This paper introduces the basic principle,structure and technique characteristics of MM50 raceway electron cyclotron.Its clinical application to radiotherapy is discussed.

BACKGROUND: Ceramic crown porcelain fracture is wide in clinic. The method of repairing single crown porcelain fracture is simple and effective, but it is difficult for ceramic fixed bridge, especially individual teeth porcelain fracture on the long bridge. There is no report concerning prosthesis of partial crown with aperture of neighboring surface. OBJECTIVE: To lessen suffering and economic burden of the patient with cracking of porcelain on the fixed bridge, to decrease the chanciness and manufacture procedure of removing the porcelain fixed bridge, to discuss the feasibility of prosthesis of partial crown with aperture of neighouring surface.METHODS: By preparing tooth at damaged pontic or retainer of the porcelain fixed bridge in oral, shaping "core" retention form which analogy "keyway" form at both of retainers, and then make the porcelain partial crown with aperture of neighboring surface. RESULTS AND CONCLUSION: We followed up 27 patients that porcelain-fused-to-metal (PFM) with cracking of porcelain using partial crown with aperture of neighboring surface to repairing for 2-3 years. The prosthesis was strong; the edge of prosthesis was close together, without exposing metal or cracking of porcelain, gingival had no redness at the edge of crown and pontic. Patients feel good, chewing was normal. These suggested that the prosthesis of partial crown with aperture of neighboring surface is an effective method for restoring the fixed bridge with cracking of porcelain, with less risk, low cost and simple operation.

Objective To study the mechanism of Chinese Medicine in treating adenomyosis. Methods Thirty-seven patients in the Chinese Medicine treated group (17 cases of adenomyosis) and the control group (20 cases of adenomyosis, non-drug treated) underwent hysterectomy. Endometrium was looked as eutopic endometrium and adenomyosis as ectopic endometrium. Expression of MMP-9 and TIMP-1 in eutopic and ectopic endometrium were measured by immunohistochemical techniques. Meanwhile the levels of CA125 in serum were measured. Results The ectopic endometrium of the Chinese Medicine treated group expressed lower level of MMP-9, higher level of TIMP-1 and lower ratio of MMP-9/TIMP-1 than the ectopic endometrium of the control group (P<0.05). The levels of CA125 in serum were significantly decreased in Chinese Medicine group after treated as contrast with those in control group. Conclusion Chinese Medicine could reduce the level of CA125 and the ratio of MMP-9 and TIMP-1 to prevent the progression of adenomyosis.

Renal Tubular Cell Apoptosis refers to activation,proliferation,distension,cast formation and cellular apoptosis of the tubular epithelium when the renal tubule undergoes hypoxia,poisoning,inflammatory reaction,plasma protein or amylaceum.This text summarized the researches on the prevention and control of lenal tubular cell apoptosts in renal interstitial fibrosis in the recent years.

OBJECTIVE:To observe the efficacy and safety of atorvastatin in the treatment of hypertension with unstable angi-na. METHODS:80 patients with hypertension with unstable angina were randomly divided into control group and treatment group. All patients were given anti-platelet aggregation and other conventional treatment;based on it,control group was orally treated with Amlodipine besylate tablet 5 mg,once a day+Metoprolol tartrate controlled-release tablet 25 mg,twice a day+Isosorbide dini-trate injection 10 ml by intravenous infusion,twice a day;treatment group was additionally treated with Atorvastatin calcium tablet 20 mg,orally,qd. 3 months was a treatment course,and it lasted 6 courses. Clinical efficacy,and systolic blood pressure,diastol-ic blood pressure,angina frequency and duration,changes of TC,TG,LDL,HDL levels before and after treatment and adverse reac-tions in 2 groups were observed. RESULTS:Total effective rate in treatment group was significantly higher than control group,the difference was statistically significant(P<0.05). After treatment,systolic blood pressure and diastolic blood pressure in 2 groups were significantly lower or shorter than before,the difference was statistically significant(P<0.05),however,there was no signifi-cant difference between 2 groups(P>0.05);angina frequency and duration were significantly lower than before,and treatment group was lower than control group,TC,TG and LDL in treatment group were significantly lower than before and control group, HDL was higher than before and control group,the differences were statistically significant(P<0.05),there was no significant dif-ference between before and after treatment in control group(P>0.05). There was no significant difference in the adverse reactions between 2 groups(P>0.05). CONCLUSIONS:Based on the conventional treatment, atorvastatin can effectively reduce the long-term angina frequency and duration of patients with hypertension with unstable angina,improve the ischemia myocardial and reduce the lipid levels with good safety.

OBJECTIVE:To learn the way to improve innovation efficiency of technological development and achievement transformation stages in pharmaceutical industry in China. METHODS:The input and output data of pharmaceutical industry in 28 provinces(regions,cities)of China from 2001-2013 were estimated by using stochastic frontier analysis(SFA)so as to obtain in-novation efficiency of two stages. According to average efficiency of two stages,pharmaceutical industry of 28 provinces(regions, cities)were divided into 4 categories for further analysis. RESULTS & CONCLUSIONS:The innovation efficiency of pharmaceuti-cal industry in China was 0.626 2 at technology development stage and 0.567 8 at transformation stage,indicating they were not high either and the transformation efficiency was lagged behind the development efficiency. The coefficient of variation of innova-tion efficiency at transformation stage(0.274 2)was higher than development stage(0.194 5),indicating the difference degree of innovation efficiency at transformation stage was larger than at development stage. The areas with higher efficiency in both stages were in Eastern and economically developed regions,and the Western region with rich natural resources had higher efficiency at technological development stage,indicating region economic level or resource advantages created the conditions for the pharmaceuti-cal industry to enhance the innovation efficiency. It is suggested to further strengthen scientific achievement communication between pharmaceutical enterprises and pharmaceutical research institutions,and pay more attention to develop national medicine and tradi-tional Chinese medicine in Western region.

