Hand ; Humans ; Reference Standards ; Vibration

Objective To study the value of~1H-magnetic resonance spectroscopy(~1H-MRS) and diffusion weighted imaging(DWI) in evaluating the changes of pathological structures of hippocampal sclerosis.Methods Twelve normal controls and twelve cases with temporal lobe epilepsy were examined by conventional MRI,~1H-MRS and DWI.The NAA/(Cr+Cho) ratios and ADC values in the hippocampus were measured and compared between patients and normal controls.Results The NAA/(Cr+Cho) ratios of hippocampus in patients with hippocampal sclerosis were significant decrease in comparison with controls and the contralateral side,and the ADC values were also significant increase.There was correlation between the NAA/(Cr+Cho) ratios and ADC values in the disordered hippocampus(r=-0.79,P=0.002).Conclusion There is a significant correlation between the NAA/(Cr+Cho) ratios and ADC values in the hippocampal sclerosis.~1H-MRS and DWI capture partially complementary aspects of hippocampal pathology noninvasively in vivo.

Objective To investigate the therapeutic effect of licorice zinc on melasma.Methods Thirty-six BALB/c mice were equally divided into blank group,model group,licorzinc low-dose group,licorzine medium-dose group,licorzinc high-dose group and tranexamic acid group.Melasma was induced by 100 mJ/cm2 UVB irradiation combined with 15 mg/kg progesterone injection.Mice were treated with tranexamic acid(0.065 g/kg)and low(0.65 g/kg),medium(1.3 g/kg),or high(2.6 g/kg)doses of zinc licorice for 14 days.Skin was taken for HE and Masson-Fontana staining and measurement of SOD,MDA,GSP-Px,TNF-α,IL-1β,IL-6,plasma protein Nrf-2,nuclear protein Nrf-2 and HO-1 expression levels.Results Compared with model group,high-dose licorice zinc group showed decreased melanocyte formation,collagen cell necrosis,and inflammatory infiltration(P＜0.01);decreased MDA,IL-6,IL-1β,TNF-α and plasma protein Nrf-2 expression(P＜0.01);and increased GSP-Px,SOD and nuclear protein Nrf-2 and HO-1 expression(P＜0.01).Conclusions Zinc licorice activates the Nrf-2/HO-1 pathway to initiate high expression of HO-1,SOD and GSP-Px and fight oxidative stress,thereby reducing melanogenesis.

Objective:To investigate the clinical efficacy of 30% supramolecular salicylic acid combined with 420 nm intense pulsed light in the treatment of facial seborrheic dermatitis.Methods:A total of 60 patients with facial seborrheic dermatitis were selected from January 2018 to December 2021, that were randomly divided into 30% salicylic acid group, 420 nm intense pulsed light group and combined group. Each group had 20 patients. They were treated once every two weeks in four consecutive rounds. The adverse reactions of patients were followed up each time, and the data were analysed and evaluated four weeks after the last treatment.Results:After treatment, the total score of clinical symptoms and signs in the combined group were significantly lower than those in the other groups (3.95±1.731 vs. 7.15±2.059, 7.50±1.732, F=22.434, P<0.05). The effective rate in combined group was 95%, which was significantly higher than 65% of salicylic acid group and 60% of intense pulsed light group (χ 2=7.33, P<0.05), and no obvious adverse reactions were found in the three groups. Conclusions:30% supramolecular salicylic acid combined with 420 nm intense pulsed light is safe and effective in the treatment of facial seborrheic dermatitis.

Objective: To evaluate the clinical outcomes of a series of patients who have undergone reconstruction of craniofacial defects after resection of intracranial tumors or craniofacial trauma with free composite anterolateral thigh flaps. Methods: Retrospective analyses the clinical cases from September 2007 to September 2016. Data included flap survival rate, complication, satisfaction survey was reviewed to evaluate the efficacy and safety of this surgical strategy. Results: Totally 10 free anterolateral thigh flaps including 3 cases of fasciocutaneous flaps, 2 case of adipofascial flaps, 4 cases of myocutaneous flaps, 1 case of chimeric flap, were adopted to reconstruct craniofacial defects. Follow-up ranged from 3 to 17 months (average, 12 months). All flaps were transferred successfully. There were no cranial spinal fluid(CSF) leaks, intracranial infections or donor site complications. All patients were satisfied. Conclusions Because of its abundance of tissue, matched vessels to recipient site, versatility of muscular flaps to fill irregularly intracranial defects, reliable blood supply, feasibility of simultaneous fascia lata harvesting, free composite anterolateral thigh flap is the reconstructive method of choice for craniofacial defects reconstruction after resection of intracranial tumors or craniofacial trauma. The use of ALT flap was reliable in the decrease of CSF leak and infection rate and dependable according to long time follow-up.

