1.Radiologic Findings and Clinical Significance of the Herniation Pits of the Femoral Neck
Bo HAN ; Guangfu YANG ; Xiaojun YANG ; Xiaoqun YAO ; Hui LIU ; Bin HE ; Xincheng YAN ; Jinzhu LI ; Xiaojun REN ; Wenkui ZHANG ; Xianmin FU
Journal of Practical Radiology 2010;26(4):541-543
Objective To study the incidence and clinical significance of the herniation pits of the femoral neck.Methods 600 cases(299 men,301 women,18~82 years)were collected.The incidence,radiologic finding and clinical significance of the herniation pit of the femoral neck were analysed.Results Of 1200 hip joints in 600 cases,there was 58 cases(64 sides)(5.3%)with herniation pits of the femoral neck,including 39 men(68.7%)and 19 women(31.3%),the lesions localized in the left joint in 25 eases(39.1%),in the right joint in 27 cases(42.2%)and in bilateral joints in 6 cases(18.7%).There were a obvious significant differences on both sexes,and no significant differences on age groups.On X-ray film,the lesions appeared as a round radiolucency with thin clear sclerotic rim.Conclusion The incidence of the herniation pit of the femoral neck is 5.3%,which has a typical X-ray feature,and may indicate the femoroacetabular impingement.
2.Analysis of the Development Status of Clinical Pharmacogenomics Based on External Quality Assessment from 2014 to 2019 in China
Youyou CHEN ; Huayun LI ; Xiaoqun REN ; Yan DAI
China Pharmacy 2020;31(16):1938-1943
OBJECTIVE:To provide reference for promoting individualized medication in clinic. METHODS :Information on external quality assessment (EQA)projects and approved kits for the guidance of chemical drug use were collected from the websites of National Center for Clinical Laboratories (NCCL) and National Medical Products Administration (NMPA) as of December 31,2019. The number of laboratories participating in each evaluation project was count. Taking EQA projects of clopidogrel and warfarin drug metabolism gene polymorphism detection as examples ,who was with the highest participation rate , the methods and reagent kits of each laboratory were analyzed so as to analyze the current status of the clinical pharmacogenomics (PGx)in China. RESULTS :The number of PGx genetic test EQA projects conducted by NCCL increased from 3(2014)to 9 (2019). The total number of participating laboratories was 926 in 2018,and 1 249 in 2019. The number of laboratories of warfarin and clopidogrel drug metabolism gene polymorphism detection increased from 57 to 300.5 for warfarin and from 124 to 374.5 for clopidogrel. The more widely used methods were fluorescent PCR and PCR-chip hybridization. The number of reagent kits currently approved by NMPA was 7 for warfarin and 15 for clopidogrel ,respectively. But some of the laboratories participating in EQA used self-prepared reagents yet. CONCLUSIONS :The clinical PGx is in its infancy ,and the awareness of laboratories about EQA is improving;the main method was fluorescence PCR ,but the use of self-made reagents in laboratories is still common ,regulations concerning the approval ,use and supervision still need to be further improved.
3.FTO stabilizes MIS12 and counteracts senescence.
Sheng ZHANG ; Zeming WU ; Yue SHI ; Si WANG ; Jie REN ; Zihui YU ; Daoyuan HUANG ; Kaowen YAN ; Yifang HE ; Xiaoqian LIU ; Qianzhao JI ; Beibei LIU ; Zunpeng LIU ; Jing QU ; Guang-Hui LIU ; Weimin CI ; Xiaoqun WANG ; Weiqi ZHANG
Protein & Cell 2022;13(12):954-960