1.Websites of some class A hospital libraries in eastern China
Chinese Journal of Medical Library and Information Science 2016;25(7):64-68
After the status quo of class A hospital libraries websites in eastern China was described, the major reasons that led to such a status quo were analyzed, including irrational staff structure, lack of systematic management ideas and fund support, and certain suggestions were proposed for their solution.
2.Studies on Chemical Constituents from Rubus pinfaensis
Herald of Medicine 2014;(9):1154-1156
Objective To study the chemical constituents from dry roots of Rubus pinfaensis. Methods The compounds were separated from alcohol extracts of the roots of Rubus pinfaensis with silica gel column chromatography,and identified using IR,1 H-NMR and EI-MS methods. Results Five compounds were isolated and identified as oleanolic acid (Ⅰ) ,3-keto,16α-hydroxy,24-noroleanolic acid (II) , 3 '-methoxy myricetin (Ⅲ) , 2 '-deoxyuridine (Ⅳ) and p-hydroxybenzoic acid (Ⅴ) . Conclusion CompoundsⅠ,II,Ⅲ,ⅣandⅤwere isolated from Rubus pinfaensis for the first time.
3.Comparison of Psychological Problems Between the Male and Female Workers in the “Three Form Enterprises”
Huanrong LUO ; Xuejing ZHANG ; Xiaoxian DEN
Journal of Chinese Physician 2002;0(S1):-
Objective To evaluate mental health among male and female workers in the “three form enterprises”. Methods Data from 7779 participants using self-report Symptom Checklist 90 (SCL-90) were statistically analyzed. HZ Results ⑴All the statistical parameters and average factor scores of each item were all significantly higher than the normal group (U test, P
4.Changes in mechanics of respiration and efficacy of mechanical ventilation during perioperative period in patients undergoing valve replacement
Tao HONG ; Yannan HANG ; Xiaoxian ZHANG
Chinese Journal of Anesthesiology 1996;0(09):-
Objective To examine the changes in respiratory mechanics and efficacy of mechanical ventilation during perioperative period in patients undergoing valve replacement and determine the possible causes Methods Twenty ASA Ⅱ Ⅵ patients (8 male, 12 female), aged 24 65 years , undergoing valve replacement were studied The patients were premedicated with intramuscular phenobarbital 0.1g, pethidine 50mg and scopolamine 0 3mg Anesthesia was induced with midazolam, fentanyl and vecuronium and maintained with inhalation of low concentration of desflurane and intermittent intravenous boluses of fentanyl, midazolam and vecuronium Valve replacement was performed with moderate hypothermic cardiopulmonary bypass (CPB), The patients were mechanically ventilated with pure oxygen Tidal volume was maintained at 8 10ml/kg, frequency 12 15 bpm and I∶E ratio 1∶1 5 2 During CPB airway pressure was maintained below 5 cmH 2O After operation the patients were transferred to ICU and mechanically ventilated using Siemens 900C ECG, SpO 2, BP, CVP, left auricle pressure and urine output were routinely monitored Respiratory mechanics was measured with Novametrix 8100 multifunction respiratory monitor Mean airway pressure, peak airway pressure, airway resistance, chest lung compliance and respiratory work were measured 20 min after induction of anesthesia, 10 min before CPB, 10 min after termination of CPB, at the end of operation and 2, 6 and 18h after operation Results Work of breathing and airway resistance increased gradually after induction and reached the maximum at 6h after operation Dynamic compliance decreased significantly before CPB but increased slightly after CPB, then decreased again and to the minimum at 6h after operation Mean airway pressure and peak inspiratory pressure went up significantly after operation All parameters mentioned above returned to the preoperative levels before the patients were weaned from respiratory support in ICU Couclusions Thoracotomy and CPB are the main causes of changes in respiratory mechanics in patients undergoing valve replacement The effects reached the peak at 6 h after operation Therefore mechanical respiratory support is essential for the patients until respiratory function recovers and should be maintained for more than 6h after operation
5.Quantitative Analysis of Five Macroporous Resin Residues
Lixia HU ; Xiaoxian WANG ; Hong ZHANG
China Pharmacist 2015;(3):515-517
Objective:To establish a method for the determination of organic residues ( hexane, benzene, toluene, xylene and sty-rene) in macroporous adsorption resins. Methods:Headspace-GC with a DB-624 column was used to determine the residues in macro-porous resins. The inlet temperature was 200℃ and the FID detector temperature was 240℃. The column temperature programming was as follows:the initial temperature was 40℃, maintained for 3 min, and then raised to 200℃ with the rate of 14℃/min and kept for 2 min. The solvent was methyl alcohol and the carrier gas was nitrogen. HPLC was applied to determine the contents of the five resi-dues. Results:The contents of the five organic residues were all below 20‰ in five macroporous resins in common use including D101, HPD100, AB-8, DM301 and NKA-9. Conclusion:The method is simple,accurate and reproducible. It can be used in the res-idue determination of macroporous resins.
