Objective To investigate the mechanisms of early sensorineural hearing loss of diabetic rats. Methods The diabetic model for rats was established. Every rat was checked with ABR and DPOAE before and af-ter treatment . After 14 days , the blood glucose, blood fat, SOD, GSH-Px and MDA were measured. Results For the model group, the rats" blood glucose and fat increased while the GSH-Px was reduced more than the con-trol group. The response amplitudes of DPOAE decreased at 4 000 Hz and 8 000 Hz(P<0. 05). Conclusion The damage to the hair cells caused by the affected metabolism is considered as the culprit of the sensorineural hearing loss and the changes of DPOAE took place earlier than that of ABR, thus becoming useful in detecting early hearing loss of the diabetic patients.

Objective To evaluate the efficacy and safety of the transobturator tension-free vaginal tape (TVT-O) surgery, a minimally invasive surgery for treating patients with the stress urinary incontinence (SUI). Methods 28 cases with female stress uri-nary incontinence treated by TVT-O procedure from April 2006 to June 2008 were retrospectively analyzed. The follow-up time is from 4 to 24 months. Results The mean operation time was 23 min (rang 10～30 min) and the mean intraoperative bleeding was 24 ml (range 15～40 ml). An indwelling catheter had been used for 3 d because of urinary retention in 3 cases. 24 patients(85.7%)reached complete control after the surgery,effective control in 4 patients(14.35%). Conclusions TVT-O surgery is an effective, safe, minimally invasive management to treat the stress urinary incontinence.