This paper introduces the basic principle,structure and technique characteristics of MM50 raceway electron cyclotron.Its clinical application to radiotherapy is discussed.

OBJECTIVE:To observe the efficacy and safety of atorvastatin in the treatment of hypertension with unstable angi-na. METHODS:80 patients with hypertension with unstable angina were randomly divided into control group and treatment group. All patients were given anti-platelet aggregation and other conventional treatment;based on it,control group was orally treated with Amlodipine besylate tablet 5 mg,once a day+Metoprolol tartrate controlled-release tablet 25 mg,twice a day+Isosorbide dini-trate injection 10 ml by intravenous infusion,twice a day;treatment group was additionally treated with Atorvastatin calcium tablet 20 mg,orally,qd. 3 months was a treatment course,and it lasted 6 courses. Clinical efficacy,and systolic blood pressure,diastol-ic blood pressure,angina frequency and duration,changes of TC,TG,LDL,HDL levels before and after treatment and adverse reac-tions in 2 groups were observed. RESULTS:Total effective rate in treatment group was significantly higher than control group,the difference was statistically significant(P<0.05). After treatment,systolic blood pressure and diastolic blood pressure in 2 groups were significantly lower or shorter than before,the difference was statistically significant(P<0.05),however,there was no signifi-cant difference between 2 groups(P>0.05);angina frequency and duration were significantly lower than before,and treatment group was lower than control group,TC,TG and LDL in treatment group were significantly lower than before and control group, HDL was higher than before and control group,the differences were statistically significant(P<0.05),there was no significant dif-ference between before and after treatment in control group(P>0.05). There was no significant difference in the adverse reactions between 2 groups(P>0.05). CONCLUSIONS:Based on the conventional treatment, atorvastatin can effectively reduce the long-term angina frequency and duration of patients with hypertension with unstable angina,improve the ischemia myocardial and reduce the lipid levels with good safety.

OBJECTIVE:To learn the way to improve innovation efficiency of technological development and achievement transformation stages in pharmaceutical industry in China. METHODS:The input and output data of pharmaceutical industry in 28 provinces(regions,cities)of China from 2001-2013 were estimated by using stochastic frontier analysis(SFA)so as to obtain in-novation efficiency of two stages. According to average efficiency of two stages,pharmaceutical industry of 28 provinces(regions, cities)were divided into 4 categories for further analysis. RESULTS & CONCLUSIONS:The innovation efficiency of pharmaceuti-cal industry in China was 0.626 2 at technology development stage and 0.567 8 at transformation stage,indicating they were not high either and the transformation efficiency was lagged behind the development efficiency. The coefficient of variation of innova-tion efficiency at transformation stage(0.274 2)was higher than development stage(0.194 5),indicating the difference degree of innovation efficiency at transformation stage was larger than at development stage. The areas with higher efficiency in both stages were in Eastern and economically developed regions,and the Western region with rich natural resources had higher efficiency at technological development stage,indicating region economic level or resource advantages created the conditions for the pharmaceuti-cal industry to enhance the innovation efficiency. It is suggested to further strengthen scientific achievement communication between pharmaceutical enterprises and pharmaceutical research institutions,and pay more attention to develop national medicine and tradi-tional Chinese medicine in Western region.

Objective To investigate the clinical features and risk factors of cytomegalovirus (CMV)infection in AIDS patients.Methods A total of 471 AIDS patients,including 173 with CMV infection and 298 without CMV infection were enrolled from Zhongnan Hospital of Wuhan University from June 2015 to August 2016.Multivariate Logistic regression was performed to analyze the risk factors for AIDS patients infected with CMV.Results Among 173 patients co-infected with CMV,103 (59.54%)were diagnosed as CMV viremia,70(40.46%)were CMV end-organ diseases (EOD),in which CMV pneumonia (n =33)and CMV retinitis (n =22)were the most frequent diseases.Univariate analysis showed that sexual transmission,low CD4 +T lymphocyte counts,first visit,tuberculosis,pneumococcal pneumonia (PCP), long hospital stay and septicemia were risk factors of cytomegalovirus infection among patients with AIDS (P <0.05).Multivariate Logistic regression analysis demonstrated that CD4 +T lymphocyte <50 cells/μL (OR =3.897,95%CI 2.354-6.453),concomitant tuberculosis(OR =4.619,95%CI 2.501 -8.529),PCP (OR =4.062,95%CI 2.345-7.038),sepsis (OR =2.553,95%CI 1 .098-5.936)were independent risk factors for CMV infection,while antiretroviral therapy (OR =0.559,95%CI 0.342-0.912)was a protective factor.Conclusions Hospitalized AIDS patients have a high incidence of CMV infection which has a tendency to induce multiple organ damage,and relevant risk factors should be avoid to accentuate disease as much as possible.