6.Loss of NF2 Gene in Neurofibromatosis Type 2- Associated Cutaneous Schwannomas
Jun ZHANG ; Xiaoxian HE ; Jianping JIA ;
Chinese Journal of Dermatology 1995;0(04):-
Objective The loss of NF2 gene in cutaneous schwannomas of neurofibromatosis type 2 patients was investigated in order to explore the tumorigenesis and characteristics of NF2 tumor suppressor gene, and to provide evidence for presymptomatic gene diagnosis for NF2 patients. Methods DNA was extracted from whole blood and frozen tumor tissue, respectively. Genotyping was performed using 6 microsatellite markers flanking or within the NF2 gene: CRYB2- D22S193- NF2CA1- NF2CA3- D22S268- D22S430, which is tightly linked to the NF2 gene and analyzed on an ABI Genetic Analyzer 310 after PCR amplification. Results A total of 18,14,0,13,16,12 samples showed loss of heterozygosity at microsatellite markers CRYB2, D22S193, NF2CA1, NF2CA3, D22S268, D22S430 in 43 samples of cutaneous schwannomas, respectively. Conclusions The method for detection of NF2 allelic loss was established. Frequent allelic loss reconfirms that NF2 gene is a tumor suppressor gene. The observation that tumors with or without allelic loss of the NF2 gene exist in the same patient indicates that these tumors are originated from different clones in which genetic alterations occurred independently.
7.Effects of doxorubicin on changes of cardiac function and angiotensinⅡ level in myocardium of New Zealand white rabbits
Hui ZHANG ; Rongqin ZHENG ; Xiaoxian QIAN ; Baoshun HAO ; Chengxi ZHANG
Chinese Journal of Pharmacology and Toxicology 2014;(4):497-502
OBJECTlVE To investigate the myocardiaI toxicity of doxorubicin on the myocardium of rabbits and mechanism. METHODS Doxorubicin 2 mg·kg-1 was injected once a week for eight weeks. After discontinuation of doxorubicin,observation was performed for another 8 weeks. Every weekend, uItrasound examination,cardiac catheterization,angiotensinⅡ(AngⅡ)Western bIotting and pathoIogi-caI examination were performed to anaIyze eject fraction( EF),maximaI rate of rise of Ieft ventricuIar pressure(+dp/ dtmax ),AngⅡexpression IeveI,apoptosis index(AI)and the structure of the myocardium. RESULTS At the 7th injection,EF decreased( P ﹤0.05),but reached the bottom vaIue at the 8th injection. At the 3rd injection,Ieft ventricuIar +dp/ dtmax decreased( P ﹤0.05)and reached the bottom vaIue one week after withdrawaI. After that,it increased and reached a high vaIue six weeks after withd-rowaI. But it was stiII Iower than before administration. At the 2nd injection,AngⅡ expression increased (P﹤0.05). At 1 week after withdrawaI,it reached the top vaIue,but than decreased and reached a Iow vaIue six weeks after withdrowaI,but was stiII higher than before administration. At the 1st injection,AI increased( P ﹤ 0.05). At 1 week after withdrawaI,it reached the top vaIue,but then decreased and reached a Iow vaIue 5 weeks after withdrawaI. But it was stiII higher than before administration. CONCLUSlON Doxorubicin cardiac toxicity can induce an eIevated IeveI of myocardiaI AngⅡ,possibIy associated with increased aIdosterone and myocardiaI tension. Increased Ang Ⅱ may induce further myocardiaI structuraI damage and ventricuIar remodeIing through the ROS and caIcium imbaIance.