Objective To analyze the literatures about artificial intelligence in cancer research in Web of Science (WOS) core collection database in 2010-2019 and summarize research hot spots and development trends. Methods Through bibliometrics methods and CiteSpace information visualization software, we applied the visual analysis of relevant literature on artificial intelligence in the field of cancer research retrieved from the Web of Science core collection database from 2010 to 2019. Results The number of published articles about artificial intelligence in the field of cancer research had been increasing year by year. The United States ranked first in the number of published articles in this field, the number of citations and cooperation capabilities. Although the number of published articles in China ranked the second, the number of citations was low. The hot spots of artificial intelligence in cancer research were mainly breast cancer and lung cancer. Machine learning, neural network and other methods were used to build models, which were used in basic cancer research, clinical diagnosis, treatment and prognosis prediction. The research frontiers were the methodological research of artificial intelligence, the research on the occurrence and classification of cancer and the research of protein in this field. Conclusion It will effectively promote the development of artificial intelligence in cancer research in China by learning the hot spots and cutting-edge technologies of international research, focusing on international cooperation and cooperation among national institutions and strengthening cross-disciplinary research.

Objective To investigate the features of hand-transmitted vibration of common vibration tools in the workplace for automobile casting and assembly.Methods From September to October,2014,measurement and spectral analysis were performed for 16 typical hand tools (including percussion drill,pneumatic wrench,grinding machine,internal grinder,and arc welding machine) in 6 workplaces for automobile casting and assembly according to ISO 5349-1-2001 Mechanical vibration-Measurement and evaluation of human exposure to hand-transmitted vibration-part 1:General requirements and ISO 5349-2-2001 Mechanical vibration-Measurement and evaluation of human exposure to hand-transmitted vibration-Part 2:Practical guidance for measurement in the workplace.Results The vibration acceleration waveforms of shearing machine,arc welding machine,and pneumatic wrench were mainly impact wave and random wave,while those of internal grinder,angle grinder,percussion drill,and grinding machine were mainly long-and short-period waves.The daily exposure duration to vibration of electric wrench,pneumatic wrench,shearing machine,percussion drill,and internal grinder was about 150 minutes,while that of plasma cutting machine,angle grinder,grinding machine,bench grinder,and arc welding machine was about 400 minutes.The range of vibration total value (ahw) was as follows:pneumatic wrench 0.30～11.04 m/s2,grinding wheel 1.61 ～8.97 m/s2,internal grinder 1.46～8.70 m/s2,percussion drill 11.10～14.50 m/s2,and arc welding machine 0.21～2.18 m/s2.The workers engaged in cleaning had the longest daily exposure duration to vibration,and the effective value of 8-hour energy-equivalent frequency-weighted acceleration for them[A (8)] was 8.03 m/s2,while this value for workers engaged in assembly was 4.78 m/s2.The frequency spectrogram with an 1/3-time frequency interval showed that grinding machine,angle grinder,and percussion drill had a high vibration acceleration,and the vibration limit curve was recommended for those with a frequency higher than 400 min/d.Conclusion The workers who are engaged in cleaning,grinding,and a few positions of assembly and use grinding machine,angle grinder,internal grinder,and percussion drill are exposed to vibrations with a high vibration acceleration and at a high position of the frequency spectrum.The hand-transmitted vibration in the positions of cutting,polishing,and cleaning in automobile casting has great harm,and the harm caused by pneumatic wrench in automobile assembly should be taken seriously.

Objective To investigate the influence of two positions for measuring instrument adapter on the measurement of hand-transmitted vibration in grinding machine using the intraclass correlation coefficient (ICC) of reliability assessment index,and to provide a basis for studies on the measurement standard for handtransmitted vibration.Methods With reference to the measurement standard for hand-transmitted vibration ISO 5349 Mechanical vibration-Measurement and evaluation of human exposure to hand-transmitted vibration-Part 1:General requirements and Mechanical vibration-Measurement and evaluation of human exposure to handtransmitted vibration-Part 2:Practical guidance for measurement at the workplace,the domestic AWA5936 hand-transmitted vibration measuring instrument and SVAN-106 hand-transmitted vibration measuring instrument from Poland were used to measure hand-transmitted vibration in 3 workers for grinding machine in a foundry for 5 days continuously from September to October,2014,and Y-axis data were recorded and compared.Results In worker A,the "T"-shaped adapter had a significantly higher mean Y-axis accelerated speed effective value than the "O"-shaped adapter [4.34 m/s2 (95％CI 4.05-4.63) vs 2.32 m/s2 (95％CI 2.27～2.38),t=13.781,P＜0.01]-In workers B and C,AWA5936 "U"-shaped adapter (placed at the position of the handle of grinding machine) had lower degrees of data variation of 12.55％ and 15.77％,respectively,suggesting good data stability.The measurement results showed significant differences across different positions of adapter(P＜0.01) and between all adapters except "O"-shaped and line-shaped adapters (all P＜0.01),while the measurement results showed no significant differences between the"O"-shaped and line-shaped adapters (P＞0.01).The comparison of the measurement results of AWA5936 vibration measuring instrument with an "U"-shaped adapter and SVAN-106 vibration measuring instrument with an "S"-shaped adapter showed an ICC of ＞0.80 (ICC=0.82),while the comparison of the measurement results of AWA5936 vibration measuring instrument with an "O"-shaped adapter and SVAN-106 vibration measuring instrument showed an ICC of ＜0.40.Conclusion SVAN-106 vibration measuring instrument with an "S"-shaped adapter placed at the palm and AWA5936 vibration measuring instrument with an"U"-shaped adapter placed at the handle of grinding machine can give comparable measurement results with good reliability.