Objective To study the mechanism of Chinese Medicine in treating adenomyosis.Methods Thirty-seven patients in the Chinese Medicine treated group(17 cases of adenomyosis) and the control group(20 cases of adenomyosis,non-drug treated) underwent hysterectomy.Endometrium was looked as eutopic endometrium and adenomyosis as ectopic endometrium.Expression of MMP-9 and TIMP-1 in eutopic and ectopic endometrium were measured by immunohistochemical techniques.Meanwhile the levels of CA125 in serum were measured.Results The ectopic endometrium of the Chinese Medicine treated group expressed lower level of MMP-9,higher level of TIMP-1 and lower ratio of MMP-9/TIMP-1 than the ectopic endometrium of the control group(P

BACKGROUND: Ceramic crown porcelain fracture is wide in clinic. The method of repairing single crown porcelain fracture is simple and effective, but it is difficult for ceramic fixed bridge, especially individual teeth porcelain fracture on the long bridge. There is no report concerning prosthesis of partial crown with aperture of neighboring surface. OBJECTIVE: To lessen suffering and economic burden of the patient with cracking of porcelain on the fixed bridge, to decrease the chanciness and manufacture procedure of removing the porcelain fixed bridge, to discuss the feasibility of prosthesis of partial crown with aperture of neighouring surface.METHODS: By preparing tooth at damaged pontic or retainer of the porcelain fixed bridge in oral, shaping "core" retention form which analogy "keyway" form at both of retainers, and then make the porcelain partial crown with aperture of neighboring surface. RESULTS AND CONCLUSION: We followed up 27 patients that porcelain-fused-to-metal (PFM) with cracking of porcelain using partial crown with aperture of neighboring surface to repairing for 2-3 years. The prosthesis was strong; the edge of prosthesis was close together, without exposing metal or cracking of porcelain, gingival had no redness at the edge of crown and pontic. Patients feel good, chewing was normal. These suggested that the prosthesis of partial crown with aperture of neighboring surface is an effective method for restoring the fixed bridge with cracking of porcelain, with less risk, low cost and simple operation.

Objective To study the mechanism of Chinese Medicine in treating adenomyosis. Methods Thirty-seven patients in the Chinese Medicine treated group (17 cases of adenomyosis) and the control group (20 cases of adenomyosis, non-drug treated) underwent hysterectomy. Endometrium was looked as eutopic endometrium and adenomyosis as ectopic endometrium. Expression of MMP-9 and TIMP-1 in eutopic and ectopic endometrium were measured by immunohistochemical techniques. Meanwhile the levels of CA125 in serum were measured. Results The ectopic endometrium of the Chinese Medicine treated group expressed lower level of MMP-9, higher level of TIMP-1 and lower ratio of MMP-9/TIMP-1 than the ectopic endometrium of the control group (P<0.05). The levels of CA125 in serum were significantly decreased in Chinese Medicine group after treated as contrast with those in control group. Conclusion Chinese Medicine could reduce the level of CA125 and the ratio of MMP-9 and TIMP-1 to prevent the progression of adenomyosis.

Renal Tubular Cell Apoptosis refers to activation,proliferation,distension,cast formation and cellular apoptosis of the tubular epithelium when the renal tubule undergoes hypoxia,poisoning,inflammatory reaction,plasma protein or amylaceum.This text summarized the researches on the prevention and control of lenal tubular cell apoptosts in renal interstitial fibrosis in the recent years.

Objective To study the advantages of rhytidectomy of W-shaped incisions combined with multiple suspension in temporal hair line. Methods 40 patients were divided into two groups: 16 cases in group A were treated by rhytidectomy of W-shaped incisions combined with multiple suspcnsion in temporal hair line;24 cases in group B were treatcd by traditional rhytidectomy. Results The inci-sions in group A, with an excellent repair under scar formation, healed well and some hairs on the timpo-ral hair line grew. Fishtail lines were obviously reduced, with nasolabial fold lifting the masseter area skin on parotid. Compared with group B, the difference was statistically significant (P<0.05). Conclusions This approach is simple but convenient, safe and efficient. Therefore, it is valuable and applicable clinical-ly.

Objective To study the expression of acid secreted proteins that are rich in cysteine protein (SPARC protein)in gastric adenocarcinoma tissue and its relationship with the prognosis of patients with gastric cancer.Methods In order to detect SPARC protein expression levels in gastric adenocarcinoma ,104 primary gastric adenocarcinoma samples as well as 30 normal gastric tissues adjacent to carcinoma were studied by immu-nohistochemistry .Results The positive rate of SPARC protein in 30 cases of gastric mucosa adjacent to carcino-ma is 20%,and with weak expression or no expression;The positive rate in 104 cases of gastric cancer tissues was 76.1%,the difference was significant(P<0.01).The high expression rate of SPARC and lymph node metastasis in gastric adenocarcinoma were positively correlated (P<0.01).The SPARC expression rate of well and moderate differentiation of gastric adenocarcinoma were significantly lower than that of the low differentiation ( P<0 .05 ) . The average survival time of gastric cancer patients with high SPARC expression was 27.4 months.However,the average survival time of the patients with low SPARC expression was 40.9 months.The difference was significant (P<0.05).Conclusion SPARC protein is mainly high expressed in gastric cancer stromal tissue cells and fi-broblasts .The expression level of SPARC protein is significantly associated with lymph node metastasis and tumor differentiation degree .The high expression of SPARC patients survival time is short and the prognosis is poor . However ,SPARC protein is not an independent prognostic factor .