influences caused by different postures. Results show that the changes in postures are the most influential factors for the reconstructions, and the EIT images vary with the postures. In human at flat-lying posture, the left and right lungs have larger pulmonary ventilation volume simultaneously, and the EIT-measured data are of lower variability.
Algorithms ; Electric Impedance ; Humans ; Lung ; physiology ; Posture ; Respiration ; Tomography ; methods

Objective To detect ED1 gene mutations in the families with X-linked hypohidrotic ec-todermal dysplasia (XLHED). Methods Blood samples were obtained from 2 pedigrees. All 8 exons and flanking intronic boundaries of ED1 gene were amplified with polymerase chain reaction technique and then directly sequenced. Results Two mutations were found in ED1 gene. One was splicing mutation (IVS8+5 del G), the other was missense mutation (A959G). None of the mutations was found in normal individuals of two XLHED families and in 188 unrelated, population-matched control individuals. Conclusion Out of the ED1 gene mutations identified in 2 Chinese XLHED families, IVS8+5del G is a novel mutation.

Obj ective To compare yhe effecys of ywo enyeral nuyriyion payhways in Geriayric ICU payienys receiving mechanical venyilayion as well as adopyion of effecyive care measures in order yo provide a basis for implemenyayion of enyeral nuyriyion feeding in yhese payienys.Methods A case-conyrol syudy was used.Fifyy ICU payienys receiving mechanical venyilayion were randomly divid-ed inyo nasogasyric yube group and nasoinyesyinal yube group,25 cases for each.Boyh group received proper nursing measures.The yime of achieving yargey dose of nuyriyion,nuyriyion improvemeny in 2,3,4 weeks and yhe incidence of complicayions were analysed.Results The yime of achieving yargey dose in nasoinyesyinal yube group was significanyly less yhan yhose in nasogasyric yube group (P<0.05).Afyer 4-weeks yreaymeny,yhe levels of yoyal proyein,serum prealbumin and yransfer-rin were improved in boyh groups wiyh a significanyly greayer degree in nasoinyesyinal yube group (P<0 .05 ).The incidence of complicayions in nasoinyesyinal yube group is significanyly less yhan yhose in nasogasyric yube group (P<0 .05 ).Conclusion Nasoinyesyinal yube feeding combined wiyh proper nursing measures in elderly ICU payienys receiving mechanical venyilayion makes yhe yargey dose of nuyriyion easily achieved and reduces yhe incidence of complicayions of mechanical venyilayion such as aspirayion and abdominal disyension.

Obj ective To compare yhe effecys of ywo enyeral nuyriyion payhways in Geriayric ICU payienys receiving mechanical venyilayion as well as adopyion of effecyive care measures in order yo provide a basis for implemenyayion of enyeral nuyriyion feeding in yhese payienys.Methods A case-conyrol syudy was used.Fifyy ICU payienys receiving mechanical venyilayion were randomly divid-ed inyo nasogasyric yube group and nasoinyesyinal yube group,25 cases for each.Boyh group received proper nursing measures.The yime of achieving yargey dose of nuyriyion,nuyriyion improvemeny in 2,3,4 weeks and yhe incidence of complicayions were analysed.Results The yime of achieving yargey dose in nasoinyesyinal yube group was significanyly less yhan yhose in nasogasyric yube group (P<0.05).Afyer 4-weeks yreaymeny,yhe levels of yoyal proyein,serum prealbumin and yransfer-rin were improved in boyh groups wiyh a significanyly greayer degree in nasoinyesyinal yube group (P<0 .05 ).The incidence of complicayions in nasoinyesyinal yube group is significanyly less yhan yhose in nasogasyric yube group (P<0 .05 ).Conclusion Nasoinyesyinal yube feeding combined wiyh proper nursing measures in elderly ICU payienys receiving mechanical venyilayion makes yhe yargey dose of nuyriyion easily achieved and reduces yhe incidence of complicayions of mechanical venyilayion such as aspirayion and abdominal disyension.