Objective To investigate the features of hand-transmitted vibration of common vibration tools in the workplace for automobile casting and assembly.Methods From September to October,2014,measurement and spectral analysis were performed for 16 typical hand tools (including percussion drill,pneumatic wrench,grinding machine,internal grinder,and arc welding machine) in 6 workplaces for automobile casting and assembly according to ISO 5349-1-2001 Mechanical vibration-Measurement and evaluation of human exposure to hand-transmitted vibration-part 1:General requirements and ISO 5349-2-2001 Mechanical vibration-Measurement and evaluation of human exposure to hand-transmitted vibration-Part 2:Practical guidance for measurement in the workplace.Results The vibration acceleration waveforms of shearing machine,arc welding machine,and pneumatic wrench were mainly impact wave and random wave,while those of internal grinder,angle grinder,percussion drill,and grinding machine were mainly long-and short-period waves.The daily exposure duration to vibration of electric wrench,pneumatic wrench,shearing machine,percussion drill,and internal grinder was about 150 minutes,while that of plasma cutting machine,angle grinder,grinding machine,bench grinder,and arc welding machine was about 400 minutes.The range of vibration total value (ahw) was as follows:pneumatic wrench 0.30～11.04 m/s2,grinding wheel 1.61 ～8.97 m/s2,internal grinder 1.46～8.70 m/s2,percussion drill 11.10～14.50 m/s2,and arc welding machine 0.21～2.18 m/s2.The workers engaged in cleaning had the longest daily exposure duration to vibration,and the effective value of 8-hour energy-equivalent frequency-weighted acceleration for them[A (8)] was 8.03 m/s2,while this value for workers engaged in assembly was 4.78 m/s2.The frequency spectrogram with an 1/3-time frequency interval showed that grinding machine,angle grinder,and percussion drill had a high vibration acceleration,and the vibration limit curve was recommended for those with a frequency higher than 400 min/d.Conclusion The workers who are engaged in cleaning,grinding,and a few positions of assembly and use grinding machine,angle grinder,internal grinder,and percussion drill are exposed to vibrations with a high vibration acceleration and at a high position of the frequency spectrum.The hand-transmitted vibration in the positions of cutting,polishing,and cleaning in automobile casting has great harm,and the harm caused by pneumatic wrench in automobile assembly should be taken seriously.

Objective To investigate the influence of two positions for measuring instrument adapter on the measurement of hand-transmitted vibration in grinding machine using the intraclass correlation coefficient (ICC) of reliability assessment index,and to provide a basis for studies on the measurement standard for handtransmitted vibration.Methods With reference to the measurement standard for hand-transmitted vibration ISO 5349 Mechanical vibration-Measurement and evaluation of human exposure to hand-transmitted vibration-Part 1:General requirements and Mechanical vibration-Measurement and evaluation of human exposure to handtransmitted vibration-Part 2:Practical guidance for measurement at the workplace,the domestic AWA5936 hand-transmitted vibration measuring instrument and SVAN-106 hand-transmitted vibration measuring instrument from Poland were used to measure hand-transmitted vibration in 3 workers for grinding machine in a foundry for 5 days continuously from September to October,2014,and Y-axis data were recorded and compared.Results In worker A,the "T"-shaped adapter had a significantly higher mean Y-axis accelerated speed effective value than the "O"-shaped adapter [4.34 m/s2 (95％CI 4.05-4.63) vs 2.32 m/s2 (95％CI 2.27～2.38),t=13.781,P＜0.01]-In workers B and C,AWA5936 "U"-shaped adapter (placed at the position of the handle of grinding machine) had lower degrees of data variation of 12.55％ and 15.77％,respectively,suggesting good data stability.The measurement results showed significant differences across different positions of adapter(P＜0.01) and between all adapters except "O"-shaped and line-shaped adapters (all P＜0.01),while the measurement results showed no significant differences between the"O"-shaped and line-shaped adapters (P＞0.01).The comparison of the measurement results of AWA5936 vibration measuring instrument with an "U"-shaped adapter and SVAN-106 vibration measuring instrument with an "S"-shaped adapter showed an ICC of ＞0.80 (ICC=0.82),while the comparison of the measurement results of AWA5936 vibration measuring instrument with an "O"-shaped adapter and SVAN-106 vibration measuring instrument showed an ICC of ＜0.40.Conclusion SVAN-106 vibration measuring instrument with an "S"-shaped adapter placed at the palm and AWA5936 vibration measuring instrument with an"U"-shaped adapter placed at the handle of grinding machine can give comparable measurement results with good reliability.