Objective To explore the clinical efficacy of neoadjuvant chemotherapy on advanced epithelial ovarian cancer.Methods From May 2006 to March 2010,60 patients with Ⅲ-Ⅳ stage advanced epithelial ovarian cancer were collected in Affiliated Cancer Hospital of Shanxi Medical University,which were divided into two groups based on different treatment methods.The observation group used the neoadjuvant chemotherapy,but the control group did not use it.The efficacy,operation time,blood loss,size of residual disease and the level of CA125 were observed to evaluate the safety and clinical efficacy of neoadjuvant chemotherapy.Results The total effective rate in the observation group was 60.0％.The satisfied cytoreductive rate was 70.0％,which was significantly higher than the control group (x2 =5.455,P ＜0.05).The mean operative time (127.21 ±27.62) min (t =10.113,P ＜ 0.05),intraoperative mean blood loss (408.5 ± 112.62) ml (t =5.047,P ＜ 0.05)and the level of CA125 (165.26 ±43.27) U/ml (t =14.100,P ＜ 0.05) in the observation group were significantly lower than the control group [189.33 ± 45.81) min,(590.6 ± 162.41) ml,(339.13 ± 51.86) U/ml].Five year survival rates of the observation group and control group were 36.7％ and 26.7％ respectively,with significant difference (x2 =8.492,P =0.036).Conclusion Neoadjuvant chemotherapy can play a positive role in the treatment of the patients with advanced epithelial ovarian cancer.

Early weaning from mechanical ventilation in children will lead to an extubation failure,however,prolonging mechanical ventilation will increase the risk of ventilator associated complication and the economical burden of disease.Nowadays there is no unified and objective ventilator weaning indexes in pediatrics,so it is significant to searching for appropriate and feasible ventilator weaning indexes.This article detailed the current progress on the condition and predictors of ventilator weaning in children,and comparing the predictability and accuracy of ventilator weaning indexes in children,also looking forward to the possibility of higher accuracy or scheme in ventilator weaning that used for clinical purposes.

Objective To explore the clinical significance of the adenosine deaminase ( ADA) and the pro-calcitonin(PCT) in adult patients with active pulmonary tuberculosis .Methods 81 patients with active pulmonary tuberculosis were enrolled into A group ,43 patients with non-tuberculous lung infection were enrolled into B group and 27 patients with lung cancer were enrolled into C group .Serum ADA and PCT were detected .Tuberculosis patients were treated for 6 months of anti-tuberculosis treatment .Results There was a significant difference between group A and B or C group about ADA (t=12.983,10.630,all P<0.01),B and C groups showed no significant difference (t=0.144,P=0.885).Group A PCT compared with group B were significantly different (t=16.775,P<0.01), the A group and C group showed no significant difference (t=1.571,P=0.119),group B compared with group C were significantly different (t=11.235,P<0.01).Tuberculosis treatment remission in 67 cases,no relief in 14 ca-ses.The levels of serum ADA and PCT in remission were significantly lower than in patients with no remission group (t=3.087,3.404,all P<0.05).Conclusion The serum ADA can be used as diagnostic indicators of active tuber-culosis,ADA and PCT joint determination can determine the prognosis of active tuberculosis .

The retinal vessel changes are the primary and major features of retinal vascular diseases.The retinal vessel is part of systemic vessels with its own characteristics to sustain normal retinal function.These basic characteristics are important to the correct understanding and proper treatment of retinal vascular diseases.Always keep in mind that the retinal vessels is one part of the systemic vascular system,thus retinal vascular diseases may have systemic etiology,and systemic drug administration may have a profound effects to the whole body.However retinal vascular system also has its own structural and functional characteristics,thus retinal vascular diseases are also different from the systemic diseases.Finally the main function of retinal vascular network is to maintain the neuro-retinal function,thus we should balance the vision protection and treatments against abnormal retinal blood vessels.Over-treatments may damage the retinal vision.

