Objective To investigate the effects of monocyte chemoattractant protein-1 (MCP-1) on the migration of neural stem cells in vivo. Methods The brain injured rat model was established with cortical micro-injection of lipopolysaccharide in Sprague-Dawley rats. The tissue of brain was immunohistochemistrically stained to detect the expression of MCP-1 and nestin 3 d, 5 d, and 7 d after modeling. Results The expression of MCP-1 increased, and reached a peak 5 d after modeling. The nestin-positive cells was found in the lipopolysaccharide injected area 7 d after modeling. Conclusion MCP-1 may induce the endogenous neural stem cells migrate to lipopolysaccharide injection area in vivo.

Objective To explore the clinical value of multi-slice spiral CT (MSCT) and serum inflammatory markers in diagnosis of acute appendicitis.Methods A total of 78 patients with acute appendicitis who were admitted in our hospital from November 2015 to November 2016 were included in the study.Different CT grading,postoperative pathological types (simple appendicitis,purulent appendicitis,gangrenous appendicitis),WBC count of different pathogenic bacteria (E.coli,P.aeruginosa,and K.pneumoniae),NEUT％,and CRP level were detected.Results With the increasing of CT grading,WBC count,NEUT％,and CRP level were gradually elevated (P ＜ 0.05).WBC count,NEUT％,and CRP level in patients with simple appendicitis were significantly less than those with purulent appendicitis,and gangrenous appendicitis.And above indicators of patients with purulent appendicitis were significantly less than those with gangrenous appendicitis,and the pathological type showed a significant difference (P ＜ 0.05).The WBC count,NEUT％,and CRP level among patients with different pathogenic bacteria showed no significant difference (P ＞ 0.05).Conclusion Dynamic monitoring of WBC count,NEUT％,and CRP level and MSCT examination can contribute to more accurate diagnosis of acute appendicitis and the estimation of condition.

Objective To explore the clinical value of multi-slice spiral CT (MSCT) and serum inflammatory markers in diagnosis of acute appendicitis.Methods A total of 78 patients with acute appendicitis who were admitted in our hospital from November 2015 to November 2016 were included in the study.Different CT grading,postoperative pathological types (simple appendicitis,purulent appendicitis,gangrenous appendicitis),WBC count of different pathogenic bacteria (E.coli,P.aeruginosa,and K.pneumoniae),NEUT％,and CRP level were detected.Results With the increasing of CT grading,WBC count,NEUT％,and CRP level were gradually elevated (P ＜ 0.05).WBC count,NEUT％,and CRP level in patients with simple appendicitis were significantly less than those with purulent appendicitis,and gangrenous appendicitis.And above indicators of patients with purulent appendicitis were significantly less than those with gangrenous appendicitis,and the pathological type showed a significant difference (P ＜ 0.05).The WBC count,NEUT％,and CRP level among patients with different pathogenic bacteria showed no significant difference (P ＞ 0.05).Conclusion Dynamic monitoring of WBC count,NEUT％,and CRP level and MSCT examination can contribute to more accurate diagnosis of acute appendicitis and the estimation of condition.