Objective To study the mechanism of Chinese Medicine in treating adenomyosis.Methods Thirty-seven patients in the Chinese Medicine treated group(17 cases of adenomyosis) and the control group(20 cases of adenomyosis,non-drug treated) underwent hysterectomy.Endometrium was looked as eutopic endometrium and adenomyosis as ectopic endometrium.Expression of MMP-9 and TIMP-1 in eutopic and ectopic endometrium were measured by immunohistochemical techniques.Meanwhile the levels of CA125 in serum were measured.Results The ectopic endometrium of the Chinese Medicine treated group expressed lower level of MMP-9,higher level of TIMP-1 and lower ratio of MMP-9/TIMP-1 than the ectopic endometrium of the control group(P

Objective To investigate the clinical features and risk factors of cytomegalovirus (CMV)infection in AIDS patients.Methods A total of 471 AIDS patients,including 173 with CMV infection and 298 without CMV infection were enrolled from Zhongnan Hospital of Wuhan University from June 2015 to August 2016.Multivariate Logistic regression was performed to analyze the risk factors for AIDS patients infected with CMV.Results Among 173 patients co-infected with CMV,103 (59.54%)were diagnosed as CMV viremia,70(40.46%)were CMV end-organ diseases (EOD),in which CMV pneumonia (n =33)and CMV retinitis (n =22)were the most frequent diseases.Univariate analysis showed that sexual transmission,low CD4 +T lymphocyte counts,first visit,tuberculosis,pneumococcal pneumonia (PCP), long hospital stay and septicemia were risk factors of cytomegalovirus infection among patients with AIDS (P <0.05).Multivariate Logistic regression analysis demonstrated that CD4 +T lymphocyte <50 cells/μL (OR =3.897,95%CI 2.354-6.453),concomitant tuberculosis(OR =4.619,95%CI 2.501 -8.529),PCP (OR =4.062,95%CI 2.345-7.038),sepsis (OR =2.553,95%CI 1 .098-5.936)were independent risk factors for CMV infection,while antiretroviral therapy (OR =0.559,95%CI 0.342-0.912)was a protective factor.Conclusions Hospitalized AIDS patients have a high incidence of CMV infection which has a tendency to induce multiple organ damage,and relevant risk factors should be avoid to accentuate disease as much as possible.

Objective To investigate the incidence,etiology,diagnosis,treatment and outcome of uterus rupture.Methods From January 1999 to May 2013,clinical data of 67 cases with uterine rupture in Woman's Hospital,School of Medicine,Zhejiang University were studied retrospectively.Results A total of 67 cases of uterine rupture with 21 +2--39 +2 gestational weeks out of 128 599 deliveries were recorded giving an incidence of uterine rupture was 0.052 1 ％ (67/128 599).Cesarean scar rupture were found in 59 cases (88％,59/67) and noncesarean scar rupture were found in 8 cases (12％,8/67).The causes of uterine rupture include 60 cases of scar uterus (59 cesarean scar cases and 1 myomyectomy scar case),2 cases of assisted delivery operation trauma,2 cases of malformed uterus,3 cases of unknown causes (all with artificial abortion history).Non obstructive dystocia and improper oxytocin use were found to be related with uterine rupture.Fifty-two cases of cesarean scar spontaneous incomplete rupture were found and repaired during repeated cesarean delivery without maternal and fetal complications.The remaining 15 cases need emergency rescue operation for fetal distress or dead fetus,severe acute abdomen,prepartum or postpartum vaginal bleeding even maternal hypovolemia; 6/15 uterine rupture cases were diagnosed with the history,clinical symptoms and signs,3/15 cases with ultrasonic found dead fetus in the peritoneal cavity before exploratory laparotomy and 6 cases were diagnosed just during laparotomy.Hysterectomy was done in 10/15 cases and uterine repair in 5/15 cases; there was no maternal death and 12 perinatal fetal death (5 cases of mid-late pregnancy termination for deformed fetus) of the 15 uterine rupture cases.One case with hysterectomy was complicated with stress pancreatitis and dysfunction of liver and kidney and discharged 20 days after operation,the remaining 14 cases were discharged 5-7 days postpartum.One case with repaired malformed uterus got pregnancy 4 years later and delivered a 2 000 g healthy baby by cesarean section at gestational age of 33 +4 weeks.Conclusion Uterine scar caused by caesarean section or other operations became the leading cause of uterine rupture,assisted delivery operations,history of intrauterine manipulation and uterine malformations were the predisposing risk factors of uterine rupture.

Objective To probe into the relationship between social support, coping styles and resiliency of nurses in surgery department. Methods A total of 192 surgical nurses were selected from a general tertiary hospital in Fuzhou on random cluster sampling basis. The following measures were used to collect data:the Chinese version of Mental Resilience Scale, the Simple Coping Style Questionnaire and the Social Support Rating Scale. Results The resilience score of surgical nurses was (58.41 ± 12.86) points. Also, resilience had positive and significant correlation with positive coping styles, social support, objective support , subjective support and support utilization degree (more specifically r = 0.629, P <0.01 and r = 0.334, P < 0.01, r = 0.242, P < 0.01 and r = 0.312, P < 0.01 and r = 0.156, P < 0.05). Conclusions The overall level of resiliency in surgical nurses was undesirable, however effective problem-based coping skills and adequate social support may help the group improve resilience and to qualify for better nursing services.