Objective To study the clinical efficacy of low -calorie enteral nutrition support therapy for postoperative recovery in patients with primary hepatic carcinoma .Methods Retrospective analysis was performed in this study .120 patients, including partial liver or local liver resection , were divided into Hypocaloric parenteral nutrition group ( HPN) and Hypocaloric parenteral nutrition group ( HEN) by different nutritional treatment ways with each group of 60 case.Liver function ( TBIL, ALT, AST ) , nutrition indicators (ALB, PCHE, PA), immune function (CD4 +T cells, CD8 +T cells, CD4 +T cells/CD8 +T cell ratio), gastrointestinal tract function ( postoperative intestinal ventilation ) , the incidence of complications and nutritional support costs and hospitalization time difference were compared between two groups .Results Compared with the low -calorie parenteral nutrition group , TBIL, ALT, AST were significantly lower on low calorie enteral nutrition group (P<0.05); ALB, PCHE, PA, ALB, PCHE, PA, CD4 +T cells, CD8 +T cells, CD4 +T cells/CD8 +T cell ratio were significantly higher on low calorie enteral nutrition group ( P<0.05);low-calorie gastrointestinal function recovery, incidence of complications during hospitalization and nutritional support costs on enteral nutrition group were superior to low -calorie parenteral nutrition group .Moreover, the differences were statistical significance (P<0.05).Conclusion For postoperative pa-tients with primary hepatic carcinoma , both enteral and parenteral nutrition support therapies have significant effect , however ,enteral nu-trition therapy has more advantages , better clinical efficacy by comparing to parenteral nutrition therapy .Therefore, it is worthy of apply-ing in clinic .

Objective The aim of the present study was to determine the associations between uric acid,lipid and carotid atherosclerosis in the hypertension patients.Methods Eighty participants with essential hypertension were enrolled to undergo by uhrasonography to calculate intima-media thickness (IMT) and carotid artery plaques,each participants were detected UA,serum lipids.Results Multiple regression analysis revealed the UA,TG,LDLC was significantly independently associated with IMT (P＜0.01) in non-plaques participants.UA,LDL-C in the group of carotid atherosclerotic were significantly higer than the group of the normal I MT.Condusion UA,TG,LDL-C were found to be an independent risk factor for incidence of carotid atherosclerosis.

Hedgehog (Hh) pathway plays a critical role in embryonic development period,which regulates cell proliferation and differentiation,and coordinates the key step of organs' development process such as skin,brain,neural tube,bowels,appendage and lung.In the adult stage,Hh signaling regulates proliferation of stem cells.At this time,Hh signaling is strictly controlled by time and space.In recent years,studies have shown aberrant activation of the Hh pathway is closely related to various types of malignancies,and would be a new therapeutic target of tumor treatment.This paper will review the characteristic of Hh signaling pathway and its research status in lung cancer.

Vasovagal syncope (VVS) although is a benign disease,repeated syncope attacks can reduce quality of life in patients,in some cases,can also lead to serious body injures.Therefore,it is required and necessary to the treatment of patients with VVS.The treatment of VVS includes health education,drug treatment and non-drug treatment.

The paper gives a detailed description of the main features of American medical services,the characteristics of American hospitals,the responsibilities of hospital presidents and the problems faced by them.In addition,it introduces the macro-management of American hospitals and the existing problems.

Objective To evaluate the application value of ultrasound-guided minimally invasive stereotactic breast excision in the diagnosis and treatment of breast mass. Methods The minimally invasive operations for 218 patients were performed by ultrasound-guided Mammotome system, and the therapeutic efficacy of Mammotome system was evaluated. Results All the patients were completely excised by the Mammotome system. No failed procedure occurred,all the masses were pathologically confirmed as benign lesions in 214 patients and invasive ductal carcinomas in 4 patients. Postoperatively, the incision scar was barely visible and no complications happened except for mild subcutaneous hemorrhage in 9 patients,local hematoma in 3 patients and local deep pitting of the skin in 5 patients. Conclusion Mammotome system shows many benefits with less trauma, more rapid recovery and with less complications.