8.Normal Appearance of 3D Reconstruction of Multi-slice Computed Tomography in Adult skull
Xiaoxian JIANG ; Fajin Lü ; Hui XIE ; Lijuan ZHANG ; Zhiwei ZHANG
Chinese Journal of Medical Imaging 2010;(1):22-26
Purpose To describe the normal appearances of skull on 3D-reconstruction of Multi-slice CT in adult.Materials and Methods 130 patient data of Volume CT digital subtraction angiography (VCTDSA) with cephalocervical and cephalic vessel that were checked at our hospital from May to July 2009 were analyzed.All of them were subjected to 3D reconstruction of the skull by volume render (VR) and maximum intensity projection (MIP).The anatomy of skull,vascular grooves,pacchionian impressions,the types and closure status of cranial sutures were observed.Results 27 pacchionian impressions (20.77%,27/130) and 51 vascular grooves (39.23%,51/130) were detected.There were three types of the general shapes of cranial sutures:Ⅰconventional type(86.15%,112/130),Ⅱfontanelle ossification type(5.38%,7/130) and Ⅲcranial suture within a cranium (8.46%,11/130).Furthermore,Status of each suture closure were divided into five types:typeⅠcomplete closure(3.0%,16/531);typeⅡgomphosis(78.3%,416/531);typeⅢ sutural bone (7.0%,37/531);typeⅣincomplete closure(3.6%,19/531),the average width of non-closed suture was 1.41mm±0.70mm;typeⅤmixed type (8.1%,43/531).Conclusion 3D reconstruction of multi-slice computed tomography is proved to be a reliable technique capable of defining anatomy of skull.Better than MIP to displays three-dimensional structure VR,but to display cranial sutures,vascular grooves,pacchionian impressions MIP is more definite and hypersensitive.Status of each suture closure may be divided into five types,and the general shapes of cranial sutures may be divided into three types.
9.Study on Chemical Constituents in Rubus Pinfaensis
Xiaoxian WANG ; Hong ZHANG ; Lixia HU ; Geng ZHANG
China Pharmacist 2015;(6):913-916
Objective:To study the chemical constituents in the dry roots of Rubus pinfaensis. Methods:The compounds were sep-arated from the alcohol extract of the roots of Rubus pinfaensis by silica gel column chromatography, and identified by IR, 1 H-NMR and EI-MS methods. Results:Five compounds were isolated and identified as oleanolic acid (Ⅰ) , 3-keto, 16α-hydroxy, 24-noroleanolic acid (Ⅱ) , 3′-methoxy myricetin (Ⅲ) , 2′-deoxyuridine (Ⅳ) and p-hydroxy phenylacetic acid (Ⅴ) . Conclusion: Compound Ⅰ,Ⅱ,Ⅲ,Ⅳ and Ⅴ are isolated from Rubus pinfaensis for the first time.
10.Influence of the effect of general anaesthesia and restraint during dental treatment on dental anxiety and behavior in children
Hongmei ZHANG ; Bin XIA ; Jianhong WANG ; Xiaoxian CHEN ; Lihong GE
Journal of Peking University(Health Sciences) 2015;(1):134-139
Objective:To compare the level of dental anxiety and dental behavior between dental fear children with dental treatment under general anaesthesia ( GA) and those under restraint .Methods:The GA group included 31 dental fear children aged 4-6-year-old who received dental treatment under the GA.The restraint group included 31 dental fear children aged 4-6-year-old who received dental treat-ment under the restraint.Age, gender, parent’s education level, decayed-missing-filled tooth (dmft) and face version of the Modified Child Dental Anxiety Scale ( MCDASf ) score before treatment were matched between the two groups .The Chinese version of MCDAS f was used to evaluate the level of dental anxiety in each child before treatment , right after treatment and before examination at recall visit 2 -3 weeks after treatment .And the Chinese version of Venham Clinical Anxiety and Cooperative Behavior Scale was used to evaluate children ’ s dental behavior in each child before treatment and before examina-tion at recall visit 2-3 weeks after treatment .Results:The average scores of MCDAS f in GA group right after treatment and before recall were lower than that before treatment .The difference was statistically sig-nificant (P<0.05).Furthermore, the average score of MCDASf before recall was lower than those after treatment, and the difference was statistically significant (P<0.05).The average scores of MCDASf in restraint group right after treatment and 2-3 weeks after treatment were higher than those before treat-ment , but the difference was not statistically significant ( P>0 .05 ) .Children ’ s dental behavior was sig-nificantly improved at recall visit in both groups (P<0.01).Conclusion:Dental fear could be reduced by treatment under GA .The children ’ s dental behavior was improved after GA .Restraint did not result in the significant elevation of dental anxiety level , but dental behavior was improved after restraint during the short-term recall.