1.Data platform based fine management practice of medical devices in hospitals
Manhui ZHANG ; Ying LI ; Xiaoxiao LUAN ; Xiaohua LIU ; Xiaoqi XUE ; Feng XU
Chinese Journal of Hospital Administration 2020;36(7):597-599
Medical device management has become a key to medical quality management, medical risk prevention and medical cost control. Continuous innovation is needed to realize the refinement of device management, ensure the safety of patients and improve medical quality. The authors take MRI as an example to monitor the medical devices based on the data platform support in combination with hospital specifics, so as to provide references for the rational use of medical devices.
2.Exploration of building a smart management platform for large-scale medical equipment in hospitals
Xiaohua LIU ; Boqi JIA ; Xiaoxiao LUAN ; Manhui ZHANG ; Chuankun ZHOU ; Ying LI ; Chaonan XU ; Zhenlin LIU ; Feng XU
Chinese Journal of Hospital Administration 2021;37(10):856-859
Strengthening the supervision over the use of large-scale medical equipment is an effective means to improve the efficiency of equipment use and the quality of medical services, and it is an important part of promoting the construction of the Healthy China and the development of health undertakings. Through four stages of preliminary demand investigation, intelligent collection of data, intelligent analysis and evaluation, and continuous improvement, a large-scale medical equipment intelligent management platform was built in our hospital. Real-time data collection, interconnection, analysis and evaluation were achieved, which could help the use and supervision, improve efficiency and effectiveness, and optimize the evaluation system.
3.Spatiotemporal Dynamics of the Molecular Expression Pattern and Intercellular Interactions in the Glial Scar Response to Spinal Cord Injury.
Leilei GONG ; Yun GU ; Xiaoxiao HAN ; Chengcheng LUAN ; Chang LIU ; Xinghui WANG ; Yufeng SUN ; Mengru ZHENG ; Mengya FANG ; Shuhai YANG ; Lai XU ; Hualin SUN ; Bin YU ; Xiaosong GU ; Songlin ZHOU
Neuroscience Bulletin 2023;39(2):213-244
Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic regeneration of neurons and extrinsic factors - the glial scar is triggered by injury and inhibits or promotes regeneration. Recent technological advances in spatial transcriptomics (ST) provide a unique opportunity to decipher most genes systematically throughout scar formation, which remains poorly understood. Here, we first constructed the tissue-wide gene expression patterns of mouse spinal cords over the course of scar formation using ST after spinal cord injury from 32 samples. Locally, we profiled gene expression gradients from the leading edge to the core of the scar areas to further understand the scar microenvironment, such as neurotransmitter disorders, activation of the pro-inflammatory response, neurotoxic saturated lipids, angiogenesis, obstructed axon extension, and extracellular structure re-organization. In addition, we described 21 cell transcriptional states during scar formation and delineated the origins, functional diversity, and possible trajectories of subpopulations of fibroblasts, glia, and immune cells. Specifically, we found some regulators in special cell types, such as Thbs1 and Col1a2 in macrophages, CD36 and Postn in fibroblasts, Plxnb2 and Nxpe3 in microglia, Clu in astrocytes, and CD74 in oligodendrocytes. Furthermore, salvianolic acid B, a blood-brain barrier permeation and CD36 inhibitor, was administered after surgery and found to remedy fibrosis. Subsequently, we described the extent of the scar boundary and profiled the bidirectional ligand-receptor interactions at the neighboring cluster boundary, contributing to maintain scar architecture during gliosis and fibrosis, and found that GPR37L1_PSAP, and GPR37_PSAP were the most significant gene-pairs among microglia, fibroblasts, and astrocytes. Last, we quantified the fraction of scar-resident cells and proposed four possible phases of scar formation: macrophage infiltration, proliferation and differentiation of scar-resident cells, scar emergence, and scar stationary. Together, these profiles delineated the spatial heterogeneity of the scar, confirmed the previous concepts about scar architecture, provided some new clues for scar formation, and served as a valuable resource for the treatment of central nervous system injury.
Mice
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Animals
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Gliosis/pathology*
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Cicatrix/pathology*
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Spinal Cord Injuries
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Astrocytes/metabolism*
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Spinal Cord/pathology*
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Fibrosis
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Mammals
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Receptors, G-Protein-Coupled